Nature Reviews Nephrology,
Journal Year:
2022,
Volume and Issue:
18(6), P. 378 - 395
Published: Feb. 22, 2022
Haemodialysis
(HD)
is
the
commonest
form
of
kidney
replacement
therapy
in
world,
accounting
for
approximately
69%
all
and
89%
dialysis.
Over
last
six
decades
since
inception
HD,
dialysis
technology
patient
access
to
have
advanced
considerably,
particularly
high-income
countries.
However,
HD
availability,
accessibility,
cost
outcomes
vary
widely
across
world
and,
overall,
rates
impaired
quality
life,
morbidity
mortality
are
high.
Cardiovascular
disease
affects
more
than
two-thirds
people
receiving
major
cause
accounts
almost
50%
mortality.
In
addition,
patients
on
high
symptom
loads
often
under
considerable
financial
strain.
Despite
many
advances
delivery
systems
that
been
achieved
treatment
was
first
developed,
poor
among
remain
a
public
health
concern.
Understanding
epidemiology
outcomes,
why
they
might
different
populations
how
be
improved
therefore
crucial,
although
this
goal
hampered
by
heterogeneity
monitoring
reporting
these
settings.
This
Review
examines
haemodialysis
—
clinical,
patient-reported
surrogate
regions
populations,
including
vulnerable
individuals.
The
authors
also
discuss
current
status
potential
strategies
improvement.
Circulation,
Journal Year:
2021,
Volume and Issue:
144(22)
Published: Oct. 28, 2021
Aim:
This
clinical
practice
guideline
for
the
evaluation
and
diagnosis
of
chest
pain
provides
recommendations
algorithms
clinicians
to
assess
diagnose
in
adult
patients.
Methods:
A
comprehensive
literature
search
was
conducted
from
November
11,
2017,
May
1,
2020,
encompassing
randomized
nonrandomized
trials,
observational
studies,
registries,
reviews,
other
evidence
on
human
subjects
that
were
published
English
PubMed,
EMBASE,
Cochrane
Collaboration,
Agency
Healthcare
Research
Quality
reports,
relevant
databases.
Additional
through
April
2021,
also
considered.
Structure:
Chest
is
a
frequent
cause
emergency
department
visits
United
States.
The
“2021
AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR
Guideline
Evaluation
Diagnosis
Pain”
based
contemporary
assessment
pain.
presents
an
evidence-based
approach
risk
stratification
diagnostic
workup
Cost-value
considerations
testing
have
been
incorporated,
shared
decision-making
with
patients
recommended.
International Journal of Molecular Sciences,
Journal Year:
2020,
Volume and Issue:
21(24), P. 9739 - 9739
Published: Dec. 20, 2020
Matrix
metalloproteinases
(MMPs)
are
a
family
of
zinc-dependent
extracellular
matrix
(ECM)
remodeling
endopeptidases
that
have
the
capacity
to
degrade
almost
every
component
ECM.
The
degradation
ECM
is
great
importance,
since
it
related
embryonic
development
and
angiogenesis.
It
also
involved
in
cell
repair
tissues.
When
expression
MMPs
altered,
can
generate
abnormal
This
initial
cause
chronic
degenerative
diseases
vascular
complications
generated
by
diabetes.
In
addition,
this
process
has
an
association
with
neurodegeneration
cancer
progression.
Within
ECM,
tissue
inhibitors
(TIMPs)
inhibit
proteolytic
activity
MMPs.
TIMPs
important
regulators
turnover,
remodeling,
cellular
behavior.
Therefore,
(similar
MMPs)
modulate
angiogenesis,
proliferation,
apoptosis.
An
interruption
balance
between
been
implicated
pathophysiology
progression
several
diseases.
review
focuses
on
participation
both
(e.g.,
MMP-2
MMP-9)
TIMP-1
TIMP-3)
physiological
processes
how
their
regulation
associated
human
inclusion
current
strategies
mechanisms
MMP
inhibition
new
therapies
targeting
was
considered.
New England Journal of Medicine,
Journal Year:
2019,
Volume and Issue:
381(19), P. 1820 - 1830
Published: Sept. 28, 2019
Long-term
outcomes
after
percutaneous
coronary
intervention
(PCI)
with
contemporary
drug-eluting
stents,
as
compared
coronary-artery
bypass
grafting
(CABG),
in
patients
left
main
artery
disease
are
not
clearly
established.
