Toward individualized connectomes of brain morphology

Trends in Neurosciences, Journal Year: 2023, Volume and Issue: 47(2), P. 106 - 119

Published: Dec. 22, 2023

Language: Английский

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Alterations in individual structural covariance networks in patients with insomnia disorder

Brain-Apparatus Communication A Journal of Bacomics, Journal Year: 2025, Volume and Issue: 4(1)

Published: Feb. 27, 2025

Language: Английский

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Disrupted topological organization of brain connectome in patients with chronic low back related leg pain and clinical correlations

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 4, 2025

Abstract Chronic pain is associated with persistent alterations in brain structure and function. However, existing research has not fully explored the relationship between network topological properties clinical symptoms patients chronic low back-related leg (cLBLP). In this study, we collected resting-state functional structural magnetic resonance imaging data, along symptom evaluation from 32 cLBLP 31 healthy controls. A large-scale complex analysis was conducted to evaluate global nodal of networks. Statistical analyses were performed determine associations variables. The results showed significant both networks compared Additionally, a direct correlation found spatial discrimination ability, measured by two-point tactile values, while no association observed connectivity discrimination. This study demonstrates that exbibit decreased local efficiency increased compensatory network. Notably, connectome, rather than play more role deterioration foot acuity patients. Trial registration : trial registered Chinese Clinical Registry number ChiCTR2200055321 on 2022-01-06.

Language: Английский

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Alterations in cortical thickness of frontoparietal regions in patients with social anxiety disorder

Psychiatry Research Neuroimaging, Journal Year: 2024, Volume and Issue: 340, P. 111804 - 111804

Published: Feb. 27, 2024

Although functional changes of the frontal and (para)limbic area for emotional hyper-reactivity dysregulation are well documented in social anxiety disorder (SAD), prior studies on structural have shown mixed results. This study aimed to identify differences cortical thickness between SAD healthy controls (CON). Thirty-five patients with forty-two matched CON underwent magnetic resonance imaging. A vertex-based whole brain regional analyses were conducted between-group comparison. The whole-brain analysis revealed increased left insula, superior parietal lobule, temporal gyrus, frontopolar cortex compared CON, as decreased superior/middle gyrus fusiform (after multiple-correction). results from ROI did not align these findings at statistically significant level after multiple corrections. Changes correlated symptoms. While consistent obtained different methods, suggest that exhibit distinct neural deficits areas involved salience, attention, socioemotional processing.

Language: Английский

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Abnormal large‐scale brain functional network dynamics in social anxiety disorder

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(8)

Published: Aug. 1, 2024

Abstract Aims Although static abnormalities of functional brain networks have been observed in patients with social anxiety disorder (SAD), the connectome dynamics at macroscale network level remain obscure. We therefore used a multivariate data‐driven method to search for dynamic connectivity (dFNC) alterations SAD. Methods conducted spatial independent component analysis, and sliding‐window approach k‐means clustering algorithm, characterize recurring states resting‐state networks; then state transition metrics FNC strength different were compared between SAD healthy controls (HC), relationship clinical characteristics was explored. Results Four distinct identified. Compared HC, demonstrated higher fractional windows mean dwelling time highest‐frequency State 3, representing “widely weaker” FNC, but lower States 2 4, “locally stronger” respectively. In 1, moderate” showed decreased mainly default mode attention perceptual networks. Some aberrant dFNC signatures correlated illness duration. Conclusion These patterns synchronization among large‐scale may provide new insights into neuro‐functional underpinnings

Language: Английский

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Abnormal topological structure of structural covariance networks based on fractal dimension in noise induced hearing loss

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 28, 2024

The topological attributes of structural covariance networks (SCNs) based on fractal dimension (FD) and changes in brain network connectivity were investigated using graph theory network-based statistics (NBS) patients with noise-induced hearing loss (NIHL). High-resolution 3D T1 images 40 NIHL 38 healthy controls (HCs) analyzed. FD-based Pearson correlation coefficients calculated converted to Fisher's Z construct the SCNs. Topological hubs theory. measures between groups compared nonparametric permutation tests. Abnormal connection identified NBS analysis. group showed a significantly increased normalized clustering coefficient, characteristic path length, decreased nodal efficiency right medial orbitofrontal gyrus. Additionally, betweenness centrality degree both transverse temporal gyrus left parahippocampal group. analysis revealed two subnetworks abnormal connections. subnetwork enhanced connections was mainly distributed default mode, frontoparietal, dorsal attention, somatomotor networks, whereas reduced limbic, visual, auditory networks. These findings demonstrate structure SCNs NIHL, which may contribute understand complex mechanisms damage at level, providing new theoretical basis for neuropathological mechanisms.

Language: Английский

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Disrupted gray matter connectome in vestibular migraine: a combined machine learning and individual-level morphological brain network analysis

The Journal of Headache and Pain, Journal Year: 2024, Volume and Issue: 25(1)

Published: Oct. 10, 2024

Although gray matter (GM) volume alterations have been extensively documented in previous voxel-based morphometry studies on vestibular migraine (VM), little is known about the impact of this disease topological organization GM morphological networks. This study investigated altered network patterns connectome patients with VM.

Language: Английский

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Neuroanatomical Correlates of Anxiety Disorders and Their Implications in Manifestations of Cognitive and Behavioral Symptoms

Psych, Journal Year: 2023, Volume and Issue: 6(1), P. 34 - 44

Published: Dec. 28, 2023

Developing an anxiety disorder can be the source of further cognitive, behavioral, and emotional struggles, impacting quality life people experiencing such disorders leading to a burden on health systems. Increased knowledge neurobiological events development crucial for diagnostic procedures, as well selection adaptation therapeutic preventive measures. Despite recent advances in this field, research is still at initial steps when it comes understanding specific neurofunctional processes guiding these changes brains with disorder. This narrative review gathered from previous studies, aim evaluating neuroanatomical observed individuals social or generalized (SAD, GAD), link anxiety-related structural modifications brain function abnormalities expression symptoms disorders. In addition, contradictory results are discussed, suggestions future studies.

Language: Английский

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