Clinical Relevance and Mechanistic Underpinnings of Tyrosine Kinase Inhibitor Associated Cardiotoxicities DOI Creative Commons
Stefan Torelli, Vertica Agnihotri, Han Zhu

et al.

Current Treatment Options in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 27(1)

Published: Dec. 4, 2024

Abstract Purpose of Review Tyrosine kinase inhibitors (TKIs) are a major backbone cancer treatments across range malignancies. Observed adverse effects these targeted therapies include multitude clinically relevant cardiotoxicities distinct from those traditional cytotoxic chemotherapies. Over the past decade, TKI have gained growing recognition in field cardio-oncology. Here, we aim to review TKIs and incorporate preclinical mechanistic data. Recent Findings Each class generation within each been associated with unique cardiotoxicity profile. Broadly, documented arrythmia (atrial ventricular), heart failure, vascular complications (thrombosis, endothelial dysfunction, hypertension, atherosclerosis). progressing basic investigations begun unveil underpinnings toxicities, such as identifying off-target perturbations specific signaling pathways, but much more work is needed. Summary provide most cardiovascular toxicities raise awareness when caring for patients on drugs. exemplify complexity systemic manipulation fundamental molecular pathways effects. Translational research cardio-oncology paramount importance which can offer not only way better monitor (and prevent) known broadly understand define novel disease.

Language: Английский

Human Pluripotent Stem Cell–Derived Cardiomyocytes for COVID-19 Cardiovascular Complications: A Versatile In Vitro Model for Studying Acute and Chronic SARS-CoV-2 Infection DOI

Carmen Lopez-Munoz,

Noah Jackson Bowers,

Silvia Marchianò

et al.

Current Treatment Options in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 27(1)

Published: Feb. 20, 2025

Language: Английский

Citations

0
Towards advanced regenerative therapeutics to tackle cardio-cerebrovascular diseases DOI Creative Commons
Xi Chen,

Weiping Lin,

Micky D. Tortorella

et al.

American Heart Journal Plus Cardiology Research and Practice, Journal Year: 2025, Volume and Issue: 53, P. 100520 - 100520

Published: March 1, 2025

The development of vascularized organoids as novel modelling tools the human cardio-cerebrovascular system for preclinical research has become an essential platform studying tissues/organs personalized therapeutics during recent decades. Organ-on-chip technology is promising investigating physiological in vitro responses drug screening and advanced disease models. Vascularized tissue/organ-on-a-chip benefits every step discovery pipeline a tool with close genome relevance to investigate systems biology. Simultaneously, cardio-cerebrovascular-on-chip-integrated microfluidic serves alternative animal (patho-)physiological processes blood vessels embryonic disease. Integrated next-generation techniques, such three-dimensional bioprinting both cells matrix, may enable organoid-on-chip-based therapeutics.

Language: Английский

Citations

0
Nanomedicines for cardiovascular diseases: lessons learned and pathways forward DOI
Yufei Mao,

X.F. Shi,

Patricia Sun

et al.

Biomaterials, Journal Year: 2025, Volume and Issue: unknown, P. 123271 - 123271

Published: March 1, 2025

Language: Английский

Citations

0
Characteristics and pharmacological responsiveness in hiPSC models of inherited cardiomyopathy DOI Creative Commons

Merel Gerritse,

Willem B. van Ham, Chris Denning

et al.

Pharmacology & Therapeutics, Journal Year: 2025, Volume and Issue: unknown, P. 108845 - 108845

Published: April 1, 2025

Inherited cardiomyopathies are a major cause of heart failure in all age groups, often with an onset adolescence or early adult life. More than thousand variants approximately one hundred genes associated cardiomyopathies. Interestingly, many genetic display overlapping phenotypical defects patients, despite the diversity initial pathogenic variants. Understanding how underlying pathophysiology leads to these phenotypes, will improve insights into patient's disease course and creates opportunity for conceiving treatment strategies. Moreover, therapeutic strategies can be used treat multiple based on shared phenotypes. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) offer reliable, high-throughput models studying molecular cellular characteristics hereditary hiPSC-CMs produced relatively easily, either by directly originating them from introducing patient-specific healthy lines. This review evaluates 90 studies 24 cardiomyopathy-associated systematically summarises morphological functional phenotypes observed hiPSC-CMs. Additionally, applied cardiomyopathic compiled scored effectiveness. Multiple phenotypic were identified different variants, whereas certain only specific Based findings, common mechanisms, prospects, considerations future research discussed aim clinical translation patients.

Language: Английский

Citations

0
Innovative approaches to the management of recurrent atrial fibrillation, aortic dilation, and Brugada syndrome DOI
Filippo Crea

European Heart Journal, Journal Year: 2024, Volume and Issue: 45(40), P. 4245 - 4248

Published: Oct. 21, 2024

Language: Английский

Citations

0
In Vitro Models of Cardiovascular Disease: Embryoid Bodies, Organoids and Everything in Between DOI Creative Commons
Theodora M. Stougiannou, Konstantinos Christodoulou, Dimos Karangelis

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2714 - 2714

Published: Nov. 27, 2024

Cardiovascular disease comprises a group of disorders affecting or originating within tissues and organs the cardiovascular system; most, if not all, will eventually result in cardiomyocyte dysfunction death, negatively impacting cardiac function. Effective models are thus important for understanding crucial aspects progression, while recent advancements stem cell biology have allowed use populations to derive such models. These include three-dimensional (3D) as cell-based embryos (SCME) well organoids, many which frequently derived from embryoid bodies (EB). Not only can they recapitulate 3D form function, but developmental programs governing self-organization into more complex well. Many different organoids SCME constructs been generated years recreate tissue that give rise its cellular composition unique morphology. It is purpose this narrative literature review describe summarize recently organoid their recapitulation genetic acquired disease. Owing examined, focus on injury associated with embryonic/fetal tissues.

Language: Английский

Citations

0
Clinical Relevance and Mechanistic Underpinnings of Tyrosine Kinase Inhibitor Associated Cardiotoxicities DOI Creative Commons
Stefan Torelli, Vertica Agnihotri, Han Zhu

et al.

Current Treatment Options in Cardiovascular Medicine, Journal Year: 2024, Volume and Issue: 27(1)

Published: Dec. 4, 2024

Abstract Purpose of Review Tyrosine kinase inhibitors (TKIs) are a major backbone cancer treatments across range malignancies. Observed adverse effects these targeted therapies include multitude clinically relevant cardiotoxicities distinct from those traditional cytotoxic chemotherapies. Over the past decade, TKI have gained growing recognition in field cardio-oncology. Here, we aim to review TKIs and incorporate preclinical mechanistic data. Recent Findings Each class generation within each been associated with unique cardiotoxicity profile. Broadly, documented arrythmia (atrial ventricular), heart failure, vascular complications (thrombosis, endothelial dysfunction, hypertension, atherosclerosis). progressing basic investigations begun unveil underpinnings toxicities, such as identifying off-target perturbations specific signaling pathways, but much more work is needed. Summary provide most cardiovascular toxicities raise awareness when caring for patients on drugs. exemplify complexity systemic manipulation fundamental molecular pathways effects. Translational research cardio-oncology paramount importance which can offer not only way better monitor (and prevent) known broadly understand define novel disease.

Language: Английский

Citations

0