Elsevier eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 439 - 444
Published: Feb. 22, 2023
Language: Английский
Molecules, Journal Year: 2022, Volume and Issue: 27(17), P. 5730 - 5730
Published: Sept. 5, 2022
Prostate cancer is one of the malignancies that affects men and significantly contributes to increased mortality rates in globally. Patients affected with prostate present either a localized or advanced disease. In this review, we aim provide holistic overview cancer, including diagnosis disease, mutations leading onset progression treatment options. diagnoses include digital rectal examination, prostate-specific antigen analysis, biopsies. Mutations certain genes are linked onset, progression, metastasis cancer. Treatment for encompasses active surveillance, ablative radiotherapy, radical prostatectomy. Men who relapse metastatic receive androgen deprivation therapy (ADT), salvage chemotherapy. Currently, available options more effective when used as combination therapy; however, despite options, remains be incurable. There has been ongoing research on finding identifying other approaches such use traditional medicine, application nanotechnologies, gene combat drug resistance, well reduce adverse effects come current article, summarize involved alternative
Language: Английский
Citations
484
UroPrecision, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 18, 2025
Abstract Testosterone plays a pivotal role in male health throughout the lifespan. Men generally exhibit higher serum testosterone levels than women, influencing critical aspects of physiology. It drives normal sexual differentiation during fetal development, promotes acquisition pubertal traits, and induces development secondary sex characteristics. While naturally decline with age, this decrease varies greatly between individuals, indicating that aging alone does not account for any specific level. The interindividual variability highlights influence both genetic environmental factors on production. Abnormal changes levels, whether excessive or deficient, can have significant implications men's health, contributing to conditions such as hypogonadism, cardiovascular disease, disorders, metabolic disorders. Precision medicine provides personalized treatment options taking into genetic, hormonal, lifestyle improve outcomes. This tailored approach is also relevant dealing broader reproductive issues, ensuring effective individualized care. review focuses testosterone's varied involvement using biomarkers precision breakthroughs inform therapy future research.
Language: Английский
Citations
1
Medical Oncology, Journal Year: 2024, Volume and Issue: 41(2)
Published: Jan. 6, 2024
Language: Английский
Citations
6
Endocrine, Journal Year: 2024, Volume and Issue: 86(2), P. 850 - 859
Published: July 31, 2024
Language: Английский
Citations
5
Frontiers in Neurology, Journal Year: 2022, Volume and Issue: 12
Published: Feb. 9, 2022
Sleep disorders (SDs) represent an important issue in patients with craniopharyngioma (CP). Nearly 70% of these complain sleep-wake cycle alterations and/or excessive diurnal somnolence due to sleep-related breathing disorders, such as obstructive sleep apnea (OSA) central hypersomnia, including secondary narcolepsy. SDs may severely reduce quality life, increase disease-related cardiorespiratory and cardiovascular morbidity, finally play a major role increased long-term mortality reported on CP. A risk factor for is represented by the hypothalamic syndrome, which develop because direct damage tumor itself complications treatments, neurosurgery radiotherapy, typically includes permanent neuroendocrine dysfunctions, morbid obesity, metabolic disorders. Despite increasing attention general population, particular OSA cardio-metabolic diseases daytime somnolence, evaluation still not routinely proposed Hence, are often underdiagnosed undertreated. The aim this paper update current knowledge pathogenesis prevalence CP propose practical algorithms their management clinical practice. Particular paid screening diagnostic tools appropriate characterization SDs, identification factors, potential sparing surgery prevention obesity SDs. Available medicine, lifestyle interventions, drugs, respiratory devices, discussed, well importance optimal hormone replacement interventions. Current limits diagnosis treatment possible future avenues research agenda also considered.
Language: Английский
Citations
17
Current Oncology, Journal Year: 2023, Volume and Issue: 30(6), P. 5769 - 5794
Published: June 13, 2023
Prostate cancer (PC) is the most common type of tumor in men. In early stage disease, it sensitive to androgen deprivation therapy. patients with metastatic castration-sensitive prostate (mHSPC), chemotherapy and second-generation receptor therapy have led increased survival. However, despite advances management mHSPC, castration resistance unavoidable many develop castration-resistant disease (mCRPC). past few decades, immunotherapy has dramatically changed oncology landscape survival rate types cancer. not yet given revolutionary results other tumors. Research into new treatments very important for mCRPC because its poor prognosis. this review, we focus on reasons apparent intrinsic immunotherapy, possibilities overcoming resistance, clinical evidence therapeutic perspectives regarding a look toward future.
Language: Английский
Citations
11
HORMONES, Journal Year: 2025, Volume and Issue: unknown
Published: April 29, 2025
Language: Английский
Citations
0
Published: May 14, 2025
Androgen deficiency syndrome (ADS) is a subsequent condition that arises after endocrine therapy for prostate cancer. It manifests as reduction in testosterone levels accompanied by symptoms such soreness and weakness of low back knees, fatigue, hot flushes, night sweats. This represents an imbalance between the opposing complementary forces yin yang within body. Utilizing yin-yang theory traditional Chinese medicine, this study analyzes dynamic interplay associated with androgen The objective to provide theoretical guidance from medicine addressing restoring “the balance yang." research contributes understanding potential applications managing hormone-related conditions among cancer patients.
Language: Английский
Citations
0
Journal of Clinical Medicine, Journal Year: 2021, Volume and Issue: 10(19), P. 4361 - 4361
Published: Sept. 24, 2021
Prader-Willi syndrome (PWS) is a complex genetic characterized by hyperphagia, intellectual disability, hypotonia and hypothalamic dysfunction. Adults with PWS often have hormone deficiencies, hypogonadism being the most common. Untreated male can aggravate PWS-related health issues including muscle weakness, obesity, osteoporosis, fatigue. Therefore, timely diagnosis treatment of important. In this article, we share our experience its in adult males present review literature. order to report prevalence type hypogonadism, regimen behavioral issues, retrospectively collected data on medical interviews, physical examinations, biochemical measurements testosterone replacement therapy (TRT) 57 Dutch men PWS. Fifty-six (98%) patients had either primary, central or combined hypogonadism. was associated higher body mass index lower hemoglobin concentrations. TRT complicated challenges one third patients. Undertreatment common normal serum levels were achieved only 30% Based cohort data, literature an international expert panel discussion, provide practical algorithm for prevent undertreatment related adverse outcomes.
Language: Английский
Citations
23
Endocrine, Journal Year: 2021, Volume and Issue: 75(2), P. 360 - 376
Published: Oct. 28, 2021
Chronic heart failure (CHF) leads to an excess of urgent ambulatory visits, recurrent hospital admissions, morbidity, and mortality regardless medical non-medical management the disease. This risk may be attributable, at least in part, comorbid conditions influencing development progression CHF. In this perspective, authors examined described most common endocrine disorders observed patients with CHF, particularly individuals reduced ejection fraction, aiming qualify risks, quantify epidemiological burden discuss about potential role treatment. Thyroid dysfunction is commonly sometimes it could consequence certain medications (e.g., amiodarone). Male female hypogonadism also coexist clinical context, contributing deteriorating prognosis these patients. Furthermore, growth hormone deficiency affect adult myocardium predispose Limited recommendation suggests screen CHF patients, but interesting evaluate possible setting, especially when a high suspicion coexists. Data referring long-term safety effectiveness treatments are limited, their impact on several "hard" endpoints (such as admission, all-cause, cardiovascular mortality) still poorly understood.
Language: Английский
Citations
22