The heterogeneity of NOTCH1 to tumor immune infiltration in pan-cancer DOI Creative Commons
Xiaojun Duan, Rihan Wu, Mingyang Zhang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 14, 2024

NOTCH1 signaling, a vital regulator of cell proliferation and differentiation, is widely involved in the occurrence development malignant tumors. Pharmacological regulation promising tumor immunotherapy, whereas effective rate existing therapies remains low. functions, as cancer suppressor or promoter different cancers, engaged crosstalk between immune microenvironment cells, posing major challenge to immunotherapy. Therefore, comprehensive view overall situation NOTCH1-associated infiltration pan-cancer should be built. The relation was initially investigated this paper. In study, data originated from Genotype-Tissue Expression (GTEx) Cancer Genome Atlas (TCGA) databases were input into multiple online bioinformatic tools study characteristics pan-cancer. We found that there obvious heterogeneity accordance with heterogeneity, mainly fell two categories, i.e., cancers promoted (termed hot tumors) inhibited cold tumors). further analyzed changes pan-carcinoma species perspectives expression, mutation, gene function, metastasis drugs. expression significantly up-regulated tumors but down-regulated Gene ontology (GO) enrichment analysis categories placed stress on angiogenesis protein dealkylation, respectively. Further, sets facilitated infiltration, dealkylation hindered infiltration. tsRNA associated type angiogenin potentially exerts significant influence angiogenesis. have conducted meticulous function tsRNA. conducive cancer-associated fibroblasts (CAFs) while metastatic process more dependent differentiation NOTCH1. Accordingly, extensively based which can contribute formulation specific immunotherapy strategies.

Language: Английский

The heterogeneity of NOTCH1 to tumor immune infiltration in pan-cancer DOI Creative Commons
Xiaojun Duan, Rihan Wu, Mingyang Zhang

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 14, 2024

NOTCH1 signaling, a vital regulator of cell proliferation and differentiation, is widely involved in the occurrence development malignant tumors. Pharmacological regulation promising tumor immunotherapy, whereas effective rate existing therapies remains low. functions, as cancer suppressor or promoter different cancers, engaged crosstalk between immune microenvironment cells, posing major challenge to immunotherapy. Therefore, comprehensive view overall situation NOTCH1-associated infiltration pan-cancer should be built. The relation was initially investigated this paper. In study, data originated from Genotype-Tissue Expression (GTEx) Cancer Genome Atlas (TCGA) databases were input into multiple online bioinformatic tools study characteristics pan-cancer. We found that there obvious heterogeneity accordance with heterogeneity, mainly fell two categories, i.e., cancers promoted (termed hot tumors) inhibited cold tumors). further analyzed changes pan-carcinoma species perspectives expression, mutation, gene function, metastasis drugs. expression significantly up-regulated tumors but down-regulated Gene ontology (GO) enrichment analysis categories placed stress on angiogenesis protein dealkylation, respectively. Further, sets facilitated infiltration, dealkylation hindered infiltration. tsRNA associated type angiogenin potentially exerts significant influence angiogenesis. have conducted meticulous function tsRNA. conducive cancer-associated fibroblasts (CAFs) while metastatic process more dependent differentiation NOTCH1. Accordingly, extensively based which can contribute formulation specific immunotherapy strategies.

Language: Английский

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