Antifungal Natural Products Originating from Endophytic and Rhizospheric Microbes Isolated from Coastal Vegetation
Journal of Xenobiotics,
Journal Year:
2025,
Volume and Issue:
15(1), P. 32 - 32
Published: Feb. 17, 2025
Candida
infections
severely
impact
patients
who
are
immunocompromised.
Currently,
there
limited
options
to
treat
fungal
infections,
especially
drug-resistant-fungal
infections.
Therefore,
investigating
alternative
or
repurposed
antifungals
is
paramount.
Endophytic
microbes
(EMs)
and
rhizospheric
(RMs)
emerge
as
promising
reservoirs
of
bioactive
natural
compounds.
Interestingly,
plants
that
have
adapted
various
environmental
conditions
harbour
a
plethora
producing
variety
products
can
be
assessed
for
potential
antifungal
activity.
To
date,
EMs
RMs
residing
in
coastal
their
associated
not
been
extensively
studied
reviewed.
this
comprehensive
review
will
focus
on
products,
extracted
from
coastal-vegetation-associated
microbiota
draw
the
attention
research
field.
A
literature
search
was
conducted
by
examining
both
Scopus
Google
Scholar
databases
during
period
2013–2024
related
following
vegetation:
mangroves,
sand
dune
plants,
salt
marsh
seagrasses.
65
novel
compounds
derived
coastal-plant
identified.
Mangroves
were
found
most
prominent
host
harbouring
antifungal-producing
compared
with
other
plants.
Coastal-plant-associated
partners
producers
bacterial
counterparts.
Fifty-four
fungal-EM/RM
reported
demonstrate
activities
against
plant
pathogenic
fungi
well
human
pathogens.
Most
bacterial-derived
(11
antifungals)
previously
activity
albicans.
Language: Английский
The Influence of the Seasonal Variability of Candida spp. Bloodstream Infections and Antifungal Treatment: A Mediterranean Pilot Study
Paola Di Carlo,
No information about this author
Nicola Serra,
No information about this author
Ornella Collotta
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et al.
Antibiotics,
Journal Year:
2025,
Volume and Issue:
14(5), P. 452 - 452
Published: April 29, 2025
Background/Objectives:
Various
factors
associated
with
seasonality,
including
temperature,
humidity,
geographical
composition,
and
seasonal
fluctuations,
can
influence
the
trends
of
microbes
responsible
for
hospital
infections,
such
as
Candida
spp.
This
study
evaluates
variability
bloodstream
infections
antifungal
resistance
in
hospitalized
patients
Sicily.
Methods:
We
retrospectively
analyzed
demographic
epidemiological
characteristics
175
blood
cultures
positive
Who
were
at
University
Hospital
Paolo
Giaccone
(A.U.O.P.),
Palermo,
Italy,
from
1
January
2022
to
31
December
2024.
Data
on
species
also
collected
hospital’s
database
system
prevent
control
A.U.O.P.
Results:
A
total
patients,
57.7%
males,
a
mean
age
68.3
years,
included
this
study.
parapsilosis,
albicans,
glabrata
more
frequent
ICU
(54.5%,
p
=
0.0001),
medical
(72.5%,
0.0003),
surgical
settings
(24%,
0.0161),
respectively.
C.
parapsilosis
was
dead
(53.2%,
0.005).
Among
seasons,
we
observed
significantly
higher
presence
Autumn
(20%,
0.0436).
From
analysis
albicans
each
season,
except
Spring,
where
most
isolates
(5.1%,
0.0237)
(9.7%,
<
0.0001).
The
fluconazole
all
seasons.
Conclusions:
Our
highlights
resistance,
emphasizing
climate
change’s
challenges
fungal
diseases.
These
findings
may
contribute
improving
prevention
treatment
strategies
candidemia.
Language: Английский