The Influence of the Seasonal Variability of Candida spp. Bloodstream Infections and Antifungal Treatment: A Mediterranean Pilot Study DOI Creative Commons
Paola Di Carlo, Nicola Serra,

Ornella Collotta

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(5), P. 452 - 452

Published: April 29, 2025

Background/Objectives: Various factors associated with seasonality, including temperature, humidity, geographical composition, and seasonal fluctuations, can influence the trends of microbes responsible for hospital infections, such as Candida spp. This study evaluates variability bloodstream infections antifungal resistance in hospitalized patients Sicily. Methods: We retrospectively analyzed demographic epidemiological characteristics 175 blood cultures positive Who were at University Hospital Paolo Giaccone (A.U.O.P.), Palermo, Italy, from 1 January 2022 to 31 December 2024. Data on species also collected hospital’s database system prevent control A.U.O.P. Results: A total patients, 57.7% males, a mean age 68.3 years, included this study. parapsilosis, albicans, glabrata more frequent ICU (54.5%, p = 0.0001), medical (72.5%, 0.0003), surgical settings (24%, 0.0161), respectively. C. parapsilosis was dead (53.2%, 0.005). Among seasons, we observed significantly higher presence Autumn (20%, 0.0436). From analysis albicans each season, except Spring, where most isolates (5.1%, 0.0237) (9.7%, < 0.0001). The fluconazole all seasons. Conclusions: Our highlights resistance, emphasizing climate change’s challenges fungal diseases. These findings may contribute improving prevention treatment strategies candidemia.

Language: Английский

Antifungal Natural Products Originating from Endophytic and Rhizospheric Microbes Isolated from Coastal Vegetation DOI Creative Commons
Sumali Lakmini Dissanayake Jayaweera, Thi Thu Hao Van, Daniel A. Dias

et al.

Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(1), P. 32 - 32

Published: Feb. 17, 2025

Candida infections severely impact patients who are immunocompromised. Currently, there limited options to treat fungal infections, especially drug-resistant-fungal infections. Therefore, investigating alternative or repurposed antifungals is paramount. Endophytic microbes (EMs) and rhizospheric (RMs) emerge as promising reservoirs of bioactive natural compounds. Interestingly, plants that have adapted various environmental conditions harbour a plethora producing variety products can be assessed for potential antifungal activity. To date, EMs RMs residing in coastal their associated not been extensively studied reviewed. this comprehensive review will focus on products, extracted from coastal-vegetation-associated microbiota draw the attention research field. A literature search was conducted by examining both Scopus Google Scholar databases during period 2013–2024 related following vegetation: mangroves, sand dune plants, salt marsh seagrasses. 65 novel compounds derived coastal-plant identified. Mangroves were found most prominent host harbouring antifungal-producing compared with other plants. Coastal-plant-associated partners producers bacterial counterparts. Fifty-four fungal-EM/RM reported demonstrate activities against plant pathogenic fungi well human pathogens. Most bacterial-derived (11 antifungals) previously activity albicans.

Language: Английский

Citations

0
The Influence of the Seasonal Variability of Candida spp. Bloodstream Infections and Antifungal Treatment: A Mediterranean Pilot Study DOI Creative Commons
Paola Di Carlo, Nicola Serra,

Ornella Collotta

et al.

Antibiotics, Journal Year: 2025, Volume and Issue: 14(5), P. 452 - 452

Published: April 29, 2025

Background/Objectives: Various factors associated with seasonality, including temperature, humidity, geographical composition, and seasonal fluctuations, can influence the trends of microbes responsible for hospital infections, such as Candida spp. This study evaluates variability bloodstream infections antifungal resistance in hospitalized patients Sicily. Methods: We retrospectively analyzed demographic epidemiological characteristics 175 blood cultures positive Who were at University Hospital Paolo Giaccone (A.U.O.P.), Palermo, Italy, from 1 January 2022 to 31 December 2024. Data on species also collected hospital’s database system prevent control A.U.O.P. Results: A total patients, 57.7% males, a mean age 68.3 years, included this study. parapsilosis, albicans, glabrata more frequent ICU (54.5%, p = 0.0001), medical (72.5%, 0.0003), surgical settings (24%, 0.0161), respectively. C. parapsilosis was dead (53.2%, 0.005). Among seasons, we observed significantly higher presence Autumn (20%, 0.0436). From analysis albicans each season, except Spring, where most isolates (5.1%, 0.0237) (9.7%, < 0.0001). The fluconazole all seasons. Conclusions: Our highlights resistance, emphasizing climate change’s challenges fungal diseases. These findings may contribute improving prevention treatment strategies candidemia.

Language: Английский

Citations

0