Discovery of prognostic lncRNAs in colorectal cancer using spatial transcriptomics DOI Creative Commons
Holly R. Pinkney,

Cody R. Ross,

Timothy O. Hodgson

et al.

npj Precision Oncology, Journal Year: 2024, Volume and Issue: 8(1)

Published: Oct. 10, 2024

Colorectal cancer (CRC) exhibits significant genetic and epigenetic diversity, evolving into sub-clonal populations with varied metastatic potentials treatment responses. Predicting disease in CRC patients remains challenging, underscoring the need for reliable biomarkers. While most research on therapeutic targets biomarkers has focused proteins, non-coding RNAs such as long (lncRNAs) comprise of transcriptome demonstrate superior tissue- cancer-specific expression. We utilised spatial transcriptomics to investigate lncRNAs tumours, offering more precise cell-type-specific expression data compared bulk RNA sequencing. Our analysis identified 301 linked malignant regions, which we validated public data. Further validation using RNA–FISH revealed three (LINC01978, PLAC4, LINC01303) that are detectable stage II tumours but not normal epithelium upregulated tissues. These hold potential early risk assessment disease.

Language: Английский

Macrophage-derived lncRNAs in cancer: regulators of tumor progression and therapeutic targets DOI
Muath Suliman, Raed Obaid Saleh,

M Chandra

et al.

Medical Oncology, Journal Year: 2025, Volume and Issue: 42(4)

Published: March 6, 2025

Language: Английский

Citations

0
Role of long non-coding RNAs in the regulation of ferroptosis in tumors DOI Creative Commons

Ying Ju,

Yuanhao Lv,

Xu Liu

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: March 21, 2025

Normal cells begin to grow indefinitely and immortalize form tumor after an external stimulus resulting in a genetic mutation. Effective killing of is the basis various cancer therapies. Ferroptosis class cell death types dependent on iron cellular lipid peroxidation. Tumors themselves are iron-dependent, conventional radiotherapy also sensitizes ferroptosis. Increasing sensitivity ferroptosis may be potential therapeutic strategy overcome resistance mechanisms therapy. Long noncoding RNAs (LncRNAs) transcripts more than 200 nucleotides length that regulate gene expression at multiple levels involved biological processes such as differentiation, cycle arrest, maintenance stemness. Recent studies have found lncRNAs through influence or ameliorate chemotherapeutic agents. With continuous maturation nanomaterials technology, it provide new means for treatment by regulating ferroptosis-related inside tumors well increasing Fe 2+ ROS tumors. In this paper, we systematically introduce regulatory mechanism ferroptosis, role immunotherapy application combined with nanomaterials, which provides perspectives

Language: Английский

Citations

0
Regulation of immune-mediated chemoresistance in cancer by lncRNAs: an in-depth review of signaling pathways DOI
Saade Abdalkareem Jasim, Farag M. A. Altalbawy, Subasini Uthirapathy

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Language: Английский

Citations

0
Discovery of prognostic lncRNAs in colorectal cancer using spatial transcriptomics DOI Creative Commons
Holly R. Pinkney,

Cody R. Ross,

Timothy O. Hodgson

et al.

npj Precision Oncology, Journal Year: 2024, Volume and Issue: 8(1)

Published: Oct. 10, 2024

Colorectal cancer (CRC) exhibits significant genetic and epigenetic diversity, evolving into sub-clonal populations with varied metastatic potentials treatment responses. Predicting disease in CRC patients remains challenging, underscoring the need for reliable biomarkers. While most research on therapeutic targets biomarkers has focused proteins, non-coding RNAs such as long (lncRNAs) comprise of transcriptome demonstrate superior tissue- cancer-specific expression. We utilised spatial transcriptomics to investigate lncRNAs tumours, offering more precise cell-type-specific expression data compared bulk RNA sequencing. Our analysis identified 301 linked malignant regions, which we validated public data. Further validation using RNA–FISH revealed three (LINC01978, PLAC4, LINC01303) that are detectable stage II tumours but not normal epithelium upregulated tissues. These hold potential early risk assessment disease.

Language: Английский

Citations

2