Aspirin: latest evidence and developments

Heart, Journal Year: 2024, Volume and Issue: 110(17), P. 1069 - 1073

Published: July 29, 2024

Aspirin is a foundation drug of the pharmaceutical industry originally derived as an analgesic/anti-inflammatory agent but serendipitously discovered to have use prophylactic for major adverse cardiovascular events (MACE). Its modern-day utility in this latter role relies on its efficacy/safety balance contemporary population where, at least high-income countries, age-standardised incident rates MACE are falling, and where there now competing therapeutic agents. future may be determined by potential chemoprophylactic or adjunct cancer other disease states. It therefore will continue subject further clinical research.

Language: Английский

---

ASSESSING THE IMPACT OF LOW-DOSE ASPIRIN ON CARDIOVASCULAR DISEASE PREVENTION IN DIABETIC PATIENTS

Published: Jan. 6, 2025

Background: Diabetes significantly increases the risk of cardiovascular disease (CVD), prompting interest in preventive treatments such as low-dose aspirin. Despite its potential, efficacy aspirin this context remains debated. Objective: This study aimed to evaluate effectiveness preventing CVD among individuals with type 2 diabetes. Methods: In double-blind, placebo-controlled, randomized trial, 100 diabetic patients without previous were enrolled. Participants randomly assigned receive either 81 mg/day or a placebo for one year. The primary endpoint was incidence major adverse events (MACE). Results: Each group comprised 50 participants comparable baseline characteristics. MACE 10% compared 28% group, achieving statistical significance (p=0.03). While also showed reductions myocardial infarction and stroke, these differences not statistically significant. Conclusion: Low-dose reduces patients, supporting use intervention high-risk group.

Language: Английский

---

Association between low-dose aspirin and prevalence of chronic obstructive pulmonary disease (COPD): The mediating role of systemic immune inflammation index

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 15, 2025

Background COPD is a respiratory disease with significant inflammatory characteristics. Low-dose aspirin widely used as an anti-inflammatory medicine. However, the impact of low-dose on unclear. This article aims to investigate association between and prevalence COPD. Methods A cohort study was conducted based United States population data from National Health Nutrition Examination Survey (NHANES) (2011–2012, 2013–2014, 2015–2016, 2017–2020, 2021–2023). We examined pairwise associations systemic immune inflammation index (SII), aspirin, by logistic regression analysis, restricted cubic spline (RCS), mediation analyses. Results In 5,668 people, 68% them took aspirin. found higher levels SII in participants compared those without significantly associated (β=-0.015, 95%CI=-0.026, -0.003, p < 0.001) (β = 0.036, 95% CI 0.022, 0.050, ≤ 0.001), even after considering wide range potential confounders (e.g., age, sex, race). nonlinearly mediated marginal portion (PM, -0.039130; ACME -0.000552, [95% -0.001042, 0], 0.01) effects prevalence. Conclusions Our research showed that SII, depression are correlated. may decrease risk COPD, Prophylactic use be advised individuals at high

Language: Английский

---

Population Cessation of Aspirin Use for the Prevention of Cardiovascular Disease

American Journal of Preventive Cardiology, Journal Year: 2025, Volume and Issue: 21, P. 100941 - 100941

Published: Feb. 8, 2025

Aspirin use for primary prevention of cardiovascular diseases (CVD) is widespread with over a third the adult population using despite guidelines recommending against. This population-based research documents rates and reasons cessation from 2015 to 2020, period when changed. Three cross-sectional telephone surveys were conducted during 2015, 2017, 2019-20. A survey in states Iowa, Minnesota, North Dakota, South Wisconsin. The included non-institutionalized resident adults ages 55-79 women 45-79 men landline telephones. analysis 8,197 participants, 4,161 4,036 after excluding those history disease (secondary prevention). was stable first two years (39 % 41 2017) but fell significantly 34 final (2019-2020). most common reason "doctor's advice" (38 quitters) followed by "heard negative news" significant increase 2020 (4 29 quitters). Despite recent findings new guidelines, aspirin still widely used CVD general population. combination slow diffusion implementation self-medication, wide availability low-cost underlies these trends. Physician advice effective more needed. influence popular media also substantial. Appropriate requires additional clinician effort. Clinicaltrials.gov registered on December 1, 2014, NCT02607917.

Language: Английский

---

The Impact of pre-operative aspirin administration on free flap survival rate in lower extremity reconstructio n

European Journal of Trauma and Emergency Surgery, Journal Year: 2025, Volume and Issue: 51(1)

Published: Feb. 18, 2025

Language: Английский

---

Study on Rapid Detection Technology of Illegal Chemical Compounds Added to External Poultices

Biomedical Chromatography, Journal Year: 2025, Volume and Issue: 39(4)

Published: March 10, 2025

ABSTRACT Topical poultices and applied medical devices that can relieve a variety of cervical vertebrae lumbar pain may have illegal additives pharmaceutical drugs or analogues additional health risks, but customers not be aware what they are using. National Medical Products Administration reviewed approved “Supplementary test method for identification content determination 17 chemicals in affixed devices” drafted by Shandong Provincial Institute Devices Drug Packaging Inspection January 2022, the is simple sample processing difficult to extract chemical components paste cause phenomenon missing detection most added drugs. In this work, handling extraction methods been improved optimized, 47 batches was determined HPLC‐MS/MS detected 37 batches, non‐steroidal anti‐inflammatory drug nimesulide aspirin were samples. It shows there many people take several different supplements daily encounter quite high levels combined exposure toxic compounds.

Language: Английский

---

UPFs and Shortened Lifespans: Ultra-Processed Foods Linked to Accelerated Biological Aging; Consequences Across Human Body Systems and Implications for Associated Medical Specialties

Scientia. Technology, science and society., Journal Year: 2025, Volume and Issue: 2(3), P. 13 - 36

Published: March 1, 2025

Ultra-processed foods (UPFs) are defined by their high levels of refined carbohydrates, unhealthy fats, artificial additives, and preservatives. These contribute to biological aging through mechanisms such as chronic inflammation, oxidative stress, metabolic dysfunction. Inflammation, disruptions in insulin signaling key factors the development aging-related diseases, including cardiovascular disease, diabetes, neurodegenerative disorders. Specifically, advanced glycation end-products (AGEs) epigenetic modifications significantly acceleration disrupting cellular function, promoting tissue damage, driving disease development. UPF consumption is linked cancer, gastrointestinal disorders, obstetric gynecological conditions, a range adverse effects on various body systems. Reducing intake encouraging healthier dietary patterns crucial for mitigating impact UPFs related health conditions. For individuals unable transition whole food-based diets, pharmaceutical medical interventions offer alternatives reduce UPF-related aging. A combined approach pharmacologic therapies adjustments may optimize outcomes, with ongoing research into novel treatments further enhancing strategies counteract effects. This review examines accelerating aging, which they associated potential mitigate

Language: Английский

---

Low-Dose Rivaroxaban vs. Aspirin in Addition to Clopidogrel After Percutaneous Coronary Intervention in Coronary Atherosclerotic Heart Disease Patients with Gastrointestinal Disease

Cardiovascular Drugs and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Abstract Purpose Dual antiplatelet therapy (DAPT) is the cornerstone for patients with coronary atherosclerotic heart disease (CHD) undergoing percutaneous intervention (PCI) while increasing risk of bleeding, particularly when combined gastrointestinal (GID). Rivaroxaban 10 mg once daily widely used in Asia. This study compared effects low-dose rivaroxaban (10 daily) plus clopidogrel vs. DAPT CHD GID PCI. Methods In this prospective, single-center, randomized controlled trial, eligible PCI were (1:1) to either dual pathway inhibition (DPI) group (rivaroxaban 75 or (aspirin 100 daily). The primary outcome was Bleeding Academic Research Consortium (BARC) type 2–5 bleeding. secondary major adverse cardiovascular cerebrovascular events (MACCE), which included cardiac death, nonfatal myocardial infarction, ischemia-driven target vessel revascularization, all-cause stent thrombosis, and stroke during 6-month follow-up. Results A total 1042 enrolled analyzed (DPI, 522; DAPT, 520). Low-dose non-inferior BARC bleeding [8 (1.5%) 6 (1.2%), absolute difference 0.38%, 95% confidence interval (CI) (− 1.02–1.78), p < 0.0001 non-inferiority]. Abdominal pain significantly lower DPI ( = 0.009). Other abdominal discomforts, MACCE similar. Conclusions PCI, DAPT. Trial registration Chinese Clinical Registry ChiCTR2100044319. Registered on March 16, 2021.

Language: Английский

---

Investigating the role of aspirin on the mortality risk of sepsis-associated encephalopathy: a retrospective study

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 16

Published: March 26, 2025

Background Sepsis-associated encephalopathy (SAE) is one of the most common complications sepsis. Aspirin can serve as a promising therapeutic candidate and help improve patient outcomes in sepsis its complications. However, efficacy safety aspirin on SAE remains largely unexplored. Methods Patients for this retrospective study were collected from MIMIC-IV (version 3.0). Propensity score matching (PSM) was used to balance baseline characteristics between no group group. The association therapy mortality risk in-hospital, 30-day, 60-day, 90-day, 180-day analyzed by Cox proportional hazards model Kaplan–Meier method. E -value analysis evaluate potential influence unmeasured or unknown confounding factors. Subgroup applied explore differences effects clinical across these various groups. Results Our recruited 4,707 patients total, 2,518 enrolled after PSM. rate consistently significant lower than that curves revealed received exhibited notably higher survival compared those who did not. gastrointestinal hemorrhage had difference two Additionally, pre-ICU group, in-ICU decreased significantly high-dose experienced low-dose Conclusion could reduce 180-day, without increasing hemorrhage. benefits observed persisted regardless exposure timing.

Language: Английский

---

Determining the optimal use of approved drugs in oncology

The Lancet Oncology, Journal Year: 2025, Volume and Issue: 26(5), P. e282 - e294

Published: May 1, 2025

Language: Английский

---