Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 207, P. 115216 - 115216
Published: Feb. 21, 2024
Language: Английский
European Heart Journal, Journal Year: 2024, Volume and Issue: 45(36), P. 3415 - 3537
Published: Aug. 30, 2024
Language: Английский
Citations
570
Biomedicines, Journal Year: 2021, Volume and Issue: 9(7), P. 781 - 781
Published: July 6, 2021
Maintenance of endothelial cell integrity is an important component human health and disease since the endothelium can perform various functions including regulation vascular tone, control hemostasis thrombosis, cellular adhesion, smooth muscle proliferation, inflammation. Endothelial dysfunction encompassed by complex pathophysiology that based on nitric oxide synthase uncoupling activation following stimulation from inflammatory mediators (molecular patterns, oxidized lipoproteins, cytokines). The downstream signaling via nuclear factor-κB leads to overexpression adhesion molecules, selectins, chemokines facilitate leukocyte rolling, transmigration subendothelial space. Moreover, oscillatory shear stress pro-inflammatory with increased monocyte apoptosis, effect dependent multiple pathways flow-sensitive microRNA regulation. role neutrophil extracellular traps NLRP3 inflammasome as mechanisms contributing has recently been unveiled under further investigation. Consequently, their activation, injured cells release enter a pro-thrombotic state through coagulation pathways, downregulation thrombomodulin, increase in platelet aggregation owing action von-Willebrand factor, ultimately promoting atherosclerosis progression.
Language: Английский
Citations
364
Frontiers in Medicine, Journal Year: 2022, Volume and Issue: 8
Published: Jan. 20, 2022
Endothelium plays a fundamental role in the cardiovascular system, forming an interface between blood and adjacent tissues by regulating vascular tone through synthesis of nitric oxide, prostaglandins other relaxing factors. Endothelial dysfunction is characterized vasoconstriction, cell proliferation shifting toward proinflammatory prothrombic state. In hypertension endothelial may be involved initiation development inflammation, remodeling, atherosclerosis independently associated with increased risk. Different conditions such as impaired shear stress, inflammation oxidative activation renin angiotensin system have been described important pathophysiological mechanisms dysfunction. The release extracellular vesicles neighboring cells wall has emerged regulator function potential antihypertensive properties beneficial effects counteracting mediated organ damage. Furthermore, macrovesicles are emerging innovative therapeutic approach for protection, allowing delivery bioactive molecules, miRNA drugs interacting system. this review we summarize available evidence about implications diseases, focusing on its sequelae, strategies targeting endothelium aim to improve remodeling.
Language: Английский
Citations
241
Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: 21(6), P. 396 - 416
Published: Jan. 3, 2024
Language: Английский
Citations
106
Progress in Retinal and Eye Research, Journal Year: 2022, Volume and Issue: 91, P. 101095 - 101095
Published: June 24, 2022
In the last two decades evidence has gradually accumulated suggesting that eye may be a unique window for cardiovascular risk stratification based on assessment of subclinical damage retinal microvascular structure and function. This can facilitated by non-invasive analysis static vessel diameters dynamic recording flicker light-induced endothelial function-related dilation both arterioles venules. Recent new findings have made biomarkers strong candidates clinical implementation as reliable predictors. Beyond review current state research, article aims to discuss methodological benefits pitfalls identify research gaps future directions. Above all, potential use screening treatment monitoring disease are highlighted. The provides fundamental comprehension imaging explaining anatomical physiological essentials microcirculation leading detailed description approach. allows better understanding underlying pathology associated with prevalence development disease. A body is presented validity predictive value function incidence outcome. Findings in children indicate utility childhood prevention, efficacy exercise interventions highlight sensitivity biomarkers. Finally, coming from availability normative data, solutions diagnostic challenges discussed conceptual steps towards put into perspective.
Language: Английский
Citations
82
Circulation Research, Journal Year: 2023, Volume and Issue: 132(8), P. 970 - 992
Published: April 13, 2023
The endothelium is considered to be the gatekeeper of vessel wall, maintaining and regulating vascular integrity. In patients with chronic kidney disease, protective endothelial cell functions are impaired due proinflammatory, prothrombotic uremic environment caused by decline in function, adding increase cardiovascular complications this vulnerable patient population. review, we discuss functioning healthy conditions contribution dysfunction disease. Further, summarize phenotypic changes disease relation risk We also review mechanisms that underlie consider potential pharmacological interventions can ameliorate health.
Language: Английский
Citations
80
Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: 21(6), P. 379 - 395
Published: Jan. 2, 2024
Language: Английский
Citations
59
MedComm, Journal Year: 2024, Volume and Issue: 5(8)
Published: July 22, 2024
Abstract Cardiovascular disease (CVD) and its complications are a leading cause of death worldwide. Endothelial dysfunction plays crucial role in the initiation progression CVD, serving as pivotal factor pathogenesis cardiovascular, metabolic, other related diseases. The regulation endothelial is influenced by various risk factors intricate signaling pathways, which vary depending on specific context. Despite numerous research efforts aimed at elucidating mechanisms underlying dysfunction, precise molecular pathways involved remain incompletely understood. This review elucidates recent findings pathophysiological including nitric oxide availability, oxidative stress, inflammation‐mediated pathways. We also discuss impact pathological conditions, atherosclerosis, heart failure, diabetes, hypertension, chronic kidney disease, neurodegenerative Furthermore, we summarize traditional novel potential biomarkers well pharmacological nonpharmacological therapeutic strategies for protection treatment CVD complications. Consequently, this to improve understanding emerging approaches reducing developing associated complications, mitigating dysfunction.
Language: Английский
Citations
33
Heliyon, Journal Year: 2025, Volume and Issue: 11(3), P. e41654 - e41654
Published: Jan. 8, 2025
The importance of nanocomposites constantly attains attention because their unique properties all across the fields especially in medical perspectives. study green-synthesized has grown to be extremely fascinating field research. Nanocomposites are more promising than mono-metallic nanoparticles they exhibit synergistic effects. This review encapsulates current development formulation plant-mediated by using several plant species and impact secondary metabolites on biocompatible functioning. Phyto-synthesis produces diverse nanomaterials with biocompatibility, environment-friendliness, vivo actions, characterized varying sizes, shapes, biochemical nature. process is advantageous conventional physical chemical procedures. New studies have been conducted determine biomedical efficacy against various diseases. Unfortunately, there inadequate investigation into green-assisted nanocomposites. Incorporating phytosynthesized therapeutic interventions not only enhances healing processes but also augments host's immune defenses infections. highlights phytosynthesis applications, including antibacterial, antidiabetic, antiviral, antioxidant, antifungal, anti-cancer, other as well toxicity. explores mechanistic action achieve designated tasks. Biogenic for multimodal imaging potential exchange methods materials Well-designed utilized innovative theranostic agents subsequent objective efficiently diagnosing treating a variety human disorders.
Language: Английский
Citations
3
Cardiovascular Research, Journal Year: 2022, Volume and Issue: 119(1), P. 283 - 293
Published: June 16, 2022
Abstract Aims Endothelial function is essential for cardiovascular health, and flow-mediated dilation (FMD) an established technique to measure it. This paper aims assess FMD values in apparently healthy individuals provides reference facilitate wider clinical use. Methods results In 1,579 (aged 18–76), fasted (data from 44 studies, 6 institutions, 22 operators) were normally distributed inversely univariately correlated with age, body mass index, glucose, cholesterol, blood pressure, brachial artery (BA) diameter. Significant multivariate predictors of age (−0.4%/decade), BMI (0.04%/kg/m2), smoking (−0.7%), BA diameter (−0.44%/mm) that together explained 19% the variability independent operator, institution or ultrasound machine. Individuals high tertile (>6.8%) younger, had smaller diameter, lower pressure cholesterol. low- intermediate fatal risk (SCORE), 26% 53% individuals, respectively, low (<5.4%). After adding data 385 patients stable coronary disease (CAD), ROC analysis (c = 0.841, P < 0.001) showed >6.5% excluded CAD (95% sensitivity; 60% specificity) <3.1% 95% specificity, 31% sensitivity). A meta-analysis meta-regression 82 trials (11 countries, n 3,509) using similar methodology despite considerable heterogeneity (I2 0.97) was on average 6.4% (95%CI: 6.2%, 6.7%) no significant differences between countries but a age-dependent decline (−0.3%/decade, R2 0.13). Conclusions We provide age-adapted frame intervals use as biomarker health. As degree vascular endothelial integrates environmental genetic factors classical CV factors, may more comprehensively classify without standard modifiable serve target prevention.
Language: Английский
Citations
70