Discovery Immunology, Journal Year: 2024, Volume and Issue: 3(1)
Published: Jan. 1, 2024
Graphical Abstract.
Language: Английский
Diseases, Journal Year: 2024, Volume and Issue: 12(6), P. 118 - 118
Published: June 3, 2024
According to the definition provided by United Nations, “climate change” describes persistent alterations in temperatures and weather trends. These may arise naturally, such as fluctuations solar cycle. Nonetheless, since 19th century, human activities have emerged primary agent for climate change, primarily attributed combustion of fossil fuels coal, oil, gas. Climate change can potentially influence well-being, agricultural production, housing, safety, employment opportunities all individuals. The immune system is an important interface through which global affects health. Extreme heat, events environmental pollutants could impair both innate adaptive responses, promoting inflammation genomic instability, increasing risk autoimmune chronic inflammatory diseases. Moreover, has impact on soil gut microbiome composition, further explain changes health outcomes. This narrative review aims explore disease, focusing specifically its effects microbiota. Understanding how these factors contribute development physical mental illness allow design strategies aimed at reducing negative pollution
Language: Английский
Citations
5
Risk Management and Healthcare Policy, Journal Year: 2025, Volume and Issue: Volume 18, P. 279 - 290
Published: Jan. 1, 2025
The effect of the diurnal temperature range (DTR) on human health in diverse geographic areas and potential confounding factors are not fully understood. Additionally, while a robust association has been reported between cardiomyopathy (CM), evidence impact DTR is relatively limited. Here, we determined whether an exists CM hospitalisations vulnerable populations. admission data (2016-2021) were collected from seven tertiary hospitals Henan.We used GAM combined with distributed lag non-linear model (DLNM) to investigate delayed effects daily for CM.Stratified analysis was performed subgroups according sex, age, season. Attributable fractions (AF) attributable numbers (AN) employed illustrate disease burden DTR. Overall, 5,757 cases identified. admissions exhibited correlation. High (P95: 15.5 °C) low (P05: 3 increased risk, having stronger effect. Males warm seasons significantly more susceptible DTR, affected youth adults than older adults. AF AN 51% 2,936, respectively. Our results revealed significant hospitalisations, providing valuable insights development targeted prevention control measures.
Language: Английский
Citations
0
Trends in Immunology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 1, 2025
Language: Английский
Citations
0
Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12
Published: April 17, 2025
The objective of this study was to examine the effects extreme temperatures on gene signature and pathways airway epithelial cells in mice asthma patients. We investigated temperature exposure at normal (22°C), low (10°C), high (40°C) fluctuation (40°C for 2 h followed by 10°C next h) B6.Sftpc-CreER T2 ;Ai14(RCL-tdT)-D pediatric adult patient's exposed temperatures. observed that Mmp8, Sftpb, Cxcl15 Cd14 were significantly upregulated model. Cma1, Kit, Fdx1, Elf1a, Cdkn2aipnl, Htatsf1, Mfsd13a, Gtf2h5, Tiam2, Trmt10c 40°C cells. Sftpc, Gpr171, Sic34a2, Cox14, Lamp3, Luc7l, Nxnl, Tmub2, Tob1, Cd3e genes group. Pediatric subjects group consistently showed decreased Wfdc21, Cib3, same time increased Tiam2 Cma1 expression, while exhibited higher expression Sftpc Dld expression. Notably, Cttnbp2 Hbb-bs Adult mild, moderate, severe subject Mub2, Luc71, all Our highlights epithelium both These findings suggest modulate epithelium, potentially serving as clinical indicators or biomarkers response climate change.
Language: Английский
Citations
0
Health Science Reports, Journal Year: 2025, Volume and Issue: 8(4)
Published: April 1, 2025
ABSTRACT Background and Aims Human activities have greatly influenced global temperatures, leading to climate change warming. This narrative review aims explore the relationship between immune system, focusing on how environmental stressors can affect regulation, both hyperactivity suppression. Methods A comprehensive search was conducted in PubMed Google Scholar for peer‐reviewed studies published up June 2024. The terms included “climate change,” “human health,” “infection,” “immunity,” “disease.” Inclusion criteria were based relevance, originality, accessibility. Results Exposure elevated temperatures significantly impair system cells, an overproduction of signaling molecules that promote inflammation. Temperature fluctuations been shown influence various aspects adaptive response, including cell mobilization, antigen processing presentation, lymphocyte trafficking activation, functionality B T cells. Notably, some research suggests heat stress negatively impacts differentiation, replication, proportion, resulting decreased immunoglobulin cytokine production, contributing immunosuppression. Additionally, change‐related exposures compromise epithelial barriers skin, lungs, gut, microbial dysbiosis, dysregulation. Furthermore, factors such as temperature variations, humidity, air pollutant levels may exacerbate prevalence infectious diseases, measles HIV, with varying acute, chronic, latent infections, further variability. Conclusion Climate change, particularly increased function, heightened inflammatory responses, Future should focus developing sustainable management strategies enhance health resilience face ongoing climatic changes.
Language: Английский
Citations
0
Discovery Immunology, Journal Year: 2025, Volume and Issue: 4(1)
Published: Jan. 1, 2025
Language: Английский
Citations
0
Science Advances, Journal Year: 2025, Volume and Issue: 11(13)
Published: March 28, 2025
Steroid hormone levels vary greatly among individuals, between sexes, with age, and across health disease. What drives variance in steroid hormones how they individuals over time are not well studied. To address these questions, we measured 17 a sex-balanced cohort of 949 healthy donors aged 20 to 69 years. We investigated associations biological sex, clinical demographic data, genetics, plasma proteomics. were strongly affected by sex high number lifestyle habits. Key observations the broad impact hormonal birth control female relationship smoking male donors. In 10-year follow-up study, identified significant status only These highlight parameters affecting hormones, underlie importance considering potentially gendered behaviors treatment hormone-related diseases.
Language: Английский
Citations
0
BMC Genomics, Journal Year: 2025, Volume and Issue: 26(1)
Published: April 24, 2025
Abstract Background Heat stress has a significant adverse impact on both livestock and poultry production, posing considerable challenge to the artificial breeding of forest musk deer. However, there is lack studies heat deer, so it necessary understand effects temperature humidity index (THI) variation these animals. Results In according local climate characteristics, blood samples were collected during four periods (April, June, July August) for biochemical indicators transcriptome sequencing. The results showed that cortisol corticosterone concentrations increased significantly in (THI = 74.89, P < 0.05). Moreover, Na + concentration exhibited negatively correlated with THI ( r -0.959, Pr 0.041). Blood urea nitrogen (BUN) (G3) was lower than April (G1) June (G2) total antioxidant capacity (T-AOC) decreased 0.05), creatine kinase (CK) higher August. There positive correlation between immunoglobulin G (IgG) 0.999, 0.001) attributable increase TNF-α transcriptomic comparison G1 G3 revealed largest number differentially expressed genes (DEGs) (6410 up-regulated 472 down-regulated). Among them, JAK1 , AP3B1 FKBP15 most immune-related response stress. Trend analysis indicated pathways related immunity protein metabolism particularly impacted by Conclusions Research indicates disrupts normal deer adversely affects their immune system, which attributed exceeding threshold can tolerate. findings this study provide valuable data support scientific captive enhance understanding dynamics ruminants under
Language: Английский
Citations
0
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 7, 2024
Abstract Steroid hormone levels vary greatly among individuals, between the sexes, with age, and across health disease states. Nevertheless, what drives variance in steroid hormones and, globally, how an individual over time are not well-studied. To address this fundamental gap knowledge, we measured of 17 a sex-balanced cohort 949 healthy donors ranging age from 20-69 years. We investigated associations biological sex, clinical demographic data, genetics, proteomics. were strongly affected by sex as hypothesized, but also associated surprisingly high number lifestyle habits. Key our observations was broad impact hormonal birth control female relationship smoking male donors. Using data collected 10-year follow-up cohort, identified significant status only These provide unique comprehensive resource for level individuals highlight parameters that can these levels. Our findings underly importance considering parameters, such potentially gendered behaviors, preventative care treatment hormone-related diseases. One sentence summary Circulating influenced host genetics.
Language: Английский
Citations
0
Discovery Immunology, Journal Year: 2024, Volume and Issue: 3(1)
Published: Jan. 1, 2024
Graphical Abstract.
Language: Английский
Citations
0