Connecting concentrations of copper, selenium, and zinc with transcriptomic and proteomic data of well-characterized human colorectal cancer cell lines DOI Creative Commons
C. Meyer,

Natalia Vukelic,

John M. Mariadason

et al.

Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: unknown, P. 127638 - 127638

Published: March 1, 2025

Colorectal cancer (CRC) incidence is associated with lower circulating selenium and zinc elevated copper concentrations. Moreover, accumulate within tumor tissue, indicating a disturbed homeostasis of these essential trace elements in CRC. This study aimed to identify associations between CRC characteristics (based on genomic, transcriptomic proteomic data) element The concentrations copper, selenium, were measured 83 human cell lines correlated transcript protein expression levels element-related gene signatures. By using publicly available data from Cancer Genome Atlas we investigated the association those signatures survival probability patients. differed their (fold change 7.3), 6), 2.6) not genetic or cellular characteristics, except for KRAS mutant cells. Expression known copper- zinc-related proteins significantly respective concentrations, serving as proxy tumors, patient survival. was case selenoproteins. In addition, an unbiased approach identified novel high low patient's outcome. Herein intracellular lines. Extrapolating primary colorectal tumors revealed that they can inform outcome

Language: Английский

Connecting concentrations of copper, selenium, and zinc with transcriptomic and proteomic data of well-characterized human colorectal cancer cell lines DOI Creative Commons
C. Meyer,

Natalia Vukelic,

John M. Mariadason

et al.

Journal of Trace Elements in Medicine and Biology, Journal Year: 2025, Volume and Issue: unknown, P. 127638 - 127638

Published: March 1, 2025

Colorectal cancer (CRC) incidence is associated with lower circulating selenium and zinc elevated copper concentrations. Moreover, accumulate within tumor tissue, indicating a disturbed homeostasis of these essential trace elements in CRC. This study aimed to identify associations between CRC characteristics (based on genomic, transcriptomic proteomic data) element The concentrations copper, selenium, were measured 83 human cell lines correlated transcript protein expression levels element-related gene signatures. By using publicly available data from Cancer Genome Atlas we investigated the association those signatures survival probability patients. differed their (fold change 7.3), 6), 2.6) not genetic or cellular characteristics, except for KRAS mutant cells. Expression known copper- zinc-related proteins significantly respective concentrations, serving as proxy tumors, patient survival. was case selenoproteins. In addition, an unbiased approach identified novel high low patient's outcome. Herein intracellular lines. Extrapolating primary colorectal tumors revealed that they can inform outcome

Language: Английский

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