Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 1, 2024
The
cyclic
GMP-AMP
synthase
(cGAS)-stimulator
of
interferon
genes
(STING)
signaling
pathway
has
been
identified
as
a
crucial
mechanism
in
antiviral
defense
and
innate
immunity
pathway.
Ferroptosis,
characterized
by
iron
dependence
lipid
peroxidation,
represents
specialized
form
cell
death.
A
burgeoning
collection
studies
demonstrated
that
the
cGAS-STING
participates
homeostatic
regulation
organism
modulating
ferroptosis-associated
enzyme
activity
or
gene
expression.
Consequently,
elucidating
specific
roles
STING
ferroptosis
vivo
is
vital
for
targeted
disease
intervention.
This
review
systematically
examines
interactions
between
ferroptosis,
highlighting
their
influence
on
progression
contexts
inflammation,
injury,
cancerous
dynamics.
Understanding
these
may
provide
novel
therapeutic
strategies.
implicated
various
death
mechanisms,
including
apoptosis,
pyroptosis,
necroptosis,
autophagy,
ferroptosis.
Our
focus
primarily
addresses
role
diseases,
limiting
discussion
other
modalities
precluding
comprehensive
overview
pathway's
additional
functions.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 19, 2025
ABSTRACT
γ-Secretase
is
an
intramembrane
protease
complex,
with
nearly
150
substrates
that
are
cleaved
within
their
transmembrane
domains
(TMD).
Amyloid
Precursor
Protein
(APP)
the
most
widely
studied,
as
processive
proteolysis
by
γ-secretase
releases
amyloid-β-peptide
(Aβ)
implicated
in
pathogenesis
of
Alzheimer’s
disease.
In
contrast,
other
has
been
little
explored.
The
only
known
sequence
specificity
rule
for
cleavage
APP,
which
phenylalanine
not
tolerated
at
P2’
respect
to
any
step
proteolysis.
Recently,
we
found
this
applies
initial
Notch1
substrate
well.
study,
examined
site
and
explored
two
substrates:
neuregulin1
(NRG1)
E-cadherin
(CDH1).
Upon
incubation
recombinant
purified
followed
mass
spectroscopy
(MS)
immunoblot
analysis,
products
NRG1
CDH1
were
identified.
Two
sites
observed
TMD,
one
matched
seen
previously.
However,
single
TMD
differed
from
reported
cytosolic
site.
Phenylalanine
mutants
position
relative
first
showed
a
shift
site,
along
reduction
total
C-terminal
N-terminal
products,
compared
wild-type
substrates.
Taking
together,
these
findings
clarify
support
intolerance
Phe
general
For
Table
Contents
use
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
30, P. 101432 - 101432
Published: Dec. 28, 2024
Flap
techniques
are
indispensable
in
modern
surgery
because
of
their
role
repairing
tissue
defects
and
restoring
function.
Ischemia-reperfusion
oxidative
stress-induced
injuries
the
main
causes
flap
failure.
Oxidative
stress
exacerbates
cell
damage
through
accumulation
reactive
oxygen
species
(ROS),
thereby
affecting
function
survival.
Effective
management
these
factors
is
essential
for
improving
survival
post-operative
recovery.
In
this
study,
we
utilized
hollow
mesoporous
cerium
dioxide
nanoparticles
loaded
with
quercetin,
which
were
later
into
a
light-cured
double
cross-linked
hydrogel
(HQu@BC)
injected
site
to
activate
macrophage
reprogramming
maintain
local
ROS
homeostasis
reduce
inflammation.
Quercetin
scavenges
reduces
mitochondrial
due
its
intrinsic
reducing
structures
such
as
catechols,
carbon-carbon
bonds,
hydroxyl
synergistic
nanoparticles,
inhibits
inflammation
by
suppressing
M1
polarization.
This
system
continuously
regulates
levels,
kills
bacteria
ultimately
inflammation,
creating
favorable
microenvironment
innovative
injectable
composite
nanoparticle
material
has
anti-inflammatory,
antioxidant,
antimicrobial,
healing-promoting
properties,
providing
new
approach
success
surgery.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 14, 2024
This
article
provides
a
comprehensive
hemodynamic
assessment
of
two
endovascular
techniques
for
treating
cerebral
aneurysms.
Through
finite
volume
simulations
pulsatile
blood
flow
in
saccular
aneurysms,
we
evaluated
factors
under
coiling
conditions
with
varying
porosities
and
deformation
stages
to
determine
the
most
effective
treatment
each
case.
Our
analysis
shows
that
stent
treatments
are
more
aneurysms
smaller
sac
volumes.
In
particular,
placement
is
found
be
than
managing
The
results
indicate
stent-induced
effectively
redirects
main
flow,
significantly
lowering
risk
aneurysm
rupture
near
ostium.
Obtained
emphasize
role
porosity
controlling
wall
shear
stress,
which
essential
understanding
progression
potential
risk.
Journal of Advanced Research,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 1, 2024
The
cyclic
GMP-AMP
synthase
(cGAS)-stimulator
of
interferon
genes
(STING)
signaling
pathway
has
been
identified
as
a
crucial
mechanism
in
antiviral
defense
and
innate
immunity
pathway.
Ferroptosis,
characterized
by
iron
dependence
lipid
peroxidation,
represents
specialized
form
cell
death.
A
burgeoning
collection
studies
demonstrated
that
the
cGAS-STING
participates
homeostatic
regulation
organism
modulating
ferroptosis-associated
enzyme
activity
or
gene
expression.
Consequently,
elucidating
specific
roles
STING
ferroptosis
vivo
is
vital
for
targeted
disease
intervention.
This
review
systematically
examines
interactions
between
ferroptosis,
highlighting
their
influence
on
progression
contexts
inflammation,
injury,
cancerous
dynamics.
Understanding
these
may
provide
novel
therapeutic
strategies.
implicated
various
death
mechanisms,
including
apoptosis,
pyroptosis,
necroptosis,
autophagy,
ferroptosis.
Our
focus
primarily
addresses
role
diseases,
limiting
discussion
other
modalities
precluding
comprehensive
overview
pathway's
additional
functions.
