Infection Prevention in Practice,
Journal Year:
2022,
Volume and Issue:
5(1), P. 100261 - 100261
Published: Nov. 29, 2022
No
nosocomial
infection
was
recorded
in
our
healthcare
workers
(HCWs)
during
the
early
phase
of
coronavirus
disease
2019
(COVID-19)
pandemic.
With
emergence
Omicron
variant
increased
transmissibility,
HCWs
occurred
as
expected.
We
aimed
to
study
epidemiology
and
describe
control
measures
outbreak
variant.With
daily
rapid
antigen
testing
molecular
confirmation
test
for
COVID-19,
infected
were
interviewed
by
nurses
(ICNs)
investigate
potential
source
infection.
The
COVID-19
Hong
Kong
served
reference.During
fifth
wave
(31
December
2021
31
May
2022),
1,200,068
cases
reported
(incidence
95
times
higher
than
preceding
waves
Kong;
162,103
vs
1,707
per
million
population
respectively,
P<0.001).
proportion
significantly
that
general
(24.9%,
1,607/6,452
16.2%,
1,200,068/7,403,100
respectively;
P<0.01).
non-clinical
staff
clinical
(31.8%,
536/1,687
22.5%,
1,071/4,765
Of
82.8%
(1,330/1,607)
ICNs,
99.5%
(1,324/1,330)
had
been
fully
vaccinated;
49.5%
(659/1,330)
no
identifiable
source;
40.7%
(541/1,330)
probably
from
household
members;
9.8%
(130/1,330)
possible
exposure
confirmed
patients
or
HCWs,
but
lapse
inappropriate
use
personal
protective
equipment
recalled.Omicron
is
highly
transmissible
such
breakthrough
despite
high
level
vaccination.
Science,
Journal Year:
2022,
Volume and Issue:
376(6600)
Published: May 24, 2022
Rapid
transmission
of
the
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
Omicron
variant
has
led
to
record-breaking
incidence
rates
around
world.
The
Real-time
Assessment
Community
Transmission-1
(REACT-1)
study
tracked
SARS-CoV-2
infection
in
England
using
reverse
transcription
polymerase
chain
reaction
(RT-PCR)
results
from
self-administered
throat
and
nose
swabs
randomly
selected
participants
aged
5
years
older
approximately
monthly
May
2020
March
2022.
Weighted
prevalence
2022
was
highest
recorded
REACT-1
at
6.37%
(
N
=
109,181),
with
BA.2
largely
replacing
BA.1
variant.
Prevalence
increasing
overall,
greatest
increase
those
65
74
75
older.
This
associated
increased
hospitalizations
deaths,
but
much
lower
levels
than
previous
waves
against
a
backdrop
high
vaccination.
Nature Communications,
Journal Year:
2022,
Volume and Issue:
13(1)
Published: June 24, 2022
Abstract
Monitoring
population
protective
immunity
against
SARS-CoV-2
variants
is
critical
for
risk
assessment.
We
hypothesize
that
Hong
Kong’s
explosive
Omicron
BA.2
outbreak
in
early
2022
could
be
explained
by
low
herd
immunity.
Our
seroprevalence
study
using
sera
collected
from
January
to
December
2021
shows
a
very
prevalence
of
neutralizing
antibodies
(NAb)
ancestral
virus
among
older
adults.
The
age
group-specific
NAb
generally
correlates
with
the
vaccination
uptake
rate,
but
adults
have
much
lower
seropositive
rate
than
rate.
For
all
groups,
variant
virus.
suggests
this
and
exceptionally
high
case-fatality
≥80
year-old
group
(9.2%)
attributed
lack
population,
especially
vulnerable
adults,
ongoing
sero-surveillance
essential.
Emerging Microbes & Infections,
Journal Year:
2022,
Volume and Issue:
11(1), P. 1742 - 1750
Published: June 22, 2022
There
has
been
a
rapid
surge
of
hospitalization
due
to
the
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
Omicron
variants
globally.
The
severity
BA.2
in
unexposed,
unvaccinated,
hospitalized
children
is
unknown.
We
investigated
and
clinical
outcomes
COVID-19
infection
during
wave
uninfected,
unvaccinated
comparison
with
influenza
parainfluenza
viral
infections.
This
population-based
study
retrieved
data
from
HK
territory-wide
CDARS
database
hospitalisations
all
public
hospitals
compared
for
BA.2-dominant
fifth
(5-28
February
2022,
n
=
1144),
viruses
(1
January
2015-31
December
2019,
32212
16423,
respectively)
0-11
years
old.
Two
deaths
(0.2%)
out
1144
cases
initial
were
recorded.
Twenty-one
(1.8%)
required
PICU
admission,
relative
risk
was
higher
than
virus
(n
254,
0.8%,
adjusted
RR
2.1,
95%CI
1.3-3.3,
p
0.001).
proportion
neurological
complications
15.0%
171)
Omicron,
which
2707,
8.4%,
1.6,
1.4-1.9
1258,
7.7%,
1.9,
1.6-2.2,
<
0.001
both,
respectively).
Croup
occurred
61,
5.3%)
more
601,
1.9%,
2.0,
1.5-2.6,
0.001)
but
not
889,
5.4%).
Our
findings
showed
that
who
had
no
past
or
vaccination,
mild.
appeared
be
neuropathogenic
viruses.
It
targeted
upper
airways
virus.
Viruses,
Journal Year:
2022,
Volume and Issue:
14(11), P. 2519 - 2519
Published: Nov. 14, 2022
Hong
Kong
SAR
has
adopted
universal
masking,
social
distancing,
testing
of
all
symptomatic
and
high-risk
groups
for
isolation
confirmed
cases
in
healthcare
facilities,
quarantine
contacts
as
epidemiological
control
measures
without
city
lockdown
or
border
closure.
These
successfully
suppressed
the
community
transmission
pre-Omicron
SARS-CoV-2
variants
lineages
during
first
to
fourth
wave.
No
nosocomial
infection
was
documented
among
workers
300
days.
The
strategy
COVID-19
containment
provide
additional
time
achieve
population
immunity
by
vaccination.
near-zero
situation
about
8
months
2021
did
not
enable
adequate
immunization
eligible
population.
A
combination
factors
identified,
especially
complacency
associated
with
low
local
activity,
together
vaccine
hesitancy.
importation
highly
transmissible
Omicron
variant
kickstarted
fifth
wave
COVID-19,
which
could
no
longer
be
controlled
our
initial
measures.
explosive
wave,
partially
contributed
vertical
airborne
high-rise
residential
buildings,
resulted
over
one
million
infection.
In
this
review,
we
summarize
epidemiology
public
health
against
dissemination
until
day
1000.
Frontiers in Pharmacology,
Journal Year:
2022,
Volume and Issue:
13
Published: June 15, 2022
Background:
The
rapid
worldwide
spread
of
the
Omicron
variant
SARS-CoV-2
has
unleashed
a
new
wave
COVID-19
outbreaks.
efficacy
molnupiravir,
an
approved
drug,
is
still
unknown
in
patients
infected
with
variant.
Objective:
Evaluated
antiviral
and
safety
molnupiravir
variant,
symptom
duration
within
5
days.
Methods:
We
conducted
randomized,
controlled
trial
involving
mild
or
moderate
COVID-19.
Patients
were
randomized
to
orally
receive
(800
mg)
plus
basic
treatment
only
for
days
(BID).
drug
was
evaluated
using
reverse
transcriptase
polymerase
chain
reaction.
Results:
Results
showed
that
time
viral
RNA
clearance
(primary
endpoint)
significantly
decreased
group
(median,
9
days)
compared
control
10
(Log-Rank
p
=
0.0092).
Of
receiving
18.42%
achieved
on
day
treatment,
(0%)
(p
On
7,
40.79%,
6.45%
groups,
respectively,
0.0004).
In
addition,
good
profile,
no
serious
adverse
events
reported.
Conclusion:
Molnupiravir
accelerated
Clinical
Trial
Registration:
[chictr.org.cn],
identifier
[ChiCTR2200056817].
MedComm,
Journal Year:
2023,
Volume and Issue:
4(4)
Published: July 10, 2023
Abstract
Since
the
development
of
Sanger
sequencing
in
1977,
technology
has
played
a
pivotal
role
molecular
biology
research
by
enabling
interpretation
biological
genetic
codes.
Today,
nanopore
is
one
leading
third‐generation
technologies.
With
its
long
reads,
portability,
and
low
cost,
widely
used
various
scientific
fields
including
epidemic
prevention
control,
disease
diagnosis,
animal
plant
breeding.
Despite
initial
concerns
about
high
error
rates,
continuous
innovation
platforms
algorithm
analysis
effectively
addressed
accuracy.
During
coronavirus
(COVID‐19)
pandemic,
critical
detecting
severe
acute
respiratory
syndrome
coronavirus‐2
virus
genome
containing
pandemic.
However,
lack
understanding
this
may
limit
popularization
application.
Nanopore
poised
to
become
mainstream
choice
for
preventing
controlling
COVID‐19
future
epidemics
while
creating
value
other
such
as
oncology
botany.
This
work
introduces
contributions
during
pandemic
promote
public
use
emerging
outbreaks
worldwide.
We
discuss
application
microbial
detection,
cancer
genomes,
genomes
summarize
strategies
improve
