Psilocybin for disorders of consciousness: a case-report study
Clinical Neurophysiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 1, 2025
Language: Английский
H‐current modulation of cortical Up and Down states
The Journal of Physiology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 28, 2025
Abstract
Understanding
the
link
between
cellular
processes
and
brain
function
remains
a
key
challenge
in
neuroscience.
One
crucial
aspect
is
interplay
specific
ion
channels
network
dynamics.
This
work
reveals
role
for
h‐current,
hyperpolarization‐activated
cationic
current,
shaping
cortical
slow
oscillations.
Cortical
oscillations
are
generated
not
only
during
wave
sleep
deep
anaesthesia,
but
also
association
with
disorders
of
consciousness
lesions.
exhibit
rhythmic
periods
activity
(Up
states)
alternating
silent
(Down
states).
By
progressively
reducing
h‐current
both
slices
computational
model,
we
observed
Up
states
transformed
into
prolonged
plateaus
sustained
firing,
while
Down
were
significantly
extended.
transformation
led
to
fivefold
reduction
oscillation
frequency.
In
biophysical
recurrent
identified
mechanisms
underlying
this
dynamics:
an
increased
neuronal
input
resistance
membrane
time
constant,
increasing
responsiveness
even
weak
inputs.
A
partial
block
therefore
resulted
change
state.
HCN
(hyperpolarization‐activated
cyclic
nucleotide‐gated)
channels,
which
generate
known
targets
neuromodulation,
suggesting
potential
pathways
dynamic
control
rhythms.
image
Key
points
We
investigated
emergent
dynamics,
specifically
states,
slices.
Blocking
lasting
up
4
s.
elongated
oscillatory
frequency
decreased.
model
replicated
these
findings
allowed
us
explore
mechanisms.
An
increase
constant
rise
excitability,
synaptic
firing
rates.
Our
results
highlight
significant
controlling
patterns,
making
it
relevant
target
neuromodulators
regulating
states.
Language: Английский
Neural models for detection and classification of brain states and transitions
Communications Biology,
Journal Year:
2025,
Volume and Issue:
8(1)
Published: April 11, 2025
Exploring
natural
or
pharmacologically
induced
brain
dynamics,
such
as
sleep,
wakefulness,
anesthesia,
provides
rich
functional
models
for
studying
states.
These
allow
detailed
examination
of
unique
spatiotemporal
neural
activity
patterns
that
reveal
function.
However,
assessing
transitions
between
states
remains
computationally
challenging.
Here
we
introduce
a
pipeline
to
detect
and
their
in
the
cerebral
cortex
using
dual-model
Convolutional
Neural
Network
(CNN)
self-supervised
autoencoder-based
multimodal
clustering
algorithm.
This
approach
distinguishes
slow
oscillations,
microarousals,
wakefulness
with
high
confidence.
Using
chronic
local
field
potential
recordings
from
rats,
our
method
achieved
global
accuracy
91%,
up
96%
certain
For
transitions,
report
an
average
74%.
Our
were
trained
leave-one-out
methodology,
allowing
broad
applicability
across
subjects
pre-trained
deployments.
It
also
features
confidence
parameter,
ensuring
only
highly
cases
are
automatically
classified,
leaving
ambiguous
unsupervised
classifier
further
expert
review.
presents
reliable
efficient
tool
state
labeling
analysis,
applications
basic
clinical
neuroscience.
Language: Английский
Pharmacological therapies for early and long-term recovery in disorders of consciousness: current knowledge and promising avenues
Expert Review of Neurotherapeutics,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 21
Published: May 7, 2025
Disorders
of
consciousness
(DoC)
are
characterized
by
impaired
arousal
and/or
awareness,
ranging
from
coma
to
unresponsive
wakefulness
syndrome,
minimally
conscious
state,
and
cognitive
motor
dissociation.
Pharmacological
treatment
options
remain
limited,
complicated
the
heterogeneity
etiologies,
such
as
traumatic
brain
injury,
stroke,
infections.
The
lack
rigorous
clinical
trials
has
led
off-label
use
treatments,
often
without
clear
mechanistic
understanding,
posing
challenges
for
effective
patient
care.
In
this
perspective,
authors
report
on
key
studies
concerning
effectiveness
pharmacological
interventions,
including
dopaminergic
GABAergic
agents,
antidepressants,
statins,
anticonvulsants,
in
promoting
recovery
DoC.
Robust
longitudinal
needed,
with
priority
given
early
subacute
phase
intervention.
Outcomes
should
be
better
defined,
considering
immediate
responses
medication
while
also
increasing
emphasis
long-term
quality
life.
Unified
functional
frameworks
needed
guide
research
foster
collaboration.
Furthermore,
a
shift
toward
personalized
medicine
would
benefit
heterogeneous
population.
Moving
forward,
assessing
efficacy
more
unconventional
or
'paradoxical'
plans
will
essential.
expect
an
increased
AI
tools
identify
factors
that
best
predict
responses.
Language: Английский