medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 23, 2024

Background. Appendicular lean mass index (ALMI), a term used to describe appendicular soft tissue measured by dual-energy X-ray absorptiometry (DXA), is major determinant of cardiorespiratory fitness in patients with obesity-related heart failure preserved ejection fraction (HFpEF). Moreover, ALMI can be diagnose sarcopenia and sarcopenic obesity this population. DXA reference standard for assessing body composition, however, segmental single-frequency bioelectrical impedance analysis (SF-BIA) could offer more accessible, portable, cost-effective, radiation-free alternative. To validate SF-BIA composition HFpEF obesity, focus on ALMI. Methods. We analyzed 62 consecutive euvolemic persistent (83.8% female, 60.8± 2.8 years age). both measure fat (AFMI), (FM), fat-free (FFM) kg as % weight, FM index, FFM index. Correlations were assessed using Pearson?s coefficients Bland-Altman plots, while linear regression was performed evaluate proportional bias. Results. Strong, statistically significant correlations found between BIA (r=0.897), AFMI (r=0.864), (r=0.968), FM% (r=0.867), (r=0.954), FFM% (r=0.852), (r=0.97), (r=0.88) (all p<0.001). The demonstrated agreement methods indicated no bias all parameters, except AFMI. Conclusions. Segmental SF-BIA-measured shows strong correlations, appropriate agreements, compared DXA. Considering the central role particularly HFpEF, when not readily available or contraindicated, should considered

Language: Английский