Sperm storage reduces sperm and embryo quality in animals DOI Creative Commons
Krish Sanghvi,

Rebecca Dean,

Shinichi Nakagawa

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract In many animals, sperm are stored for extended periods either in the reproductive tracts of males before ejaculation, or females after copulation. Sperm storage reduces risk limitation both sexes and avoids costs female re-mating. However, can lead to post-meiotic senescence, i.e. within-sperm-age-dependent deterioration, potentially impacting conceived offspring lowering male fitness. Yet, extent magnitude such deterioration variables modulating it during not well understood. Using a meta-analysis across humans (115 studies) non-human animals (56 studies from 30 species), we investigate how in-vivo affects quality, fertilisation success, quality. humans, leads greater oxidative stress DNA damage, viability motility. other performance embryo quality decline. We identify duration storage, design used sampling individuals, sex individual storing as important moderators effects storage. These findings have key biomedical implications, including optimising timing ejaculation fertility clinics captive breeding programs. Overall, our results reveal mechanisms that cause fitness consequences provide evolutionary insights into sex-specific adaptations mitigate detrimental

Language: Английский

Sperm storage reduces sperm and embryo quality in animals DOI Creative Commons
Krish Sanghvi,

Rebecca Dean,

Shinichi Nakagawa

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract In many animals, sperm are stored for extended periods either in the reproductive tracts of males before ejaculation, or females after copulation. Sperm storage reduces risk limitation both sexes and avoids costs female re-mating. However, can lead to post-meiotic senescence, i.e. within-sperm-age-dependent deterioration, potentially impacting conceived offspring lowering male fitness. Yet, extent magnitude such deterioration variables modulating it during not well understood. Using a meta-analysis across humans (115 studies) non-human animals (56 studies from 30 species), we investigate how in-vivo affects quality, fertilisation success, quality. humans, leads greater oxidative stress DNA damage, viability motility. other performance embryo quality decline. We identify duration storage, design used sampling individuals, sex individual storing as important moderators effects storage. These findings have key biomedical implications, including optimising timing ejaculation fertility clinics captive breeding programs. Overall, our results reveal mechanisms that cause fitness consequences provide evolutionary insights into sex-specific adaptations mitigate detrimental

Language: Английский

Citations

0