LncRNAs Regulate Vasculogenic Mimicry in Human Cancers DOI Creative Commons
Eloísa Ibarra-Sierra, Mercedes Bermúdez, Carlos Esteban Villegas‐Mercado

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 616 - 616

Published: April 20, 2025

Vasculogenic mimicry (VM) has recently been discovered as an alternative mechanism for nourishing cancer cells in vivo. During VM, tumor align and organize themselves into three-dimensional (3D) channel-like structures to transport nutrients oxygen the internal layers of tumors. This mainly occurs aggressive solid tumors associated with poor prognosis oncologic patients. Long non-coding RNAs (lncRNAs) are essential regulators protein-encoding genes involved development progression. These single-stranded RNA molecules regulate critical cellular functions including cell proliferation, apoptosis, angiogenesis, therapy response, migration, invasion, metastasis. Recently, high-throughput RNA-sequencing technologies have identified thousands lncRNAs, but only a small percentage them functionally characterized human cancers. The vast amount data about its genomic expression can allow us dissect their biology make suitable biomarkers diagnosis prognosis. In this study, we reviewed current knowledge role lncRNAs regulating VM cancer. We also examined molecular mechanisms highlight several commonalities between diverse types. Future directions research focused on deciphering function delineated. Finally, potential selected novel therapeutic targets RNA-based interventions is discussed.

Language: Английский

Research Progress of Long Non-Coding RNAs in Gastric Cancer Angiogenesis DOI

攀 刘

Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 2240 - 2245

Published: Jan. 1, 2025

Language: Английский

Citations

0
Increased keratin 80 expression predicts poor prognosis and promotes oxaliplatin resistance in gastric cancer DOI
Bo Yang, Hongxia Cao, Yulong He

et al.

World Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: 31(12)

Published: March 26, 2025

BACKGROUND Keratin 80 (KRT80), a type I intermediate filament protein, is member of the keratin family with specialized functions in epithelial tissues. While KRT80 has been implicated both normal physiological processes and various diseases, its role gastric cancer (GC), particularly expression prognostic significance, remains poorly understood. In this study, we investigated underlying molecular mechanisms oxaliplatin resistance GC. Our analysis revealed that significantly upregulated GC tissues associated poor clinical prognosis. The cell proliferation was assessed through vitro vivo assays. AIM To explore impact on prognosis patients. METHODS analyzed using Western blotting, quantitative reverse transcription PCR, multiple immunofluorescence staining, immunohistochemistry. Survival conducted Kaplan-Meier method log-rank test. Immunoprecipitation mass spectrometry analyses identified elongation factor 1-alpha 1 (EEF1A1) as binding protein KRT80. RESULTS Integrating our experimental findings published studies, found increased promotes to oxaliplatin. Moreover, have preliminarily verified interaction between EEF1A1. Therefore, study provides novel perspective overcoming CONCLUSION Increased predicts GC, suggesting potential biomarker.

Language: Английский

Citations

0
LncRNAs Regulate Vasculogenic Mimicry in Human Cancers DOI Creative Commons
Eloísa Ibarra-Sierra, Mercedes Bermúdez, Carlos Esteban Villegas‐Mercado

et al.

Cells, Journal Year: 2025, Volume and Issue: 14(8), P. 616 - 616

Published: April 20, 2025

Vasculogenic mimicry (VM) has recently been discovered as an alternative mechanism for nourishing cancer cells in vivo. During VM, tumor align and organize themselves into three-dimensional (3D) channel-like structures to transport nutrients oxygen the internal layers of tumors. This mainly occurs aggressive solid tumors associated with poor prognosis oncologic patients. Long non-coding RNAs (lncRNAs) are essential regulators protein-encoding genes involved development progression. These single-stranded RNA molecules regulate critical cellular functions including cell proliferation, apoptosis, angiogenesis, therapy response, migration, invasion, metastasis. Recently, high-throughput RNA-sequencing technologies have identified thousands lncRNAs, but only a small percentage them functionally characterized human cancers. The vast amount data about its genomic expression can allow us dissect their biology make suitable biomarkers diagnosis prognosis. In this study, we reviewed current knowledge role lncRNAs regulating VM cancer. We also examined molecular mechanisms highlight several commonalities between diverse types. Future directions research focused on deciphering function delineated. Finally, potential selected novel therapeutic targets RNA-based interventions is discussed.

Language: Английский

Citations

0