Microneedles as Transdermal Drug Delivery System for Enhancing Skin Disease Treatment

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(12), P. 5161 - 5180

Published: Aug. 23, 2024

Microneedles (MNs) serve as a revolutionary paradigm in transdermal drug delivery, heralding viable resolution to the formidable barriers presented by cutaneous interface. This review examines MNs an advanced approach enhancing dermatological pathology management. It explores complex dermis structure and highlights limitations of traditional methods, emphasizing MNs' advantage bypassing stratum corneum deliver drugs directly subdermal matrix. The discourse outlines diverse typologies MNs, including solid, coated, hollow, hydrogel, dissolvable versions. Each type is characterized its unique applications benefits. treatise details deployment alleviation cancers, administration inflammatory dermatoses such psoriasis atopic dermatitis, their utility wound Additionally, paper contemplates prospects within realm aesthetic dermatology burgeoning market traction cosmetic MN formulations. summarizes scientific commercial challenges clinical adoption therapeutics, dosage calibration, pharmacodynamics, biocompatibility, patient compliance, sterilization, mass production, regulatory oversight. emphasizes need for ongoing research, innovation, harmonization overcome these obstacles fully realize potential treating skin diseases improving welfare. presents comprehensive overview recent accomplishments, remaining challenges, future microneedle-facilitated therapy afflictions.

Language: Английский

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pH-Responsive Hydrogel with Dual-crosslinked Network of Polyvinyl Alcohol/Boric Acid for Controlled Release of Salvianolic Acid B: Novel Pro-Regenerative Mechanisms in Scar Inhibition and Wound Healing

Regenerative Biomaterials, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 1, 2025

Abstract This study investigates a novel pH-responsive hydrogel composed of polyvinyl alcohol (PVA) and boric acid (BA) designed for the controlled release salvianolic B (SAB), addressing critical challenge scar formation skin regeneration. The dual-crosslinked network architecture exhibits remarkable pH sensitivity, enabling it to achieve peak SAB within 48 hours in acidic microenvironment characteristic early-stage wound healing. In vitro assessments demonstrated that PVA-BA-SAB significantly inhibits fibroblast activation mitigates abnormal collagen deposition, effectively preventing excessive formation. Transcriptome sequencing reveals potential role balancing TGF-β Wnt signaling pathways. Furthermore, vivo studies revealed enhanced tissue regeneration, characterized by improved organization increased vascularization, as well promotion mature hair follicle development. hydrogel’s biocompatibility, mechanical robustness adhesive properties were also thoroughly evaluated, confirming its suitability clinical applications. These findings suggest fully exerts excellent characteristics biomaterials maximizes pharmacological effect SAB. Our innovative drug delivery system not only facilitates healing but offers strategic approach minimize scarring. research provides valuable insights into therapeutic strategies effective management repair.

Language: Английский

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Comprehensive Insights into Keloid Pathogenesis and Advanced Therapeutic Strategies

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(16), P. 8776 - 8776

Published: Aug. 12, 2024

Keloid scars, characterized by abnormal fibroproliferation and excessive extracellular matrix (ECM) production that extends beyond the original wound, often cause pruritus, pain, hyperpigmentation, significantly impacting quality of life. pathogenesis is multifactorial, involving genetic predisposition, immune response dysregulation, aberrant wound-healing processes. Central molecular pathways such as TGF-β/Smad JAK/STAT are important in keloid formation sustaining fibroblast activation ECM deposition. Conventional treatments, including surgical excision, radiation, laser therapies, intralesional injections, yield variable success but limited high recurrence rates potential adverse effects. Emerging therapies targeting specific pathways, small molecule inhibitors, RNA interference, mesenchymal stem cells show promise disrupting underlying mechanisms pathogenesis, potentially offering more effective lasting treatment outcomes. Despite advancements, further research essential to fully elucidate precise develop targeted therapies. Ongoing clinical trials efforts vital for translating these scientific insights into practical treatments can markedly enhance life individuals affected scars.

Language: Английский

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Advances in skin gene therapy: utilizing innovative dressing scaffolds for wound healing, a comprehensive review

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(25), P. 6033 - 6062

Published: Jan. 1, 2024

Gene-activated matrices are versatile and novel technologies to treat skin wounds. This approach offers a promising avenue for targeted treatment strategies in health care.

Language: Английский

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Laser-assisted corticoid delivery for the treatment of burn scars

European Journal of Plastic Surgery, Journal Year: 2025, Volume and Issue: 48(1)

Published: Jan. 20, 2025

Language: Английский

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Photoinduced Chemiluminescence Determination of Prednisolone Using Lucigenin‐Cobalt 5,10,15,20‐Tetra(4‐Pyridyl)‐21H,23H‐Porphine System

Luminescence, Journal Year: 2025, Volume and Issue: 40(1)

Published: Jan. 1, 2025

ABSTRACT Sensitive and precise assay of prednisolone, a steroid hormone, has received great attention due to its significant role in the treatment series diseases. In this study, we have developed simple, quick, accurate technique part measure prednisolone. Cobalt 5,10,15,20‐tetra(4‐pyridyl)‐21H,23H‐porphine (CoTPyP) as mimic peroxidase catalyzes chemiluminescence (CL) reaction lucigenin for first time. CoTPyP impact on CL signal. Furthermore, system been successfully used prednisolone flow‐injection test. The findings showed that UV irradiation led an unimolecular photochemical could enhance yield high‐energy intermediate cause higher emission. Under ideal experimental circumstances, intensity was shown be proportionate concentration range 0.1–170 μg mL −1 ( r = 0.9925, n 4). A detection limit 0.072 observed. Compared with HPLC approach, our proposed method provides sensitive, fast, efficient analysis pharmaceutical formulations biological fluids.

Language: Английский

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Skin microincision technique to enhance drug penetration for the treatment of keloid and hypertrophic scars

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125259 - 125259

Published: Jan. 1, 2025

Language: Английский

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Artesunate attenuates skin hypertrophic scar formation by inhibiting fibroblast activation and EndMT of vascular endothelial cells

Phytomedicine, Journal Year: 2025, Volume and Issue: 140, P. 156498 - 156498

Published: Feb. 14, 2025

Language: Английский

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Enhanced scar mitigation via hyperbaric oxygen therapy and immune modulation using nanoparticle-orchestrated photosynthetic chlorella in polysaccharide hydrogels

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160666 - 160666

Published: Feb. 1, 2025

Language: Английский

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Scoping review for pain mitigation during intralesional injections of corticosteroid for hypertrophic scar and keloid treatment

BMJ Open, Journal Year: 2025, Volume and Issue: 15(2), P. e092800 - e092800

Published: Feb. 1, 2025

Background Intralesional corticosteroid injection (ILCSI) has been proven to successfully treat hypertrophic scars (HTSs) and keloids attain remission in 50% of keloids. Pain is a significant problem with ILCSI, which can affect treatment compliance effectiveness. To date, many techniques involving ILCSI have described used achieve scar while reducing side effects. The technique remains the most widely available method healthcare centres. Objective This scoping review explores strategies for alleviating pain administering ILCSIs scarring keloid management. second-line HTSs first-line Eligibility criteria included studies where were treated considered diverse demographics methods. excludes other methods drug delivery not involved assessed unrelated or infiltration scar. Sources evidence systematically searched critical databases from inception December 2023, including ScienceDirect, PubMed Web Science, handpicked articles traced papers. Only English-language publications focused on management during included. All levels scientific considered. An in-depth evaluation technique, type analgesia anaesthesia administered, effectiveness overall outcomes was conducted. Charting Citations compiled an Excel spreadsheet, three authors screening titles abstracts based inclusion criteria. Decisions finalised collaboratively, exclusions documented results presented using Preferred Reporting Items Systematic Reviews Meta-Analyses flow diagram. Results 16 prospective studies, 2 retrospective 1 case study 15 journal These examined treatment. No differences intensity between reported. 11 explored reduction such as topical analgesia, cryoanaesthesia, mixing triamcinolone acetonide local analgesics, slow techniques, vibration needle-free injectors. Conclusion significantly impact patient outcomes. offers foundational reference providers researchers field management, providing insights into current practices highlighting areas future research development.

Language: Английский

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