Rheumatology Science and Practice,
Journal Year:
2024,
Volume and Issue:
62(5), P. 445 - 464
Published: Oct. 31, 2024
The
main
indications
for
colchicine
treatment
until
recently
were
gout,
pericarditis,
familial
Mediterranean
fever
and
some
other
auto-inflammatory
diseases.
expansion
of
(repositioning)
the
use
in
direction
prevention
cardiovascular
complications
should
be
considered
as
one
major
events
medicine
XXI
century.
Deciphering
role
inflammation
most
important
mechanism
development
atherosclerosis
has
created
prerequisites
concept
anti-inflammatory
therapy
atherosclerosis,
which
low-dose
can
take
an
place,
complementing
effects
aspirin,
statins
antihypertensive
therapy.
analysis
materials
from
randomized
placebo-controlled
studies
indicates
a
decrease
frequency
patients
with
coronary
heart
disease
(by
31%)
who
have
suffered
myocardial
infarction
23%),
well
33%),
stroke,
need
revascularization
mortality.
low
dose
(0.5
mg/day)
is
approved
by
U.S.
Food
Drug
Administration
disease.
It
assumed
that
future
will
place
pathology
associated
atherosclerotic
vascular
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(23), P. 4195 - 4195
Published: Dec. 4, 2024
In
this
review,
we
provide
an
evidence-based
approach
to
determine
the
cellular
and
systemic
actions
of
two
structurally
similar
flavonoids,
apigenin
chrysin.
We
have
clearly
evaluated
charted
overlapping
diverging
properties
these
sister
flavonoids.
Based
on
separate
Omics-based
approaches
by
our
group
independent
reports
from
others,
cholesterol-lowering
been
revealed.
addition,
prevention
uric
acid
biosynthesis
enhancement
ketogenesis
also
quite
evident
in
Along
with
functions,
chrysin
demonstrated
unique
that
allow
them
stand
out
each
other.
Chrysin
has
abilities
like
downregulating
alanine
metabolism
pyrimidine
synthesis,
which
could
be
helpful
metabolic
diseases
cancer.
contrast,
anti-oxidant
anti-inflammatory
enhancing
endogenous
lipids
upregulating
vasoprotective
metabolites,
beneficial
for
cardiovascular,
renal,
cerebrovascular
complications.
Further
validation
studies
using
vivo
translational
us
better
clarity
regarding
use
agents
therapeutically
treat
a
combination
or
pool
diseases.
Rheumatology Science and Practice,
Journal Year:
2024,
Volume and Issue:
62(5), P. 445 - 464
Published: Oct. 31, 2024
The
main
indications
for
colchicine
treatment
until
recently
were
gout,
pericarditis,
familial
Mediterranean
fever
and
some
other
auto-inflammatory
diseases.
expansion
of
(repositioning)
the
use
in
direction
prevention
cardiovascular
complications
should
be
considered
as
one
major
events
medicine
XXI
century.
Deciphering
role
inflammation
most
important
mechanism
development
atherosclerosis
has
created
prerequisites
concept
anti-inflammatory
therapy
atherosclerosis,
which
low-dose
can
take
an
place,
complementing
effects
aspirin,
statins
antihypertensive
therapy.
analysis
materials
from
randomized
placebo-controlled
studies
indicates
a
decrease
frequency
patients
with
coronary
heart
disease
(by
31%)
who
have
suffered
myocardial
infarction
23%),
well
33%),
stroke,
need
revascularization
mortality.
low
dose
(0.5
mg/day)
is
approved
by
U.S.
Food
Drug
Administration
disease.
It
assumed
that
future
will
place
pathology
associated
atherosclerotic
vascular
