Elevated 12,13-diHOME level in maternal and umbilical cord blood complicated with preeclampsia DOI Creative Commons

Tomohiro Yoshida,

Kohei Kitada,

Kensaku Nakai

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 8, 2024

Background Preeclampsia (PE) is a condition in pregnancy characterized by hypertension and proteinuria, thus leading to severe complications for both mother fetus, including fetal growth restriction (FGR). However, there are still unclear aspects regarding the pathogenesis, prevention, treatments. This study aimed elucidate characteristics of lipid metabolism maternal umbilical cord plasma complicated with PE using liquid chromatography-mass spectrometry (LC-MS). Method The included singleton pregnant women at Osaka Metropolitan University Hospital from March 2023 February 2024. was diagnosed based on new-onset after 20 weeks gestation other symptoms such as proteinuria organ dysfunction. FGR defined ultrasound measurements below -1.5 standard deviation (SD). Plasma samples were collected blood within 24 hours before delivery. Lipid metabolites comprehensively analyzed LC-MS, lipokine 12,13-diHOME, identified elevated comprehensive analysis, quantified. Immunohistochemistry conducted placental assess soluble epoxide hydrolase (sEH) expression. Results involved 31 participants, control group 11 group. A analysis significant increase 12,13-diHOME levels compared Quantification showed plasma, venous arterial ( p = 0.007, 0.008, 0.005). significantly higher concentrations arterial/venous ratio without 0.03). Negative correlations observed between birth weight did not show differences sEH expression groups. Conclusion demonstrated that patients, particularly FGR. Elevated may reflect progression ischemia due pathogenesis. metabolite could serve marker severity preeclampsia, providing new insights into perinatal lipidomics potential role PE.

Language: Английский

The spleen in ischaemic heart disease DOI
Gerd Heusch, Petra Kleinbongard

Nature Reviews Cardiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

Citations

2
The Role of Exercise-Based Cardiac Rehabilitation After Myocardial Infarction on Cholesterol Transfer to HDL DOI Open Access
José Carlos Nicolau, Talia Falcão Dalçóquio, Roberto R. Giraldez

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 419 - 419

Published: Jan. 6, 2025

High-density lipoprotein (HDL) is associated with decreased incidence of cardiovascular events, and its functionality also influences prognosis. Exercise an important tool to improve prognosis in the post-infarction (MI) population, but role exercise on HDL poorly understood. Sixty-two patients acute MI were randomized a supervised program for 12–14 weeks (exercise group—EG) or control group (CG). The main objective study was analyze esterified cholesterol (EC) unesterified (UC) transfer HDL. For total baseline mean rate EC 2.53 ± 0.83 at end follow-up, it 2.74 0.64 (p = 0.03). figures UC were, respectively, 4.08 1.2 4.4 1.06 0.02). difference (follow-up minus baseline) 0.15 0.84 0.27 0.69 0.53); UC, 0.28 1.14 0.35 0.96 0.80), groups. In post-MI patients, did not functionality.

Language: Английский

Citations

1
Ischaemic heart disease: prevention, management, mechanisms, and new therapeutic targets DOI Creative Commons
Filippo Crea

European Heart Journal, Journal Year: 2024, Volume and Issue: 45(9), P. 637 - 641

Published: March 1, 2024

Language: Английский

Citations

0
Elevated 12,13-diHOME level in maternal and umbilical cord blood complicated with preeclampsia DOI Creative Commons

Tomohiro Yoshida,

Kohei Kitada,

Kensaku Nakai

et al.

Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 8, 2024

Background Preeclampsia (PE) is a condition in pregnancy characterized by hypertension and proteinuria, thus leading to severe complications for both mother fetus, including fetal growth restriction (FGR). However, there are still unclear aspects regarding the pathogenesis, prevention, treatments. This study aimed elucidate characteristics of lipid metabolism maternal umbilical cord plasma complicated with PE using liquid chromatography-mass spectrometry (LC-MS). Method The included singleton pregnant women at Osaka Metropolitan University Hospital from March 2023 February 2024. was diagnosed based on new-onset after 20 weeks gestation other symptoms such as proteinuria organ dysfunction. FGR defined ultrasound measurements below -1.5 standard deviation (SD). Plasma samples were collected blood within 24 hours before delivery. Lipid metabolites comprehensively analyzed LC-MS, lipokine 12,13-diHOME, identified elevated comprehensive analysis, quantified. Immunohistochemistry conducted placental assess soluble epoxide hydrolase (sEH) expression. Results involved 31 participants, control group 11 group. A analysis significant increase 12,13-diHOME levels compared Quantification showed plasma, venous arterial ( p = 0.007, 0.008, 0.005). significantly higher concentrations arterial/venous ratio without 0.03). Negative correlations observed between birth weight did not show differences sEH expression groups. Conclusion demonstrated that patients, particularly FGR. Elevated may reflect progression ischemia due pathogenesis. metabolite could serve marker severity preeclampsia, providing new insights into perinatal lipidomics potential role PE.

Language: Английский

Citations

0