Innovative Therapeutic Strategies for Myocardial Infarction Across Various Stages: Non-Coding RNA and Stem Cells DOI Open Access

Bingqi Zhuang,

Chongning Zhong, Yuting Ma

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 26(1), P. 231 - 231

Published: Dec. 30, 2024

Myocardial infarction (MI) is a highly challenging and fatal disease, with diverse challenges arising at different stages of its progression. As such, non-coding RNAs (ncRNAs), which can broadly regulate cell fate, stem cells multi-differentiation potential are emerging as novel therapeutic approaches for treating MI across various stages. NcRNAs, including microRNAs (miRNAs) long (LncRNAs), directly participate in regulating intracellular signaling pathways, influence cardiac angiogenesis, promote the repair infarcted myocardium. Currently, commonly used medicine, such mesenchymal (MSCs) induced pluripotent (iPSCs), differentiate into human types without ethical concerns. When combined ncRNAs, these more effectively induce directed differentiation, angiogenesis heart, replenish normal cells. Additionally, cell-derived exosomes, contain improve myocardial damage region through paracrine mechanisms. However, our understanding specific roles mechanisms cells, exosomes secreted by during remains limited. Therefore, this review systematically categorizes MI, aiming to summarize direct regulatory effects ncRNAs on an myocardium points disease Moreover, it explores therapy exosome complex pathological evolution process. The objective was provide insights strategies open new research directions application field repair.

Language: Английский

Ion channel dysfunction and fibrosis in atrial fibrillation: Two sides of the same coin DOI
Gianmarco Arabia, Maria Giulia Bellicini, Angelica Cersosimo

et al.

Pacing and Clinical Electrophysiology, Journal Year: 2024, Volume and Issue: 47(3), P. 417 - 428

Published: Feb. 20, 2024

Abstract Background Atrial fibrillation (AF) is a common heart rhythm disorder that associated with an increased risk of stroke and failure (HF). Initially, association between AF ion channel dysfunction was identified, classifying the pathology as predominantly electrical disease. More recently it has been recognized fibrosis structural atrial remodeling play driving role in development this arrhythmia also these cases. Purpose Understanding genetic determined could be important to better comprise pathophysiology refine its management nongenetic forms. In review we analyze epigenetic mechanisms responsible for their link fibrosis, then will consider analogies pathophysiological mechanism AF, discuss consequent therapeutic options.

Language: Английский

Citations

10
Non-Coding RNA: A Key Regulator in the Glutathione-GPX4 Pathway of Ferroptosis DOI Creative Commons
Md Sadique Hussain, Gaurav Gupta, Moyad Shahwan

et al.

Non-coding RNA Research, Journal Year: 2024, Volume and Issue: 9(4), P. 1222 - 1234

Published: May 20, 2024

Ferroptosis, a form of regulated cell death, has emerged as crucial process in diverse pathophysiological states, encompassing cancer, neurodegenerative ailments, and ischemia-reperfusion injury. The glutathione (GSH)-dependent lipid peroxidation pathway, chiefly governed by peroxidase 4 (GPX4), assumes an essential part driving ferroptosis. GPX4, the principal orchestrator ferroptosis, garnered significant attention across cardiovascular, neuroscience domains over past decade. Noteworthy investigations have elucidated indispensable functions ferroptosis numerous diseases, including tumorigenesis, wherein robust within cells can impede tumor advancement. Recent research underscored complex regulatory role non-coding RNAs (ncRNAs) regulating GSH-GPX4 network, thus influencing cellular susceptibility to This exhaustive review endeavors probe into multifaceted processes which ncRNAs control network Specifically, we delve miRNAs, lncRNAs, circRNAs GPX4 expression impacting Moreover, discuss clinical implications dysregulated interactions between several conditions, underscoring their capacity viable targets for therapeutic intervention. Additionally, explores emerging strategies aimed at targeting modulate pathway manipulate advantage. A comprehensive understanding these intricate networks furnishes insights innovative avenues diseases associated with perturbed thereby laying groundwork interventions ferroptosis-related pathological conditions.

Language: Английский

Citations

10
Plasma expression level of Hsa_circ_0099734 is associated with atrial fibrillation and its poor prognosis DOI

Lanqing Yang,

Zhiquan Yuan, Yanxiu Chen

et al.

International Journal of Cardiology, Journal Year: 2025, Volume and Issue: unknown, P. 133202 - 133202

Published: March 1, 2025

Language: Английский

Citations

0
Role of circadian transcription factor REV-ERB in cardiovascular diseases: a review DOI Creative Commons
Chunling Wang, Jia‐Shu Yang, Junying Yuan

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 4, 2025

Circadian rhythm, or the biological clock, is an intrinsic timing system present in organisms that operates on a cycle of approximately 24 h. Nearly every cell human body adheres to specific circadian governing various processes essential for overall health. REV-ERB, key clock-regulating gene, plays crucial role maintaining precision these rhythms. This gene influences many downstream targets associated with diverse pathophysiological processes, including metabolism, autophagy, immunity, inflammation, and aging across multiple organs. REV-ERB specifically impacts cardiac systolic function by regulating myocardial energy metabolism. In contemporary society, health well-being are increasingly challenged disruptions such as night shifts, late-night activities, jet lag. These often lead rhythm disorders, which now being linked heart diseases. review explored potential cardiovascular system. Beyond its regulation, could significantly influence physiological pathological related health, atherosclerosis, ischemia/reperfusion injury, failure. Mechanistically, regulate glucose lipid ferroptosis, mitochondrial function. The highlighted protective roles underlying mechanisms diseases, suggesting multidisciplinary research may provide basis breakthroughs REV-ERB-targeted therapies disorders.

Language: Английский

Citations

0
ncRS: A resource of non-coding RNAs in sepsis DOI

Baocai Zhong,

Yongfang Dai,

Li Chen

et al.

Computers in Biology and Medicine, Journal Year: 2024, Volume and Issue: 172, P. 108256 - 108256

Published: March 11, 2024

Language: Английский

Citations

3
Atrial remodelling and atrial fibrillation self-sustaining: the role of circulating circDGCR8 DOI
Yuanfeng Gao, Ying Dong, Nan Jiang

et al.

Cardiovascular Research, Journal Year: 2025, Volume and Issue: unknown

Published: May 8, 2025

Abstract Aims The prediction of atrial fibrillation (AF) progression and post-ablation recurrence is currently based on empirical estimates, leading to suboptimal predictive accuracy. This study investigates whether remodelling, a key factor in the severity cardiomyopathy, could serve as shared substrate influencing both AF recurrence. We aimed identify circular RNAs (circRNAs) associated with remodelling evaluate their ability predict Methods results assessed differential expression plasma circRNAs between paroxysmal (PAF) persistent (PsAF) patients using microarray analysis. Selected candidate were validated through qPCR following rigorous statistical bioinformatics circDGCR8 was consistently found be up-regulated PsAF compared PAF patients. Additionally, significantly human fibroblasts treated angiotensin II (AngII). Gain- loss-of-function studies suggested that promote at cellular level by enhancing collagen production fibroblast proliferation. Overexpression cardiac altered gene spectrum, impacting pathways including IL-17 signalling TNF signalling. Moreover, levels positively correlated fibrosis, indicated increased percentages low voltage zones. value evaluated two cohorts: (i) monitored for 36 months endpoint, (ii) who underwent radiofrequency ablation followed 12 assess In cohorts, higher risks Conclusion Our suggest circDGCR8, holds potential biomarker

Language: Английский

Citations

0
lncRNA CDKN2B-AS1 is downregulated in patients with ventricular fibrillation in acute myocardial infarction DOI Creative Commons
Ricardo Pan-Lizcano, Lucía Núñez, Pablo Piñón-Esteban

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(5), P. e0304041 - e0304041

Published: May 21, 2024

Ventricular fibrillation (VF) in acute myocardial infarction (AMI) is the main cause of deaths occurring phase an ischemic event. Although it known that genetics may play important role this pathology, possible long non-coding RNAs (lncRNA) has never been studied. Therefore, aim work to study expression 10 lncRNAs patients with and without VF AMI. For purpose, CDKN2B-AS1, KCNQ1OT1, LIPCAR, MALAT1, MIAT, NEAT1, SLC16A1-AS1 , lnc-TK2-4 : 2 TNFRSF14-AS1 UCA1 were analyzed. After analysis Bonferroni correction, lncRNA CDKN2B-AS showed a statistical significance lower (P values 2.514 x −5 ). In silico revealed six proteins could be related effect CDKN2B-AS1 AGO3, PLD4, POU4F1, ZNF26, ZNF326 ZNF431. These predicted have low cardiac expression, although there no literature indicating potential relationship Thus, shows significant AMI vs Literature data suggest CDKN2B1-AS miR-181a/SIRT1 pathway.

Language: Английский

Citations

1
CCRR regulate MYZAP-PKP2-Nav1.5 signaling pathway in atrial fibrillation following myocardial infarction DOI Creative Commons
Lina Xuan, Jianjun Guo,

Huishan Luo

et al.

iScience, Journal Year: 2024, Volume and Issue: 27(11), P. 111102 - 111102

Published: Oct. 5, 2024

Language: Английский

Citations

1
Up-regulated novel-miR-17 promotes hypothermic reperfusion arrhythmias by negatively targeting Gja1 and mediating activation of the PKC/c-Jun signaling pathway DOI
Jing Yi, Kaiyuan Chen, Ying Cao

et al.

Journal of Molecular and Cellular Cardiology, Journal Year: 2024, Volume and Issue: 193, P. 1 - 10

Published: May 23, 2024

Language: Английский

Citations

1
Novel insights into the molecular mechanisms governing embryonic epicardium formation DOI Open Access
Rita Carmona, Carmen López‐Sánchez, Virginio García‐Martínez

et al.

Published: Oct. 9, 2023

The embryonic epicardium originates from the proepicardium, an extracardiac primordium constituted by a cluster of mesothelial cells. In early embryos, is characterized squamous cell epithelium resting on myocardium surface. Subsequently, it invades subepicardial space and thereafter means epithelial-mesenchymal transition. Within myocardium, epicardial-derived cells present multilineage potential, later differentiating into smooth muscle contributing both to coronary vasculature cardiac fibroblasts in mature heart. Over last decades, we have progressively increased our understanding those cellular molecular mechanisms driving proepicardial/embryonic formation. This study provides state-of-the-art review transcriptional emerging post-transcriptional involved formation differentiation epicardium.

Language: Английский

Citations

2