European Heart Journal, Journal Year: 2024, Volume and Issue: 45(21), P. 1861 - 1865
Published: June 1, 2024
][4][5][6][7][8][9][10][11] Reported secular trends of AS incidence remain contradictory and lack quantitative Doppler echocardiographic ascertainment.All adult residents in Olmsted County (MN, USA) diagnosed over 20 years (1997-2016) with incident severe (first diagnosis) based on quantitatively defined measures (aortic valve area ≤1 cm 2 , aortic index ≤0.6 /m mean gradient ≥40 mmHg, peak velocity ≥4 m/s, ≤0.25)were counted to define incidence, presentation, treatment, outcome.Incident was 1069 community residents.The rate 52 per 100 000 patient-years, slightly higher males vs. females, almost unchanged after age sex adjustment for the US population, 53 residents/year.Over years, remained stable (P = .2) but absolute burden cases markedly increased .0004)due population growth.Incidence trend differed by sex, being men (incidence ratio 0.99, P .7)but declining women 0.93, .02).Over study period, clinical characteristics remarkably AVR performance grew more prompt, undertreatment prominent (>40%).Early associated survival benefit [adjusted hazard (HR) 0.55, 95% confidence interval (CI) 0.42-0.71,P < .0001].Despite these improvements, overall mortality (3-month 8% 3-year 36%) swift, considerable, unabated (all ≥ .4)throughout study.Benfari et al. conclude that remains case related growth.Despite has grown notably; however, while declining,
Language: Английский