Association of Periodontal Disease with Activity of Crohn’s Disease DOI Creative Commons
Miloš Živić, Nebojša Zdravković, Bojan Stojanović

et al.

Medicina, Journal Year: 2023, Volume and Issue: 59(12), P. 2154 - 2154

Published: Dec. 12, 2023

Crohn's disease (CD) is a chronic inflammatory granulomatous that can affect the entire gastrointestinal tract. It characterized by various extraintestinal manifestations (EIMs), of which oral (OMs) are often possible. One possible OMs periodontal (PD), condition supporting tissues teeth. This study aimed to show existence mutual relationship between clinical activity PD and endoscopic CD.

Language: Английский

The oral-gut microbiota axis: a link in cardiometabolic diseases DOI Creative Commons
Qian Xu, Wenting Wang, Yiwen Li

et al.

npj Biofilms and Microbiomes, Journal Year: 2025, Volume and Issue: 11(1)

Published: Jan. 10, 2025

Language: Английский

Citations

2
Bidirectional association between oral diseases caused by plaque and the inflammatory bowel disease: A systematic review and meta-analysis DOI
Yuqing Zhang, Ce Bian, Chaoran Yu

et al.

Japanese Dental Science Review, Journal Year: 2025, Volume and Issue: 61, P. 7 - 21

Published: Feb. 18, 2025

Language: Английский

Citations

1
Oral and Gut Microbiota Dysbiosis Due to Periodontitis: Systemic Implications and Links to Gastrointestinal Cancer: A Narrative Review DOI Creative Commons

Yaman Sulaiman,

Ingrida Marija Pacauskienė,

Renata Šadzevičienė

et al.

Medicina, Journal Year: 2024, Volume and Issue: 60(9), P. 1416 - 1416

Published: Aug. 29, 2024

Periodontitis can disrupt oral and gut microbiota, leading to dysbiosis that affects overall systemic health. Besides the spread of periodontal pathogens by hematogenous route, they also be translocated into gastrointestinal tract, possibly intervening in neoplastic process tract. This manuscript reviews relationship between microbiota due periodontitis, discussing health implications potential links cancer. article highlights significance effect gut, emphasizing importance maintaining prevent diseases. Lastly, it will go through therapeutic innovations such as probiotics analysis tools for disease detection. These findings mark integration management clinical practice lower risk improve patient outcomes.

Language: Английский

Citations

8
Bidirectional associations between periodontitis and inflammatory bowel disease: A systematic review of longitudinal studies with meta‐analysis and trial sequential analysis DOI
Qiuhao Wang,

Shuze Chen,

Jieyu Zhou

et al.

Journal of Periodontal Research, Journal Year: 2024, Volume and Issue: 59(6), P. 1083 - 1094

Published: June 4, 2024

Abstract The bidirectional associations between periodontitis and inflammatory bowel disease (IBD) with temporal directionality remain inconclusive. This study aims to evaluate the IBD through a systematic review meta‐analysis. Five databases (PubMed, Embase, Web of Science, Scopus Cochrane Library) were systematically searched from inception 27 February 2024. Two independent reviewers performed retrieved studies. Longitudinal studies, including cohort nested case–control considered eligible for design. pooled risk ratio (RR) hazard (HR) derived meta‐analysis used assess whether (or IBD) was factor periodontitis). Trial sequential analysis (TSA) reliability results. Four studies ( n = 10 270 912) on in patients two 33 420) included. result suggested that did not increase (pooled RR 1.04, 95% confidence interval [CI]: 0.99–1.09; p .164; I‐squared statistic [ I 2 ] 27%). For subtypes IBD, associated occurrence ulcerative colitis (UC) 1.12, CI: 1.04–1.21; .003; 38%), but Crohn's (CD) 0.98, 0.92–1.04; .475; 0%). Specifically, UC higher among men HR 1.11, 1.01–1.22; .025; 0%) smokers 1.23, 1.07–1.42; .004; than their counterparts without periodontitis. Patients may have developing 1.37, 1.26–1.49; < .001; 18%); however, increased remained uncertain. TSA results confirmed primary findings. Based limited longitudinal evidence, do exhibit an overall, they are at (not CD). On contrary, over time. More high‐quality needed determine effect specific

Language: Английский

Citations

7
Fecal microbiota and metabolites in the pathogenesis and precision medicine for inflammatory bowel disease DOI Creative Commons
Ju Long, Zhimin Suo, Jian Lin

et al.

Precision Clinical Medicine, Journal Year: 2024, Volume and Issue: 7(3)

Published: July 24, 2024

Abstract Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, and its pathogenesis believed to be associated with an imbalance between commensal organisms intestinal immune system. This significantly influenced by microbiota metabolites plays critical role in maintaining mucosal homeostasis. However, disturbances cause dysregulated responses consequently induce inflammation. Recent studies have illustrated roles IBD underscored potential precision diagnosis therapy. work summarises recent progress this field particularly focuses on application diagnosis, prognosis assessment, treatment effectiveness evaluation, therapeutic management IBD.

Language: Английский

Citations

4
Dental problems and oral microbiome alterations in ulcerative colitis DOI Creative Commons
Robert Kucharski, Bartosz Kamil Sobocki, Ewa Stachowska

et al.

Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 5, 2025

Ulcerative colitis is a chronic disease that has not well-established etiology. The role of microbial dysregulation in its pathogenesis been recently highlighted. Overall, microbiome alterations concern the reduction bacterial abundance and diversity, resulting gut imbalance negatively affecting immunological aspects. There link between ulcerative oral microbiome. changes are found at many levels, from gently dysbiotic composition to presence main periodontal microbes. analysis can be part personalized medicine due fact it potential biomarker. Patients with may manifest dental symptoms/problems, such as periodontitis (strongly related red-complex pathogens— Porphyromonas gingivalis , Tannerella forsythia Treponema denticola bacteria belonging other complexes, Fusobacterium nucleatum Aggregatibacter actinomycetecomitans ), caries, ulcerations, leukoplakia, halitosis, others. Notably, DMFT (Decayed, Missing, Filled Teeth) index higher these patients compared healthy subjects. According some data, lichen planus (which an background) also observed patients. It seems deep understanding association microbiome, immunology, manifestations crucial provide complex treatment point view.

Language: Английский

Citations

0
Oral Fusobacterium nucleatum exacerbates ulcerative colitis via the oral-gut axis: mechanisms and therapeutic implications DOI Creative Commons
Zhili Zheng, Wenqin Jin, Weiwei Guo

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: April 7, 2025

Fusobacterium nucleatum (F. nucleatum) is an anaerobic bacterium known for its association with periodontal disease and oral infections. It has been implicated in the development of gastrointestinal diseases such as inflammatory bowel colorectal cancer. Ulcerative colitis (UC), which characterized by chronic inflammation colon, a condition unknown etiology rising incidence rate, significantly affecting quality life patients. The increased intestinal permeability during UC may facilitate adherence or invasion F. into damaged barrier, leading to exacerbated inflammation. This article introduces concept oral-gut axis, reviewing existing literature analyze role pathogenesis exploring potential pathogenic mechanisms. also summarizes latest advances treating patients who have looks forward prospective therapeutic strategies translational prospects within axis. be key player UC, likely due invasiveness periods permeability. paper discusses innovative approaches prevention management nucleatum, paving way more effective treatment UC. review offers new insights complex relationship between microbiome diseases, enhancing our understanding their dynamic interactions. There paucity on approaches, indicating need further clinical research.

Language: Английский

Citations

0
Oral Health and “Modern” Digestive Diseases: Pathophysiologic and Etiologic Factors DOI Creative Commons
Mihaela Rotaru, Ana-Maria Sîngeap, Alin Ciobîcă

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(8), P. 1854 - 1854

Published: Aug. 15, 2024

In the contemporary era of medicine, exploring complexity human body and its intricate interactions has become a central concern for health researchers. The main purpose this article is to summarize current understanding relevant pathophysiological factors such as chronic inflammation, dysbiosis (microbial imbalance), metabolic disorders, well etiological including dietary habits, lifestyle choices, obesity, syndrome, genetic predispositions, emphasize potential avenues upcoming studies their medical significance. Additionally, aims assess impact integrated treatment approaches on patient outcomes, emphasizing need interdisciplinary collaboration between gastroenterologists, dentists, other healthcare professionals develop comprehensive care plans that address both oral digestive issues simultaneously. Among branches with significant general well-being are cavity diseases, which have been subject intensive research in recent decades. context, analysis state knowledge disorders relation “modern” diseases non-alcoholic fatty liver disease (NAFLD), small intestinal bacterial overgrowth (SIBO), inflammatory bowel (IBD), irritable syndrome (IBS) becomes essential deeper interconnections health. temporal overlap or succession, whether preceding following, manifestations should be taken seriously by gastroenterologists dentists facilitate early diagnosis explain patients correlation these two systems. summary, underscores importance relationship health, advocating improve outcomes guide future research.

Language: Английский

Citations

1
Association of Periodontal Disease with Activity of Crohn’s Disease DOI Creative Commons
Miloš Živić, Nebojša Zdravković, Bojan Stojanović

et al.

Medicina, Journal Year: 2023, Volume and Issue: 59(12), P. 2154 - 2154

Published: Dec. 12, 2023

Crohn's disease (CD) is a chronic inflammatory granulomatous that can affect the entire gastrointestinal tract. It characterized by various extraintestinal manifestations (EIMs), of which oral (OMs) are often possible. One possible OMs periodontal (PD), condition supporting tissues teeth. This study aimed to show existence mutual relationship between clinical activity PD and endoscopic CD.

Language: Английский

Citations

3