Single neuron diversity supports area functional specialization along the visual cortical pathways DOI Creative Commons

Michael Feyerabend,

Stefan Pommer,

MS Jimenez-Sosa

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 13, 2024

Abstract Humans and other primates have specialized visual pathways composed of interconnected cortical areas. The input area V1 contains neurons that encode basic features, whereas downstream in the lateral prefrontal cortex (LPFC) acquire tuning for novel complex feature associations. It has been assumed each is repeatable neuronal subtypes, variations synaptic strength connectivity patterns underlie functional specialization. Here we test hypothesis diversity intrinsic make-up single contributes to specialization along pathways. We measured morphological electrophysiological properties areas LPFC marmosets. Excitatory were larger, less excitable, fired broader spikes than neurons. Some inhibitory fast spiking interneurons had longer axons with latencies a more depolarized action potential trough V1. Intrinsic bursting was found subpopulations both excitatory but not latter may favour temporal summation therefore enhanced plasticity relative Our results show within primate system permeates most processing level, neuron.

Language: Английский

Human brain dynamics are shaped by rare long-range connections over and above cortical geometry DOI Creative Commons
Jakub Vohryzek, Yonatan Sanz Perl, Morten L. Kringelbach

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2025, Volume and Issue: 122(1)

Published: Jan. 3, 2025

A fundamental topological principle is that the container always shapes content. In neuroscience, this translates into how brain anatomy dynamics. From neuroanatomy, topology of mammalian can be approximated by local connectivity, accurately described an exponential distance rule (EDR). The compact, folded geometry cortex shaped and geometric harmonic modes reconstruct much functional However, ignores role rare long-range (LR) cortical connections, crucial for improving information processing in brain, but not captured folding geometry. Here, we show superiority combining LR connectivity with EDR (EDR+LR) capturing dynamics (specifically task-evoked activity) compared to representations. Importantly, orchestration carried out a more efficient manifold made up low number EDR+LR modes. Our results importance complexity activity through low-dimensional

Language: Английский

Citations

3
Community modularity structure promotes the evolution of phase clusters and chimeralike states DOI
Dong Yu, Xuening Li, Xueqin Wang

et al.

Physical review. E, Journal Year: 2025, Volume and Issue: 111(3)

Published: March 24, 2025

Community modularity structure is widely observed across various brain scales, reflecting a balance between information processing efficiency and neural wiring metabolic efficiency. Revealing the relationship community function facilitates our further understanding of brain. Here, we construct an adaptive network (ANN) consisting leaky integrate-and-fire neurons with adaptivity governed by spike-time-dependent plasticity rules. The ANN demonstrates diverse dynamic collective behaviors, including traveling waves dominated initial states, phase-cluster formations, chimeralike states. In addition to functional clustering, spontaneously organizes into structures characterized densely interconnected modules sparse interconnections. Neurons within synchronize, while those remain asynchronous, forming By encoding rhythms, segments asynchronous synchronous structural modules, leading These findings provide evidence supporting perspective that emerges from influenced in complex processes.

Language: Английский

Citations

0
Dissecting attention: Rate modulation vs. phase locking DOI
Moein Esghaei, Julio Martinez‐Trujillo, Stefan Treue

et al.

Neuron, Journal Year: 2024, Volume and Issue: 112(14), P. 2263 - 2264

Published: July 1, 2024

Language: Английский

Citations

1
Deciphering the Blueprint of the Fruit Fly’s Brain DOI
S. R. Kulkarni,

Dani S. Bassett

Physics, Journal Year: 2024, Volume and Issue: 17

Published: Sept. 23, 2024

Language: Английский

Citations

0
The circuit mechanisms of working memory: Key roles of the dorsolateral prefrontal cortex DOI
Amy F.T. Arnsten, Julio Martinez‐Trujillo

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Citations

0
Single neuron diversity supports area functional specialization along the visual cortical pathways DOI Creative Commons

Michael Feyerabend,

Stefan Pommer,

MS Jimenez-Sosa

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 13, 2024

Abstract Humans and other primates have specialized visual pathways composed of interconnected cortical areas. The input area V1 contains neurons that encode basic features, whereas downstream in the lateral prefrontal cortex (LPFC) acquire tuning for novel complex feature associations. It has been assumed each is repeatable neuronal subtypes, variations synaptic strength connectivity patterns underlie functional specialization. Here we test hypothesis diversity intrinsic make-up single contributes to specialization along pathways. We measured morphological electrophysiological properties areas LPFC marmosets. Excitatory were larger, less excitable, fired broader spikes than neurons. Some inhibitory fast spiking interneurons had longer axons with latencies a more depolarized action potential trough V1. Intrinsic bursting was found subpopulations both excitatory but not latter may favour temporal summation therefore enhanced plasticity relative Our results show within primate system permeates most processing level, neuron.

Language: Английский

Citations

0