Genetic Modifiers of Prenatal Brain Injury After Zika Virus Infection: A Scoping Review
medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 2, 2025
Abstract
Introduction
The
severity
of
virally
induced
prenatal
brain
injury,
even
among
dizygotic
twins,
varies
according
to
individual
and
maternal
risk
protective
factors,
including
genomics.
Objective
This
scoping
review
aims
analyze
data
on
genetic
susceptibility
neurological
outcomes
in
children
exposed
utero
Zika
virus.
Methods
We
followed
JBI
methodology
for
this
review.
A
search
PubMed,
Scopus,
CINAHL,
Web
Science,
Academic
Search
Ultimate,
Agricola,
Health
Source:
Nursing/Academic
Edition,
Psychology
Behavioral
Sciences
Collection
was
conducted.
Three
reviewers
independently
screened
studies
using
the
Rayyan
platform.
Studies
gene
mutations
impacting
injury
after
virus
infection
were
included.
Results
Thirteen
articles
identifying
candidate
genes
related
reviewed.
Twenty-three
implicated
modulating
six
17
infant
genes.
Conclusion
Maternal
fetal
factors
likely
contribute
injury.
Analyzing
polygenic
could
aid
future
screening
programs
identify
individuals
at
risk.
information
may
eventually
be
integrated
into
clinical
data,
helping
healthcare
providers,
families,
patients
understand
how
personalize
care
better
outcomes.
Impact
paper
evaluates
available
evidence
about
relationship
between
consequences
exposure
during
pregnancy.
After
performing
a
review,
we
identified
13
describing
that
potentially
development
infection.
Of
identified,
associated
with
risks,
while
linked
fetus.
increase
Future
research
should
investigate
can
modify
disease
pathogenesis
toward
goal
reducing
global
impact
Language: Английский
The microbiome as a modulator of neurological health across the maternal-offspring interface
Journal of Clinical Investigation,
Journal Year:
2025,
Volume and Issue:
135(4)
Published: Feb. 16, 2025
The
maternal
microbiome
is
emerging
as
an
important
factor
that
influences
the
neurological
health
of
mothers
and
their
children.
Recent
studies
highlight
how
microbial
communities
in
gut
can
shape
early-life
development
ways
inform
long-term
trajectories.
Research
on
neurodevelopmental
effects
microbiomes
expanding
our
understanding
microbiome-gut-brain
axis
to
include
signaling
across
maternal-offspring
unit
during
perinatal
period.
In
this
Review,
we
synthesize
existing
literature
modulates
brain
function
behavior
both
developing
offspring.
We
present
evidence
from
human
animal
showing
interacts
with
environmental
factors
impact
risk
for
abnormalities.
further
discuss
molecular
cellular
mechanisms
facilitate
crosstalk
neuromodulation.
Finally,
consider
advancing
these
complex
interactions
could
lead
microbiome-based
interventions
promoting
offspring
health.
Language: Английский
The influence of SARS-CoV-2 spike protein exposure on retinal development in the human retinal organoids
Cell & Bioscience,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: April 11, 2025
Abstract
Background
Pregnant
women
are
considered
a
high-risk
population
for
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
infection,
as
the
virus
can
infect
placenta
and
embryos.
Recently,
SARS-CoV-2
has
been
widely
reported
to
cause
retinal
pathological
changes
embryonic
retina.
The
infection
of
host
cells
by
is
primarily
mediated
through
spike
(S)
protein,
which
also
plays
crucial
role
in
pathogenesis
SARS-CoV-2.
However,
it
remains
poorly
understood
how
S
protein
affects
development,
underlying
mechanism
not
yet
clarified.
Methods
We
used
human
stem
cell-derived
organoids
(hEROs)
model
study
effect
exposure
at
different
stages
development.
hEROs
were
treated
with
μg/mL
on
days
90
280.
Immunofluorescence
staining,
RNA
sequencing,
RT-PCR
performed
assess
influence
development
both
early
late
stages.
Results
results
showed
that
ACE2
TMPRSS2,
receptors
facilitating
entry
into
cells,
expressed
hEROs.
Exposure
induced
an
inflammatory
response
Additionally,
sequencing
indicated
affected
nuclear
components
lipid
metabolism,
while
late-stages
resulted
cell
membrane
extracellular
matrix.
Conclusion
This
work
highlights
differential
effects
stages,
providing
insights
cellular
molecular
mechanisms
SARS-CoV-2-induced
developmental
impairments
Language: Английский
In need of robust evidence of non-association of pregestational and early pregnancy SARS-CoV-2 infections with congenital anomalies
EClinicalMedicine,
Journal Year:
2024,
Volume and Issue:
74, P. 102729 - 102729
Published: July 13, 2024
SARS-CoV-2
infection
during
pregestational
and
early
pregnancy
periods
has
an
unclear
impact
on
fetal
development.
Although
vertical
transmission
is
rare,
potential
effects
the
developing
brain
are
plausible.
However,
robust
evidence
linking
maternal
to
congenital
anomalies
limited
due
inadequate
tracking
of
history
methodological
flaws
in
published
studies.
This
further
complicated
by
limitations,
such
as
restricted
testing
access
undiagnosed
infections,
particularly
low-
middle-income
countries.
Most
data
focus
hospitalized
women
near
term,
lacking
information
first-
second-trimester
infections.
Thus,
accurate
assessment
COVID-19
essential.
It
should
however
be
emphasised
that
we
have
vaccination
against
before
or
not
associated
with
malformations,
ruling
out
any
role
vaccines
these
increased
rates
abnormalities.
viewpoint
discusses
findings
from
surveillance
registries,
highlights
study
offers
research
recommendations
inform
clinical
guidelines
public
health
strategies,
aiming
mitigate
viral
infections
neurodevelopment.
Language: Английский