Cortical dynamics in hand/forelimb S1 and M1 evoked by brief photostimulation of the mouse’s hand

Published: Jan. 31, 2025

Spiking activity along synaptic circuits linking primary somatosensory (S1) and motor (M1) areas is fundamental for sensorimotor integration in cortex. Circuits the ascending pathway through mouse hand/forelimb S1 M1 were recently described detail (Yamawaki et al., 2021). Here, we characterize peripherally evoked spiking dynamics these two cortical same system. Brief (5 ms) optogenetic photostimulation of hand generated short (∼25 barrages first (onset latency 15 then (10 ms later). The estimated propagation speed was 20-fold faster from to than M1. Response amplitudes strongly attenuated approximately a third those S1. Responses typically triphasic, with suppression rebound following initial peak. Parvalbumin (PV) inhibitory interneurons involved each phase, accounting three-quarters spikes S1, their selective sufficed evoke both Partial silencing by PV activation during stimulation reduced sensory responses. These results provide quantitative measures hand/forelimb-related transcortical loop; demonstrate prominent mechanistic role neurons phase response; and, support conceptual model which signals reach via high-speed subcortical generate characteristic activity, densely polysynaptic corticocortical similar but delayed profile activity.

Language: Английский

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Cortical dynamics in hand/forelimb S1 and M1 evoked by brief photostimulation of the mouse’s hand

Published: Jan. 31, 2025

Spiking activity along synaptic circuits linking primary somatosensory (S1) and motor (M1) areas is fundamental for sensorimotor integration in cortex. Circuits the ascending pathway through mouse hand/forelimb S1 M1 were recently described detail (Yamawaki et al., 2021). Here, we characterize peripherally evoked spiking dynamics these two cortical same system. Brief (5 ms) optogenetic photostimulation of hand generated short (∼25 barrages first (onset latency 15 then (10 ms later). The estimated propagation speed was 20-fold faster from to than M1. Response amplitudes strongly attenuated approximately a third those S1. Responses typically triphasic, with suppression rebound following initial peak. Parvalbumin (PV) inhibitory interneurons involved each phase, accounting three-quarters spikes S1, their selective sufficed evoke both Partial silencing by PV activation during stimulation reduced sensory responses. These results provide quantitative measures hand/forelimb-related transcortical loop; demonstrate prominent mechanistic role neurons phase response; and, support conceptual model which signals reach via high-speed subcortical generate characteristic activity, densely polysynaptic corticocortical similar but delayed profile activity.

Language: Английский

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Cortical dynamics in hand/forelimb S1 and M1 evoked by brief photostimulation of the mouse’s hand

Published: May 2, 2025

Spiking activity along synaptic circuits linking primary somatosensory (S1) and motor (M1) areas is fundamental for sensorimotor integration in cortex. Circuits the ascending pathway through mouse hand/forelimb S1 M1 were recently described detail (Yamawaki et al., 2021). Here, we characterize peripherally evoked spiking dynamics these two cortical areas. Brief (5 ms) optogenetic photostimulation of hand generated short (∼25 barrages first (onset latency 15 then (10 ms later). The estimated propagation speed was 20-fold faster from to than M1. Amplitudes strongly attenuated. Responses typically triphasic, with suppression rebound following initial peak. Evoked biased middle layers, consistent thalamocortical connectivity, while that upper corticocortical connectivity. Parvalbumin (PV) inhibitory interneurons involved each phase, accounting three quarters spikes S1, their selective sufficed evoke both Partial silencing by PV activation during stimulation reduced sensory responses. Overall, results how propagates transcortical loop, illuminate vivo relate underlying circuit organization this system.

Language: Английский

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Cortical dynamics in hand/forelimb S1 and M1 evoked by brief photostimulation of the mouse’s hand

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Spiking activity along synaptic circuits linking primary somatosensory (S1) and motor (M1) areas is fundamental for sensorimotor integration in cortex. Circuits the ascending pathway through mouse hand/forelimb S1 M1 were recently described detail (Yamawaki et al., 2021). Here, we characterize peripherally evoked spiking dynamics these two cortical same system. Brief (5 ms) optogenetic photostimulation of hand generated short (∼25 barrages first (onset latency 15 then (10 ms later). The estimated propagation speed was 20-fold faster from to than M1. Response amplitudes strongly attenuated approximately a third those S1. Responses typically triphasic, with suppression rebound following initial peak. Parvalbumin (PV) inhibitory interneurons involved each phase, accounting three-quarters spikes S1, their selective sufficed evoke both Partial silencing by PV activation during stimulation reduced sensory responses. These results provide quantitative measures hand/forelimb-related transcortical loop; demonstrate prominent mechanistic role neurons phase response; and, support conceptual model which signals reach via high-speed subcortical generate characteristic activity, densely polysynaptic corticocortical similar but delayed profile activity.

Language: Английский

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