Application of Metabolomics in Carcinogenesis and Cancer Prevention by Dietary Phytochemicals
Rebecca Mary Peter,
No information about this author
Xiaoyang Su,
No information about this author
Ah‐Ng Tony Kong
No information about this author
et al.
Current Pharmacology Reports,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: Feb. 6, 2025
In
this
review
article,
specific
emphasis
is
on
evolution
of
metabolomics
in
cancer
research,
workflow,
general
understanding
liquid
chromatography
-
mass
spectrometry
(LC-MS)
based
platform
for
quantitation
metabolites,
their
biological
interpretation
and
the
application
carcinogenesis
prevention
by
dietary
phytochemicals.
Metabolomics
increasingly
becoming
a
preferred
approach
next
generation
metabolic
screening
has
profound
impact
medical
practice.
describes
end
products
biochemical
processes
which
are
greatly
influenced
genetic
environmental
factors.
Metabolic
alterations
can
be
linked
to
potential
reactions/enzymes
corresponding
genes.
Thus,
these
results
further
validated
via
multi-omics
including
genomics,
transcriptomics
proteomics.
However,
challenges
exist
within
between
omic-domain
data
integration
considering
complex
regulation
organism
versus
tissue
cellular
level
processes,
epigenetics,
transcriptional
post
translational
modifications.
reflect
steady
state
or
dynamic
metabolism
because
metabolites
highly
space
time.
Metabolomic
analysis
samples
exhibit
possibility
determine
mechanism
action
anti-cancer
agents,
biomarker
discovery
alterations.
Language: Английский
The Role of Medicinal Plants in Modulating Epigenetic Mechanisms: Implications for Cancer Prevention and Therapy
Khadra Afaf Bendrihem,
No information about this author
Aicha Mouane,
No information about this author
Manel Azzi
No information about this author
et al.
Phytotherapy Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 4, 2025
Cancer
remains
a
significant
global
health
challenge,
with
its
progression
driven
by
both
genetic
mutations
and
reversible
epigenetic
modifications.
This
review
highlights
the
potential
of
phytochemicals
to
modulate
mechanisms
for
cancer
prevention
treatment.
Natural
compounds
such
as
quercetin,
EGCG,
genistein,
β-elemene
interact
key
processes
DNA
methylation,
histone
modifications,
non-coding
RNA
regulation.
These
enable
reactivation
tumor
suppressor
genes,
increased
sensitivity
conventional
therapy
mitigation
drug
resistance.
For
instance,
EGCG
improves
efficacy
cisplatin
altering
methylation
patterns,
while
genistein
influences
breast
through
HER2
pathway
However,
challenges
low
bioavailability,
variability
in
compound
composition,
need
robust
clinical
validation
remain.
Further
high-quality
trials
are
required
confirm
safety
these
therapy.
Language: Английский
Cyproheptadine inhibits in vitro and in vivo lung metastasis and drives metabolic rewiring
Molecular Biology Reports,
Journal Year:
2024,
Volume and Issue:
51(1)
Published: Nov. 10, 2024
Non-small
cell
lung
cancer
(NSCLC)
accounts
for
81%
of
cases,
among
which
over
47%
presented
with
distant
metastasis
at
the
time
diagnosis.
Despite
introduction
targeted
therapy
and
immunotherapy,
enhancing
survival
rate
overcoming
development
resistance
remain
a
big
challenge.
Thus,
it
is
crucial
to
find
potential
new
therapeutics
targets
that
can
mitigate
investigate
its
effects
on
biomarkers,
such
as
cellular
metabolomics.
In
current
study,
we
investigated
role
cyproheptadine
(CPH),
an
FDA-approved
anti-histamine
drug
in
vitro
vivo.
Language: Английский
A New Perspective on the Molecular Targets, Mechanisms of Action, and Clinical Significance of Ursolic Acid’s Multifaceted Anti-Cancer Effects
Md. Rezaul Islam,
No information about this author
Abdur Rauf,
No information about this author
Shopnil Akash
No information about this author
et al.
Current Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
29(2), P. 85 - 96
Published: Aug. 7, 2024
:
A
pentacyclic
triterpenoid
produced
from
medicinal
herbs,
fruits,
and
vegetables,
Ursolic
acid
(UA)
has
pharmacological
activity.
This
review
provides
a
comprehensive
overview
of
the
interactions
UA
with
molecular
targets,
its
various
mechanisms
action,
clinical
implications
in
cancer
therapy.
Numerous
studies
have
been
conducted
on
effects
UA,
biological
benefits,
such
as
antiinflammatory,
antioxidant,
anti-cancer
activities,
demonstrated.
The
study
showed
how
signaling
pathways,
PI3K/Akt,
MAPK,
NF-κB,
work
together
to
control
cell
death,
proliferation,
inflammation.
effectively
treats
by
interacting
targets
making
it
potent
treatment
option.
It
inhibits
tumor
transformation,
limits
their
reproduction
ability,
triggers
apoptosis.
also
found
inhibit
pro-inflammatory
transcription
factors
cycle
proteins,
kinases,
cytokines,
chemokines,
adhesion
molecules,
inflammatory
enzymes.
may
aid
UA's
chemopreventive
therapeutic
benefits
preventing
initiation,
growth,
metastasis.
proliferation
arresting
triggering
apoptosis
through
cycle.
is
promising
anticancer
agent
action.
Additionally,
can
target
multiple
pathways
influence
microenvironment,
suggesting
potential
complementary
therapy
treatment.
Further
investigations
are
needed
entirely
understand
optimize
application
cancer.
explores
insights
into
activities.
Language: Английский
Ursolic Acid as a Protective Agent Against UVB-Induced Metabolic and Epigenetic Alterations in Human Skin Keratinocytes: An Omics-Based Study
Cancer Prevention Research,
Journal Year:
2024,
Volume and Issue:
18(3), P. 135 - 144
Published: Dec. 24, 2024
This
study
aimed
to
assess
how
ursolic
acid
(UA)
can
protect
human
skin
keratinocytes
from
damage
caused
by
UVB
radiation.
Utilizing
an
omics-based
approach,
we
characterized
the
features
of
photodamage
and
investigated
potential
UA
reverse
HaCaT
cell
subpopulation
injury
The
most
significant
changes
in
metabolite
levels
after
treatment
were
pathways
associated
with
phosphatidylcholine
biosynthesis
arginine
proline
metabolism.
Treatment
certain
metabolites,
including
creatinine,
creatine
phosphate,
succinic
acid.
Pathways
activated
UVB-irradiated
cells
several
biological
processes,
positive
regulation
protein
modification
process,
division,
enzyme-linked
receptor
signaling
pathway.
demonstrates
capability
mitigate
effects
radiation
on
specific
genes,
S100
calcium-binding
A9
IL6
receptor.
DNA/CpG
methylation
indicates
that
partially
some
alterations
UVB-induced
CpG
methylome.
integrated
RNA
sequencing
data,
starburst
plots
illustrate
correlation
between
mRNA
expression
status.
potentially
influences
metabolic
pathway
glycerophospholipid
metabolism
modulating
key
enzymes,
phospholipase
A2
group
IIA
lipin
2.
Altogether,
these
results
indicate
induces
reprogramming,
epigenetic
changes,
transcriptomic
shifts.
Meanwhile,
capacity
inhibit
or
reduce
severity
alterations,
which
may
underlie
its
protective
role
against
exposure.
Prevention
Relevance:
Our
research
has
lessen
impact
radiation,
is
known
cause
changes.
These
could
be
responsible
for
UA's
possible
function
induced
Language: Английский