The Role of MicroRNAs in Progressive Supranuclear Palsy—A Systematic Review DOI Open Access

Aleksandra Ćwiklińska,

Grzegorz Procyk, Dariusz Koziorowski

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8243 - 8243

Published: July 28, 2024

Progressive supranuclear palsy (PSP) is a rare, neurodegenerative movement disorder. Together with multiple system atrophy (MSA), Dementia Lewy bodies (DLB), and corticobasal degeneration (CBD), PSP forms group of atypical parkinsonisms. The latest diagnostic criteria, published in 2017 by the Movement Disorders Society, classify diagnosis into defined, probable, possible categories based on clinical examination. However, no single test specific sensitive for this disease. Microribonucleic acids (miRNAs) are promising molecules, particularly case diseases that lack appropriate treatment tools, which supports exploring their role PSP. We aimed to systematically review current knowledge about miRNAs This study was registered Open Science Framework Registry, protocol available online. Primary original studies, both preclinical, written English assessing were included. Systematic reviews, meta-analyses, reports, letters editors, commentaries, conference abstracts, guidelines/statements, expert opinions, preprints, book chapters excluded. following five databases searched: Embase, Medline Ultimate, PubMed, Scopus, Web Science. Each database last searched 18 June 2024. Eventually, nine studies relevant discussed area risk bias not assessed. selected research suggests may be considered biomarkers exact involvement pathogenesis still determined. Several microRNAs found dysregulated patients applies brain tissue fluids like cerebrospinal fluid CSF or blood. could potentially helpful differentiating among patients, PD healthy individuals. Although some correlations alterations have already been found, field requires much more research. MicroRNAs exciting small investigation many diseases, including PSP, lead significant discoveries.

Language: Английский

Fluid-based biomarkers for neurodegenerative diseases DOI Creative Commons
Yongliang Cao, Yifei Xu, Meiqun Cao

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102739 - 102739

Published: March 1, 2025

Language: Английский

Citations

0
FAIR assessment of MINERVA as an opportunity to foster open science and scientific crowdsourcing in systems biomedicine DOI Creative Commons
Irina Balaur, Danielle Welter, Adrien Rougny

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 29, 2024

The Disease Maps Project (https://disease-maps.org) focuses on the development of disease-specific comprehensive structured knowledge repositories supporting translational medicine research. These disease maps require continuous interdisciplinary collaboration, and they should be reusable interoperable. Adhering to Findable, Accessible, Interoperable Reusable (FAIR) principles enhances utility such digital assets. We used RDA FAIR Data Maturity Model assessed FAIRness Molecular Interaction NEtwoRk VisuAlization (MINERVA) Platform. MINERVA is a standalone webserver that allows users manage, explore analyze their related data manually or programmatically. exemplify assessment Parkinson's Map (PD map) COVID-19 Map, which are large-scale projects under umbrella Project, aiming investigate molecular mechanisms SARS-CoV-2 infection, respectively. discuss features supported by Platform we outline steps further improve better connect this resource other ongoing scientific initiatives in computational systems biomedicine.

Language: Английский

Citations

2
Biological Function Analysis of MicroRNAs and Proteins in the Cerebrospinal Fluid of Patients with Parkinson’s Disease DOI Open Access
Ji Su Hwang, Seok Gi Kim,

Nimisha Pradeep George

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13260 - 13260

Published: Dec. 10, 2024

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by alpha-synuclein aggregation into Lewy bodies in the neurons. Cerebrospinal fluid (CSF) considered most suited source for investigating PD pathogenesis and identifying biomarkers. While microRNA (miRNA) profiling can aid investigation of post-transcriptional regulation diseases, information on miRNAs CSF patients with remains limited. This review combines miRNA analysis proteomic to explore collective impact mechanisms PD. We constructed separate networks altered proteomes using bioinformatics method. Altered were poorly linked biological functions owing limited information; however, changes protein expression strongly associated functions. Subsequently, integrated further analysis. In silico prediction from network revealed relationships between proteins, highlighting increased reactive oxygen species generation, neuronal loss, neurodegeneration suppressed ATP synthesis, mitochondrial function, neurotransmitter release The approach suggests potential as biomarkers critical underlying combined strategy could enhance our understanding complex biochemical support development diagnostic therapeutic strategies precision medicine.

Language: Английский

Citations

1
The Role of MicroRNAs in Progressive Supranuclear Palsy—A Systematic Review DOI Open Access

Aleksandra Ćwiklińska,

Grzegorz Procyk, Dariusz Koziorowski

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(15), P. 8243 - 8243

Published: July 28, 2024

Progressive supranuclear palsy (PSP) is a rare, neurodegenerative movement disorder. Together with multiple system atrophy (MSA), Dementia Lewy bodies (DLB), and corticobasal degeneration (CBD), PSP forms group of atypical parkinsonisms. The latest diagnostic criteria, published in 2017 by the Movement Disorders Society, classify diagnosis into defined, probable, possible categories based on clinical examination. However, no single test specific sensitive for this disease. Microribonucleic acids (miRNAs) are promising molecules, particularly case diseases that lack appropriate treatment tools, which supports exploring their role PSP. We aimed to systematically review current knowledge about miRNAs This study was registered Open Science Framework Registry, protocol available online. Primary original studies, both preclinical, written English assessing were included. Systematic reviews, meta-analyses, reports, letters editors, commentaries, conference abstracts, guidelines/statements, expert opinions, preprints, book chapters excluded. following five databases searched: Embase, Medline Ultimate, PubMed, Scopus, Web Science. Each database last searched 18 June 2024. Eventually, nine studies relevant discussed area risk bias not assessed. selected research suggests may be considered biomarkers exact involvement pathogenesis still determined. Several microRNAs found dysregulated patients applies brain tissue fluids like cerebrospinal fluid CSF or blood. could potentially helpful differentiating among patients, PD healthy individuals. Although some correlations alterations have already been found, field requires much more research. MicroRNAs exciting small investigation many diseases, including PSP, lead significant discoveries.

Language: Английский

Citations

0