Epithelial-mesenchymal Transition Promotes Metabolic Reprogramming to Suppress Ferroptosis

Seminars in Cancer Biology, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Integration of Fatty Acid-Targeted Metabolome and Transcriptomics Reveals the Mechanism of Chronic Environmental Microcystin-LR-Induced Hepatic Steatosis

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

Microcystin-LR (MC-LR) is a toxin that causes hepatic steatosis. Our previous study found exposure to 60 μg/L MC-LR for 9 months resulted in liver lipid accumulation, but the underlying mechanisms remain elusive. Herein, first time, fatty acid-targeted metabolome and RNA-seq were combined probe effect mechanism of chronic (12-month) treatment on mice metabolism at environmental-related levels (1, 60, 120 μg/L). It was dose-dependently raised serum levels. The total cholesterol (TC) significantly increased following with 1 (equivalent 0.004 μ/L human). Treatment elevated TC triglyceride (TG) both liver. Serum analysis demonstrated 1, caused significant alterations acid profile. Chronic polyunsaturated acids (PUFAs), including conjugated linoleic eicosapentaenoic acid, which positively correlated or TG led decrease accumulation saturated acids, citramalic pentadecanoic docosanoic negatively These findings suggested mild disruption, while pronounced steatosis mice. Transcriptome revealed environmental regulated expression genes involved phosphatidylinositol 3-kinase (PI3K) complex metabolism. Western blotting RT-qPCR confirmed activated PI3K/AKT/mTOR signaling pathway, downstream fads3 gene participates desaturation upregulated, degradation-related genes, acsl1, acsl4, ehhadh inhibited, transport-related slc27a4 apol7a, promoted. Thus, boosts work indicated limit concentration human drinking water safety needs be discussed. provides evidence profile changes gains new insights into treatment-induced

Language: Английский

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The pathogenesis mechanism and potential clinical value of lncRNA in gliomas

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: July 5, 2024

Abstract Glioma is the most common malignant tumor in central nervous system, and its unique pathogenesis often leads to poor treatment outcomes prognosis. In 2021, World Health Organization (WHO) divided gliomas into five categories based on their histological characteristics molecular changes. Non-coding RNA a type of that does not encode proteins but can exert biological functions at level, long non-coding (lncRNA) with length exceeding 200 nt. It controlled by various transcription factors plays an indispensable role regulatory processes cells. Numerous studies have confirmed dysregulation lncRNA critical pathogenesis, progression, malignancy gliomas. Therefore, this article reviews proliferation, apoptosis, invasion, migration, angiogenesis, immune regulation, glycolysis, stemness, drug resistance changes caused gliomas, summarizes potential clinical significance

Language: Английский

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Identification of a ferroptosis-related prognostic signature and validation of ITGA6-AS1 in enhancing cell proliferation, migration and invasion in glioma

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 137, P. 112438 - 112438

Published: June 13, 2024

Language: Английский

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