A Comprehensive Review of Niobium Nanoparticles: Synthesis, Characterization, Applications in Health Sciences, and Future Challenges

Nanomaterials, Journal Year: 2025, Volume and Issue: 15(2), P. 106 - 106

Published: Jan. 12, 2025

Niobium nanoparticles (NbNPs) have gained attention as promising materials in biomedical applications due to their exceptional biocompatibility, corrosion resistance, and versatility. These offer potential drug delivery, imaging, tissue engineering, where nanoscale properties allow precise interactions with biological systems. Among niobium-based nanomaterials, niobium pentoxide (Nb2O5) is the most extensively studied its chemical stability, bioactivity, optical properties. Nb2O5 shown significant catalysis, biosensing, photodynamic therapy, stability reactivity make them ideal for functionalization advanced applications. Despite these advantages, challenges remain regarding biodegradability long-term retention of NbNPs Their accumulation tissues can lead risks such chronic inflammation or toxicity, emphasizing importance designing controlled clearance biodegradability. Surface modifications, coatings biocompatible polymers, demonstrated ability mitigate while enhancing therapeutic efficacy. This review provides a comprehensive overview NbNPs, focus on Nb2O5, highlighting unique properties, current applications, limitations. By addressing remaining challenges, this work aims guide development safer more effective nanomaterials future medical innovations.

Language: Английский

Regulatory role of CD177+ neutrophils in BMP signaling pathway and its implications for inflammatory bowel disease, sepsis, and intestinal tumors

Translational Oncology, Journal Year: 2025, Volume and Issue: 55, P. 102336 - 102336

Published: April 1, 2025

Language: Английский

Multifunctional Silk Fibroin Nanocarriers Loaded with Chlorin e6 for PDT/PTT Synergistic Elimination of Drug-Resistant Bacteria and Biofilms

ACS Infectious Diseases, Journal Year: 2025, Volume and Issue: unknown

Published: June 1, 2025

The development of drug-resistant biofilms has resulted in treatment failures for multidrug resistant (MDR) bacteria, presenting a substantial challenge to global public health. Consequently, the antibacterial agents become an urgent priority. To overcome limitations poor penetration and inadequate efficacy single-modal treatments MDR bacterial biofilm infections, this study developed Ce6/SFP nanocomposite system utilizing silk fibroin polydopamine. nanoparticles, fabricated via desolvation-in situ polymerization method, demonstrated pH-responsive drug release properties. When subjected 808 nm NIR laser, material exhibited photothermal conversion efficiency 29.3%. Furthermore, when paired with singlet oxygen produced through 660 excitation, it was highly effective eliminating Escherichia coli Staphylococcus aureus. synergistic effect therapy (PTT) photodynamic (PDT) disrupted stability cell membrane enhanced efficacy. Experimental results showed that increased permeability, significantly improving Ce6 depth. Moreover, vivo accelerated wound healing. Biocompatibility assessments revealed hemolysis rate below 5% no pathological damage major organs. This proposes strategy effectively address challenges posed by resistance.

Language: Английский