Association between cardiorespiratory fitness and total brain myelin volume among older adults DOI Creative Commons
M. Kujawa, Małgorzata Grzywińska, Angelika K. Sawicka

et al.

European Review of Aging and Physical Activity, Journal Year: 2025, Volume and Issue: 22(1)

Published: April 8, 2025

Abstract Background Myelin, which insulates neurons, speeds up information transfer and provides the necessary conditions for cognitive motor functioning. The direct link between physical performance total brain myelin volume remains unclear. Methods This study involved 87 healthy participants (71 women, 16 men) with a mean age of 69.3 ± 3.14 years body mass index 27.83 3.93 kg/m 2 . Several measures fitness (isometric muscle strength, handgrip cardiopulmonary exercise testing) were examined their correlations using Synthetic MRI, an FDA-approved assessment software. Results A high maximal respiratory exchange ratio low heart rate achieved during testing associated higher estimated content. In addition, strength test as well peak average torque parenchymal volumes. Conclusions We demonstrated that content was positively better cardiorespiratory upper lower limb in older individuals. These findings provide new insights into development improved rehabilitation schemes to preserve health adult population.

Language: Английский

Age-Related Differences in the Choroid Plexus Structural Integrity Are Associated with Changes in Cognition DOI Creative Commons
Zhaoyuan Gong, Alexandre Rouen, Nathan Zhang

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

The choroid plexus (CP) plays a critical role in maintaining central nervous system (CNS) homeostasis, producing cerebrospinal fluid, and regulating the entry of specific substances into CNS from blood. CP dysfunction has been implicated various neurological psychiatric disorders, including Alzheimer's disease, Parkinson's multiple sclerosis. This study investigates relationship between structural integrity cognitive decline normative aging, using advanced magnetic resonance imaging techniques, volume, diffusion tensor indices (mean diffusivity, MD, fractional anisotropy, FA) relaxometry metrics (longitudinal, T 1 , transverse, 2 relaxation times). Our results show that diminished microstructural integrity, as reflected by higher MD values, or lower FA is associated with performance processing speed fluency. Notably, measures demonstrated greater sensitivity to than macrostructural measures, i.e. volume. Longitudinal analysis revealed individuals reduced exhibit steeper over time. Furthermore, equation modeling latent variable representing predicts faster overall decline, an effect size comparable age. These findings highlight importance health suggest holistic approach assessing could serve sensitive biomarker for early detection decline. Further research needed elucidate mechanisms underlying explore potential therapeutic implications targeting function prevent treat age-related deficits.

Language: Английский

Citations

0
Association between cardiorespiratory fitness and total brain myelin volume among older adults DOI Creative Commons
M. Kujawa, Małgorzata Grzywińska, Angelika K. Sawicka

et al.

European Review of Aging and Physical Activity, Journal Year: 2025, Volume and Issue: 22(1)

Published: April 8, 2025

Abstract Background Myelin, which insulates neurons, speeds up information transfer and provides the necessary conditions for cognitive motor functioning. The direct link between physical performance total brain myelin volume remains unclear. Methods This study involved 87 healthy participants (71 women, 16 men) with a mean age of 69.3 ± 3.14 years body mass index 27.83 3.93 kg/m 2 . Several measures fitness (isometric muscle strength, handgrip cardiopulmonary exercise testing) were examined their correlations using Synthetic MRI, an FDA-approved assessment software. Results A high maximal respiratory exchange ratio low heart rate achieved during testing associated higher estimated content. In addition, strength test as well peak average torque parenchymal volumes. Conclusions We demonstrated that content was positively better cardiorespiratory upper lower limb in older individuals. These findings provide new insights into development improved rehabilitation schemes to preserve health adult population.

Language: Английский

Citations

0