Multivariate profile and acute-phase correlates of cognitive deficits in a COVID-19 hospitalised cohort

EClinicalMedicine, Journal Year: 2022, Volume and Issue: 47, P. 101417 - 101417

Published: April 28, 2022

Summary

Background

Preliminary evidence has highlighted a possible association between severe COVID-19 and persistent cognitive deficits. Further research is required to confirm this association, determine whether deficits relate clinical features from the acute phase or mental health status at point of assessment, quantify rate recovery.

Methods

46 individuals who received critical care for Addenbrooke's hospital 10th March 2020 31st July (16 mechanically ventilated) underwent detailed computerised assessment alongside scales measuring anxiety, depression post-traumatic stress disorder under supervised conditions mean follow up 6.0 (± 2.1) months following illness. Patient matched control (N = 460) performances were transformed into standard deviation expected scores, accounting age demographic factors using N 66,008 normative datasets. Global accuracy response time composites calculated (G_SScore & G_RT). Linear modelling predicted composite score severity, mental-health admission. The pattern across tasks was qualitatively compared with normal age-related decline, early-stage dementia.

Findings

survivors less accurate (G_SScore=-0.53SDs) slower (G_RT=+0.89SDs) in their responses than controls. Acute illness, but not chronic health, significantly scores (p=​​0.0037) G_RT (p 0.0366)). most prominent task associations higher cognition processing speed, which distinct profiles ageing dementia similar magnitude effects 50 70 years age. A trend towards reduced illness (r∼=0.15) did reach statistical significance.

Interpretation

Cognitive after strongly persist long phase, recover slowly if all, characteristic profile highlighting functions speed.

Funding

This work funded by National Institute Health Research (NIHR) Cambridge Biomedical Centre (BRC), NIHR Clinical Facility (BRC-1215-20014), Charities Trust BioResource RG9402. AH UK Dementia Care Technology Imperial College London Centre. ETB DKM are supported Senior Investigator awards. JBR Wellcome (220258) Medical Council (SUAG/051 G101400). VFJN an Academy Sciences/ Foundation Clinician Scientist Fellowship. views expressed those authors necessarily NHS, Department Social Care.

Language: Английский

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SARS-CoV-2 in immunocompromised individuals

Immunity, Journal Year: 2022, Volume and Issue: 55(10), P. 1779 - 1798

Published: Sept. 13, 2022

Language: Английский

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Determinants of persistence of symptoms and impact on physical and mental wellbeing in Long COVID: A prospective cohort study

Journal of Infection, Journal Year: 2022, Volume and Issue: 84(4), P. 566 - 572

Published: Feb. 10, 2022

Residual symptoms can be detected for several months after COVID-19. To better understand the predictors and impact of symptom persistence we analyzed a prospective cohort COVID-19 patients.Patients were followed 9 onset. Duration symptoms, physical health psychological distress assessed.465 patients (54% males, 51% hospitalized) included; 37% presented with at least 4 42% complained lasting more than 28 days. At month 9, 20% still symptomatic, showing mainly fatigue (11%) breathlessness (8%). Hospitalization ICU stay vs. non-hospitalized status increased median duration 8 weeks. Age > 50 years (OR 2.50), 2.35), presentation or 2.04) independent 9. A total 18% did not return to optimal pre-COVID health, while 19% showed Hospital admission 2.28) day 2.21) 5.16) suboptimal female gender 5.27) 2.42) 2.48) risk factors distress.Patients advanced age, multiple onset likely suffer from long-term which had negative on both mental wellbeing. This study contributes identify target populations Long COVID consequences planning recovery interventions.

Language: Английский

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Systematic Review of the Prevalence of Long COVID

Open Forum Infectious Diseases, Journal Year: 2023, Volume and Issue: 10(7)

Published: May 3, 2023

Abstract Background Long COVID occurs in those infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) whose symptoms persist or develop beyond the phase. We conducted a systematic review to determine prevalence of persistent symptoms, functional disability, pathological changes adults children at least 12 weeks postinfection. Methods searched key registers and databases from January 1, 2020 November 2, 2021, limited publications English studies 100 participants. Studies which all participants were critically ill excluded. was extracted as 1 symptom pathology, most common later. Heterogeneity quantified absolute terms proportion total variation explored across predefined subgroups (PROSPERO ID CRD42020218351). Results One hundred twenty 130 included. Length follow-up varied between months. Few had low risk bias. All complete subgroup analyses except I2 ≥90%, range 0%–93% (pooled estimate [PE], 42.1%; 95% prediction interval [PI], 6.8% 87.9%). using routine healthcare records tended report lower (PE, 13.6%; PI, 1.2% 68%) symptoms/pathology than self-report 43.9%; 8.2% 87.2%). However, systematically investigating pathology follow up highest estimates 3 51.7%; 12.3% 89.1%). hospitalized cases generally higher community-based studies. Conclusions The way is defined measured affects estimation. Given widespread nature SARS-CoV-2 infection globally, burden chronic illness likely be substantial even conservative estimates.

Language: Английский

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Clinical patterns of somatic symptoms in patients suffering from post-acute long COVID: a systematic review

European Journal of Clinical Microbiology & Infectious Diseases, Journal Year: 2022, Volume and Issue: 41(4), P. 515 - 545

Published: Feb. 10, 2022

Language: Английский

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