Autism Spectrum Disorder, Oral Implications, and Oral Microbiota DOI Creative Commons

Emiliana D’Angelo,

Fausto Fiori,

Giuseppe Andrea Ferraro

et al.

Children, Journal Year: 2025, Volume and Issue: 12(3), P. 368 - 368

Published: March 15, 2025

Background/Objectives: Autism spectrum disorder (ASD) is a complex neurodevelopmental characterized by difficulties in social interaction, communication, and repetitive behaviors. Recent evidence indicates significant relationship between ASD imbalances microbiota, particularly the oral gastrointestinal areas. This review examines impact of self-injurious behaviors (SIB), sensory sensitivity, dietary choices on comorbidities associated with ASD. Methods: An extensive literature was conducted using PubMed Scopus. The focus human studies full-text availability, utilizing search terms related to ASD, health, disorders. research evaluated for methodological quality its relevance connections Results: Individuals face unique health challenges, including injuries from increased which complicate hygiene care. Selective eating can lead nutritional deficiencies worsen issues. Dysbiosis gut marked altered levels acetate, propionate, butyrate, interferes gut-brain oral-brain connections, contributing behavioral neurological symptoms. Treatment options such as probiotics, fecal microbiota transfer, integration therapies potentially alleviate symptoms improve life. Conclusions: suggests bidirectional influence through neuroinflammatory mechanisms metabolic disturbances. Proactive strategies focusing dental may help reduce enhance overall management underscoring need further into microbiota–host interactions their therapeutic potential.

Language: Английский

Autism Spectrum Disorder, Oral Implications, and Oral Microbiota DOI Creative Commons

Emiliana D’Angelo,

Fausto Fiori,

Giuseppe Andrea Ferraro

et al.

Children, Journal Year: 2025, Volume and Issue: 12(3), P. 368 - 368

Published: March 15, 2025

Background/Objectives: Autism spectrum disorder (ASD) is a complex neurodevelopmental characterized by difficulties in social interaction, communication, and repetitive behaviors. Recent evidence indicates significant relationship between ASD imbalances microbiota, particularly the oral gastrointestinal areas. This review examines impact of self-injurious behaviors (SIB), sensory sensitivity, dietary choices on comorbidities associated with ASD. Methods: An extensive literature was conducted using PubMed Scopus. The focus human studies full-text availability, utilizing search terms related to ASD, health, disorders. research evaluated for methodological quality its relevance connections Results: Individuals face unique health challenges, including injuries from increased which complicate hygiene care. Selective eating can lead nutritional deficiencies worsen issues. Dysbiosis gut marked altered levels acetate, propionate, butyrate, interferes gut-brain oral-brain connections, contributing behavioral neurological symptoms. Treatment options such as probiotics, fecal microbiota transfer, integration therapies potentially alleviate symptoms improve life. Conclusions: suggests bidirectional influence through neuroinflammatory mechanisms metabolic disturbances. Proactive strategies focusing dental may help reduce enhance overall management underscoring need further into microbiota–host interactions their therapeutic potential.

Language: Английский

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