Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107776 - 107776
Published: May 1, 2025
Language: Английский
Circulation Research, Journal Year: 2025, Volume and Issue: 136(5), P. 524 - 550
Published: Feb. 27, 2025
Cardiovascular diseases (CVDs) are experiencing a rapid surge and widely recognized as the leading cause of mortality in current aging society. Given multifactorial etiology CVDs, understanding intricate molecular cellular mechanisms is imperative. Over past 2 decades, many scientists have focused on Sirtuins, family nicotinamide adenine dinucleotide–dependent deacylases. Sirtuins highly conserved across species, from yeasts to primates, play crucial role linking diseases. participate nearly all key physiological pathological processes, ranging embryogenic development stress response aging. Abnormal expression activity exist aging-related diseases, while their activation has shown efficacy mitigating these (eg, CVDs). In terms research, this field maintained fast, sustained growth recent years, fundamental studies clinical trials. review, we present comprehensive, up-to-date discussion biological functions roles regulating cardiovascular biology CVDs. Furthermore, highlight latest advancements utilizing Sirtuin-activating compounds dinucleotide boosters potential pharmacological targets for preventing treating The unresolved issues field—from chemicobiological regulation Sirtuin-targeted CVD investigations—are also discussed. This timely review could be critical updated knowledge Sirtuin CVDs facilitating accessibility Sirtuin-targeting interventions.
Language: Английский
Citations
3
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 29, 2025
Introduction Sirtuin 1, a class III histone deacetylase, plays critical role in the pathophysiology of both diabetes mellitus and bone metabolism by promoting osteoblast differentiation inhibiting osteoclast maturation. However, its exact impact on mineral density (BMD) type 2 (T2DM) remains unclear. This study investigates relationship between 1 levels, BMD, newly diagnosed T2DM patients, specifically examining alterations levels those with concomitant osteoporosis or osteopenia. Methods A total 69 patients 82 control subjects normal glucose tolerance (NGT) were enrolled. Serum turnover markers, including osteocalcin (OC), procollagen N-terminal propeptide (P1NP), β-C-terminal telopeptide I collagen (β-CTX), measured using enzyme-linked immunosorbent assay (ELISA). BMD was assessed via dual-energy X-ray absorptiometry (DXA). Comparisons these parameters made NGT groups. Results further categorized into group (DMn) an osteopenia (DMo), differences subgroups analyzed. Risk factors for osteoporosis/osteopenia also evaluated. found to be significantly diminished relative (P < 0.05), no significant lumbar spine OC, 25(OH)D, β-CTX groups > 0.05). Osteoporosis incidence higher compared controls (34.8% vs. 18.3%, P = 0.026). Subgroup analysis revealed that SIRT1 exhibited reduction Logistic regression indicated age, HDL-C, P1NP, independent risk patients. Discussion In conclusion, decreased serum are associated markers may serve as factor potential biomarker diagnosing disorders
Language: Английский
Citations
0
Expert Opinion on Therapeutic Targets, Journal Year: 2025, Volume and Issue: unknown
Published: March 21, 2025
Introduction Sirtuins (SIRTs) are NAD+-dependent deacetylases that mediate post-translational modifications of proteins. Seven members the SIRT family have been identified in mammals. Importantly, SIRTs interact with numerous metabolic and inflammatory pathways. Thus, researchers investigated their role disorders.
Language: Английский
Citations
0
Journal of Internal Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: April 27, 2025
Abstract Cardiometabolic diseases—including Type 2 diabetes and obesity—remain leading causes of global mortality. Recent advancements in metabolomics have facilitated the identification metabolites that are integral to development insulin resistance, a characteristic feature cardiometabolic disease. Key metabolites, such as branched‐chain amino acids (BCAAs), ceramides, glycine, glutamine, emerged valuable biomarkers for early diagnosis, risk stratification, potential therapeutic targets. Elevated BCAAs ceramides strongly associated with resistance diabetes, whereas glycine exhibits an inverse relationship making it promising target. Metabolites involved energy stress, including ketone bodies, lactate, nicotinamide adenine dinucleotide (NAD⁺), regulate sensitivity metabolic health, ketogenic diets NAD⁺ precursor supplementation showing benefits. Additionally, novel biomarker N ‐lactoyl‐phenylalanine further underscores complexity regulation its potential. This review metabolite‐based diagnostics precision medicine, which could enhance efforts prevention, treatment diseases, ultimately improving patient outcomes quality life.
Language: Английский
Citations
0
International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(9), P. 4240 - 4240
Published: April 29, 2025
Bile acids and their corresponding intestinal epithelial receptors, the farnesoid X receptor (FXR), G protein-coupled bile acid (TGR5), play crucial roles in physiological pathological processes of cells. These receptors are involved regulation absorption, signal transduction, cellular proliferation repair, senescence, energy metabolism, modulation gut microbiota. A comprehensive literature search was conducted using PubMed, employing keywords such as acid, receptor, FXR (nr1h4), TGR5 (gpbar1), cells, proliferation, differentiation, microbiota, inflammatory bowel disease (IBD), colorectal cancer (CRC), irritable syndrome (IBS), with a focus on publications available English. This review examines diverse effects signaling pathways metabolism Additionally, it explores interactions between acids, well implications these for host health, particularly relation to prevalent diseases. Finally, highlights importance developing highly specific ligands context metabolic disorders.
Language: Английский
Citations
0
Pharmacological Research, Journal Year: 2025, Volume and Issue: unknown, P. 107776 - 107776
Published: May 1, 2025
Language: Английский
Citations
0