Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 1, 2024
The
cyclic
GMP-AMP
synthase
(cGAS)-stimulator
of
interferon
genes
(STING)
signaling
pathway
has
been
identified
as
a
crucial
mechanism
in
antiviral
defense
and
innate
immunity
pathway.
Ferroptosis,
characterized
by
iron
dependence
lipid
peroxidation,
represents
specialized
form
cell
death.
A
burgeoning
collection
studies
demonstrated
that
the
cGAS-STING
participates
homeostatic
regulation
organism
modulating
ferroptosis-associated
enzyme
activity
or
gene
expression.
Consequently,
elucidating
specific
roles
STING
ferroptosis
vivo
is
vital
for
targeted
disease
intervention.
This
review
systematically
examines
interactions
between
ferroptosis,
highlighting
their
influence
on
progression
contexts
inflammation,
injury,
cancerous
dynamics.
Understanding
these
may
provide
novel
therapeutic
strategies.
implicated
various
death
mechanisms,
including
apoptosis,
pyroptosis,
necroptosis,
autophagy,
ferroptosis.
Our
focus
primarily
addresses
role
diseases,
limiting
discussion
other
modalities
precluding
comprehensive
overview
pathway's
additional
functions.
International Journal of Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
670, P. 125186 - 125186
Published: Jan. 8, 2025
The
blood-brain
barrier
(BBB)
plays
a
vital
role
in
protecting
the
central
nervous
system
(CNS)
by
preventing
entry
of
harmful
pathogens
from
bloodstream.
However,
this
also
presents
significant
obstacle
when
it
comes
to
delivering
drugs
for
treatment
neurodegenerative
diseases
and
brain
cancer.
Recent
breakthroughs
nanotechnology
have
paved
way
creation
wide
range
nanoparticles
(NPs)
that
can
serve
as
carriers
diagnosis
therapy.
Regarding
their
promising
properties,
organic
NPs
potential
be
used
effective
drug
delivery
across
BBB
based
on
recent
advancements.
These
remarkable
ability
penetrate
using
various
mechanisms.
This
review
offers
comprehensive
examination
intricate
structure
distinct
properties
BBB,
emphasizing
its
crucial
function
preserving
balance
regulating
transport
ions
molecules.
disruption
conditions
such
stroke,
Alzheimer's
disease,
Parkinson's
disease
highlights
importance
developing
creative
approaches
drugs.
Through
encapsulation
therapeutic
molecules
precise
targeting
processes
vasculature,
NP
formulations
present
hopeful
strategy
improve
BBB.
We
explore
changes
pathological
investigate
factors
affect
successful
into
brain.
In
addition,
we
most
systems
associated
with
shown
positive
results
treating
ischemic
disorders.
opens
up
new
possibilities
nanotechnology-based
therapies
cerebral
diseases.
