Individualised quantitative susceptibility mapping reveals abnormal hippocampal iron markers in acute mild traumatic brain injury DOI Creative Commons
C. Essex, Mayan J. Bedggood, Jenna L. Merenstein

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Quantitative susceptibility mapping (QSM) is an advanced post-processing technique of magnetic resonance imaging data that can be leveraged as a surrogate marker iron accumulation in the brain following mild traumatic injury (mTBI). However, subtle tissue content changes characteristic this complex may lost to group-wise averaging when standard statistical models are employed. To provide more clinically- and individually-relevant information, z-tests used build personalised profiles positive abnormal homeostasis. Here, we mapped subject-specific deviations iron-related across 10 bilateral segmentations hippocampal subfields 15 basal nuclei. The healthy normal distribution for each region-of-interest (ROI) was derived from aggregate 25 age-matched male controls ( M = 21.10 years [range: 16-32], SD 4.35) using z-tests. Region-wise z-scores 35 males aged between 16 33 21.60, 4.98) with acute (< 14 days) sports-related mTBI (sr-mTBI) were compared against reference range. Of sr-mTBI participants, 43% exhibited markers at least one ROI, which involved majority (87%) cases. Across all ROIs, particularly dense concentrations observed parasubiculum mammillary nucleus. Injury severity scores not significantly different participants 41.7, 34.5) those without 35.6, 30.8), p 0.5, however, certain nucleus observationally linked clinical symptom phenotype. Taken together, these allude region-of-risk model areas anteromedial head, proximal sphenoid ridge, midline structures vulnerable iron-mediated pathology. These findings underscore importance analyses how sensitive methods map regional dyshomeostasis cranial-dural morphology established biomechanics.

Language: Английский

Individualised quantitative susceptibility mapping reveals abnormal hippocampal iron markers in acute mild traumatic brain injury DOI Creative Commons
C. Essex, Mayan J. Bedggood, Jenna L. Merenstein

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Abstract Quantitative susceptibility mapping (QSM) is an advanced post-processing technique of magnetic resonance imaging data that can be leveraged as a surrogate marker iron accumulation in the brain following mild traumatic injury (mTBI). However, subtle tissue content changes characteristic this complex may lost to group-wise averaging when standard statistical models are employed. To provide more clinically- and individually-relevant information, z-tests used build personalised profiles positive abnormal homeostasis. Here, we mapped subject-specific deviations iron-related across 10 bilateral segmentations hippocampal subfields 15 basal nuclei. The healthy normal distribution for each region-of-interest (ROI) was derived from aggregate 25 age-matched male controls ( M = 21.10 years [range: 16-32], SD 4.35) using z-tests. Region-wise z-scores 35 males aged between 16 33 21.60, 4.98) with acute (< 14 days) sports-related mTBI (sr-mTBI) were compared against reference range. Of sr-mTBI participants, 43% exhibited markers at least one ROI, which involved majority (87%) cases. Across all ROIs, particularly dense concentrations observed parasubiculum mammillary nucleus. Injury severity scores not significantly different participants 41.7, 34.5) those without 35.6, 30.8), p 0.5, however, certain nucleus observationally linked clinical symptom phenotype. Taken together, these allude region-of-risk model areas anteromedial head, proximal sphenoid ridge, midline structures vulnerable iron-mediated pathology. These findings underscore importance analyses how sensitive methods map regional dyshomeostasis cranial-dural morphology established biomechanics.

Language: Английский

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