Medicine,
Journal Year:
2025,
Volume and Issue:
104(7), P. e41524 - e41524
Published: Feb. 14, 2025
Chronic
limb-threatening
ischemia
(CLTI)
is
associated
with
significant
mortality
and
limb
loss.
The
interventional
lumbar
sympathectomy
(LS)
one
of
the
supportive
treatment
options
for
CLTI
patients,
reducing
pain
intensity
peripheral
arterial
resistance.
use
LS
has
gradually
declined
despite
its
positive
effects.
contradictory
results
studies
dealing
evidence
tissue
perfusion
improvement
after
are
possible
explanations.
We
describe
a
new
approach
evaluation
efficacy
in
2
patients
below-the-knee
arteries
pathology
our
observational
cohort
experimental
trial.
utilized
angiosome
concept
foot.
Angiography
identified
angiosomes
occluded
source
artery.
relationship
between
corresponding
surface
areas
angiosomes-dermatomes
was
identified.
infrared
thermography
used
measurement
thermal
changes
dermatomes
before
LS.
Based
on
their
dermatomes,
we
estimated
procedure.
found
that
clinically
relevant
increase
temperature
(>1°C)
presented
only
to
hypothesize
opens
up
anastomoses
angiosomes,
resulting
redistribution
blood
flow
an
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(2), P. 493 - 493
Published: Jan. 14, 2025
Background/Objectives:
This
study
assessed
the
proportion
of
secondary
cardiovascular
prevention
patients
who
achieved
low-density
lipoprotein
(LDL)
cholesterol
targets
as
per
2019
ESC/EAS
Dyslipidemia
Guidelines.
We
also
evaluated
whether
lipid-lowering
therapies
(LLTs)
were
adjusted
in
not
meeting
and
analyzed
likelihood
these
modifications
achieving
recommended
levels.
Methods:
A
multicenter,
cross-sectional
observational
retrospectively
reviewed
medical
records
1909
outpatients
9
Italian
cardiac
rehabilitation/secondary
clinics
from
January
2023
to
June
2024.
Inclusion
criteria
included
prior
atherosclerotic
disease
(ASCVD)
recent
LDL-cholesterol
Data
demographics,
ASCVD
presentation,
lipid
profiles,
LLTs.
Patients
at
very
high
risk
had
LDL
≤55
mg/dL,
or
≤40
mg/dL
for
recurrent
events
within
2
years.
Clinicians'
approaches
LLT
modification
target
recorded,
with
efficacy
estimated
based
on
percentage
distance
targets.
Results:
Of
patients,
41.3%
met
target.
Predictors
male
gender,
rehabilitation,
acute
coronary
syndrome,
diabetes,
triple
therapy
(statin
+
ezetimibe
PCSK9
inhibitors).
Conversely,
a
lack
therapy,
monotherapy
negative
predictors.
Among
1074
target,
proposed
48.6%.
events,
greater
while
advanced
age
an
However,
only
42.3%
modified
predicted
be
effective
reaching
Conclusions:
Despite
guidelines,
significant
high-risk
did
achieve
targets,
often
insufficient.
More
intensive
regimens
are
needed
improve
outcomes
this
population.
Journal of Inflammation Research,
Journal Year:
2025,
Volume and Issue:
Volume 18, P. 1303 - 1316
Published: Jan. 1, 2025
This
study
aims
to
develop
and
validate
a
nomogram
based
on
the
Systemic
Inflammatory
Response
Index
(SIRI)
predict
short-term
aortic-related
adverse
events
(ARAEs)
in
patients
with
acute
uncomplicated
Type
B
intramural
hematoma
(IMH).
We
retrospectively
analyzed
332
diagnosed
IMH
between
April
2018
2024.
Patients
were
categorized
into
stable
group
(N=225)
exacerbation
(N=107)
occurrence
of
ARAEs
within
30-day
observation
period.
SIRI
was
calculated
using
neutrophil,
monocyte,
lymphocyte
counts.
defined
as
death
related
aortic
disease,
progression
dissection
or
penetrating
ulcer.
The
developed
incorporating
other
significant
clinical
variables.
model's
performance
evaluated
area
under
curve
(AUC),
calibration
curves,
decision
analysis
(DCA),
net
reclassification
index
(NRI).
Among
patients,
217
male
(65.4%),
mean
age
64.3±9.4
years.
Multivariate
logistic
regression
LASSO
analyses
identified
SIRI,
anemia,
diabetes,
maximum
diameter
(MDAD),
ulcer
like
projection
(ULP)
independent
predictors
ARAEs.
Two
models
developed:
Clinical
model,
including
MDAD,
ULP;
Clinical-SIRI
model.
model
demonstrated
higher
predictive
accuracy,
an
AUC
0.788
(95%
CI:
0.740-0.831),
compared
0.742
0.691-0.788,
P
=
0.012).
improved
shown
by
continuous
NRI
0.521
0.301-0.743).
Calibration
curves
DCA
further
supported
utility
SIRI-based
is
valuable
prognostic
tool
for
predicting
IMH.
Journal of Cardiothoracic Surgery,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Jan. 3, 2025
Pseudoaneurysm
after
coarctation
of
the
aorta
(CoA)
repair
is
a
rare
but
severe
complication.
Contributing
factors
may
include
infection,
hypertension,
aortic
wall
weakness,
and
turbulent
blood
flow
at
site.
A
35-year-old
male
presented
with
recurrent
episodes
epistaxis
dizziness
was
admitted
to
emergency
department.
He
had
history
CoA
ventricular
septal
defect
closure
17
years
ago.
Physical
examination
revealed
elevated
pressure.
Initially,
dissection
suspected,
actual
diagnosis
pseudoaneurysm
just
distal
left
subclavian
artery.
Surgical
intervention
involved
excision
replacement
new
vascular
graft
via
dual
approach
median
sternotomy
thoracotomy.
Postoperative
recovery
uneventful,
follow-up
imaging
one
month
showed
satisfactory
morphology.
This
case
underscores
critical
role
precise
in
differentiating
pseudoaneurysms
from
other
lesions
post-CoA
patients.
Pseudoaneurysms
can
present
subtly
yet
carry
substantial
risks,
making
regular
essential
for
early
detection
improved
outcomes.
Journal of Cardiothoracic Surgery,
Journal Year:
2025,
Volume and Issue:
20(1)
Published: Jan. 8, 2025
Abstract
Objectives
Despite
the
advances
in
medicine,
aortic
dissection
remains
a
cardiac
surgery
emergency
with
high
mortality
and
morbidity
rates.
This
study
examined
effects
of
Glue
+
Felt
technique,
which
uses
biological
glue
felt
to
repair
proximal
anastomotic
site,
on
outcomes
patients
acute
type
A
dissection.
Methods
total
108
who
underwent
for
at
our
clinic
between
2007
2020
were
included
study.
The
divided
into
two
groups:
"Glue
Technique"
"Bentall-De
Bono"
groups,
based
surgical
technique
used
root.
these
techniques
development
intraoperative
postoperative
complications
survival
rates
statistically
analyzed.
Results
was
76
patients,
while
Bentall-De
Bono
32
patients.
Kaplan–Meier
analysis
revealed
significant
differences
groups
over
entire
follow-up
period,
both
without
propensity
score
matching
(
p
<
0.001
=
0.02,
respectively).
However,
no
observed
comparisons
beyond
first
30
days
follow-up,
either
or
0.573
0.561,
main
factors
contributing
this
difference
duration
cardiopulmonary
bypass
cross-clamp
time
0.05).
During
average
period
46.2
±
31.6
months,
re-intervention
required
from
Glue-Felt
group.
Conclusions
rate
is
higher
more
extensive
intervention
as
increases.
Repairing
lumen
reducing
operation
suitable
using
site
positively
impacts
improves
in-hospital
30-day
rates,
increasing
long-term