Alterations in topology, cost and dynamics of gamma-band EEG functional networks in a preclinical model of traumatic brain injury DOI Creative Commons

Konstantinos Tsikonofilos,

Michael Bruyns‐Haylett, Hazel G May

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Traumatic brain injury is a major cause of disability leading to multiple sequelae in cognitive, sensory, and physical domains, including post-traumatic epilepsy. Despite extensive research, our understanding its impact on macroscopic circuitry remains incomplete. We analyzed electrophysiological functional connectomes the gamma band using preclinical model blast-induced traumatic over time points after injury. revealed differences small-world propensity rich-club structure compared age-matched controls, indicating reorganization following further investigated cost-efficiency trade-offs, propose computationally efficient normalization procedure for quantifying cost spatially embedded networks that controls connectivity strength differences, suggest metabolic drivers as candidate observed differences. Furthermore, we employed brain-wide computational seizure dynamics attribute homeostatic mechanism activity regulation with potential unintended consequence driving generalized seizures. Finally, demonstrated post-injury hyperexcitability manifests an increase sound-evoked response amplitudes at cortical level. Our work characterizes first gamma-band network proposes causes these changes, thus identifying targets future therapeutic interventions.

Language: Английский

Alterations in topology, cost and dynamics of gamma-band EEG functional networks in a preclinical model of traumatic brain injury DOI Creative Commons

Konstantinos Tsikonofilos,

Michael Bruyns‐Haylett, Hazel G May

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Traumatic brain injury is a major cause of disability leading to multiple sequelae in cognitive, sensory, and physical domains, including post-traumatic epilepsy. Despite extensive research, our understanding its impact on macroscopic circuitry remains incomplete. We analyzed electrophysiological functional connectomes the gamma band using preclinical model blast-induced traumatic over time points after injury. revealed differences small-world propensity rich-club structure compared age-matched controls, indicating reorganization following further investigated cost-efficiency trade-offs, propose computationally efficient normalization procedure for quantifying cost spatially embedded networks that controls connectivity strength differences, suggest metabolic drivers as candidate observed differences. Furthermore, we employed brain-wide computational seizure dynamics attribute homeostatic mechanism activity regulation with potential unintended consequence driving generalized seizures. Finally, demonstrated post-injury hyperexcitability manifests an increase sound-evoked response amplitudes at cortical level. Our work characterizes first gamma-band network proposes causes these changes, thus identifying targets future therapeutic interventions.

Language: Английский

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