Interdisciplinary fetal-neonatal neurology training applies neural exposome perspectives to neurology principles and practice

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 15, 2024

An interdisciplinary fetal-neonatal neurology (FNN) program over the first 1,000 days teaches perspectives of neural exposome that are applicable across life span. This curriculum strengthens neonatal neurocritical care, pediatric, and adult training objectives. Teaching at maternal-pediatric hospital centers optimally merges reproductive, pregnancy, pediatric approaches to healthcare. Phenotype–genotype expressions health or disease pathways represent a dynamic developmental time. The science uncertainty applied FNN re-enforces importance shared clinical decisions minimize bias reduce cognitive errors. Trainees select mentoring committee participants will maximize their learning experiences. Standardized questions oral presentations monitor educational progress. Master doctoral defense preparation competitive research funding can be goals for specific individuals. principles practice offer an understanding gene–environment interactions recognizes effects reproductive on maternal-placental-fetal triad, neonate, child, adult. Pre-conception prenatal adversities potentially diminish life-course brain health. Endogenous exogenous toxic stressor interplay (TSI) alters through maladaptive neuroplasticity. Developmental disorders epilepsy primarily expressed during days. Communicable noncommunicable illnesses continue interact with express diverse neurologic lifespan, particularly critical/sensitive time periods adolescence senescence. Anomalous destructive fetal neuropathologic lesions change this developmental-aging continuum. integrated placental, neonatal, childhood, offers perspective exposome. Exosome promises improved monitoring drug delivery starting pregnancy. origins anticipate diagnoses interventions benefit successive generations. Addressing care disparities in Global South high-income country medical deserts require constructive dialogue among stakeholders achieve equity. Population policies capital strategy reduces global burden diseases by applying practice. integrative approach prolong survival quality persons lifespan confronted neurological disorders.

Language: Английский

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A general exposome factor explains individual differences in functional brain network topography and cognition in youth

Developmental Cognitive Neuroscience, Journal Year: 2024, Volume and Issue: 66, P. 101370 - 101370

Published: April 1, 2024

Childhood environments are critical in shaping cognitive neurodevelopment. With the increasing availability of large-scale neuroimaging datasets with deep phenotyping childhood environments, we can now build upon prior studies that have considered relationships between one or a handful environmental and features at time. Here, characterize combined effects hundreds inter-connected co-occurring child's environment ("exposome") investigate associations each unique, multidimensional pattern functional brain network organization ("functional topography") cognition. We apply data-driven computational models to measure exposome define personalized networks pre-registered analyses. Across matched discovery (n=5,139, 48.5% female) replication (n=5,137, 47.1% samples from Adolescent Brain Cognitive Development study, was associated current (ages 9-10) future 11-12) Changes were also changes cognition after accounting for baseline scores. Cross-validated ridge regressions revealed is reflected topography predict performance across domains. Importantly, single capturing could more accurately parsimoniously than wealth data, highlighting importance children's complex,

Language: Английский

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Classification of Suicide Attempt Risk Using Environmental and Lifestyle Factors in 3 Large Youth Cohorts

JAMA Psychiatry, Journal Year: 2024, Volume and Issue: 81(10), P. 1020 - 1020

Published: July 17, 2024

Importance Suicide is the third-leading cause of death among US adolescents. Environmental and lifestyle factors influence suicidal behavior can inform risk classification, yet quantifying incorporating them in assessment presents a significant challenge for reproducibility clinical translation. Objective To quantify aggregate contribution environmental to youth suicide attempt classification. Design, Setting, Participants This was cohort study 3 samples: 2 national longitudinal cohorts from UK 1 tertiary pediatric hospital. An exposome-wide association (ExWAS) approach used identify protective compute exposomic scores. Logistic regression models were applied test associations model fit scores with attempts independent data. Youth Adolescent Brain Cognitive Development (ABCD) study, Millennium Cohort Study (MCS), Children’s Hospital Philadelphia emergency department (CHOP-ED) included study. Exposures A single-weighted score that sums environmental/lifestyle factors. Main Outcome Measure Self-reported attempt. Results total 40 364 this analysis: 11 564 ABCD (3 waves assessment; mean [SD] age, 12.0 [0.7] years; 6034 male [52.2%]; 344 attempted [3.0%]; 1154 study), 9000 MCS (mean 17.2 [0.3] 4593 female [51.0%]; 661 [7.3%]; 2864 cohort), 19 800 CHOP-ED 15.3 [1.5] 12 937 [65.3%]; 2051 [10.4%]; 36 cohort). In discovery subsample, ExWAS identified 99 exposures significantly associated single weighted an testing subsample (odds ratio [OR], 2.2; 95% CI, 2.0-2.6; P < .001) explained 17.6% variance (based on pseudo- R ) over above by sex, race, ethnicity (2.8%) family history (6.3%). Findings consistent (explaining 22.6% 19.3% attempt, respectively) despite clinical, demographic, exposure differences. all cohorts, compared at median quintile score, top fifth substantially more likely have made (OR, 4.3; 2.6-7.2 study; OR, 3.8; 2.7-5.3 cohort; 5.8; 4.7-7.1 Conclusions Relevance suggest provided generalizable method classification be diverse samples or population settings.

Language: Английский

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Mapping the exposome of mental health: exposome-wide association study of mental health outcomes among UK Biobank participants

Psychological Medicine, Journal Year: 2025, Volume and Issue: 55

Published: Jan. 1, 2025

Abstract Background Dissecting the exposome linked to mental health outcomes can help identify potentially modifiable targets improve well-being. However, multiplicity of exposures and complexity phenotypes pose a challenge that requires data-driven approaches. Methods Guided by our previous systematic approach, we conducted hypothesis-free exposome-wide analyses factors associated with 7 psychiatric diagnostic domains 19 symptom dimensions in 157,298 participants from UK Biobank Mental Health Survey. After quality control, 294 environmental, lifestyle, behavioral, economic variables were included. An Exposome-Wide Association Study was per outcome two equally split datasets. Variables each then tested multivariable model. Results Across all dimensions, top three childhood adversities traumatic events. Cannabis use common disorders (depressive, anxiety, psychotic, bipolar manic disorders), ORs ranging 1.10 1.79 models. Additionally, differential associations identified between specific outcomes—such as neurodevelopmental disorders, eating self-harm behaviors—and exposures, including early life experiences (being adopted), lifestyle (time spent using computers), dietary habits (vegetarian diet). Conclusions This comprehensive mapping revealed several factors, particularly those previously well-studied shared across phenotypes, providing further support for transdiagnostic pathoetiology. Our findings also showed distinct relations might exist. Continued research through multimodal mechanistic studies guided framework is required better inform public policies.

Language: Английский

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Identification of exposome clusters based on societal, social, built and natural environment – results of the ABCD cohort study

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109335 - 109335

Published: Feb. 1, 2025

Language: Английский

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Interaction between Neighborhood Exposome and Genetic Risk in Child Psychotic-like Experiences

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Persistent distressing psychotic-like experiences (PLE) among children may be driven by genetics and neighborhood environmental exposures. However, the gene-environment interaction to persistent PLE is unknown. The study included 6,449 participants from Adolescent Brain Cognitive Development Study. Genetic risk was measured a multi-ancestry schizophrenia polygenic score (SCZ-PRS). Multi-dimensional neighborhood-level exposures were used form exposome (NE) score. SCZ-PRS not statistically significantly associated with odds of (OR = 1.04, 95% CI: 0.97, 1.13, P = 0.280), whereas NE 1.15, 1.05, 1.26, 0.003). association between attenuated as increased for 0.92, 0.86, 1.00, 0.039). findings indicate that detrimental exposures, particularly low genetic risks.

Language: Английский

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Independent and joint effects of genomic and exposomic loads for schizophrenia on psychotic experiences in adolescents of European ancestry

Schizophrenia, Journal Year: 2025, Volume and Issue: 11(1)

Published: Feb. 22, 2025

Abstract This study aimed to assess the independent and joint associations of genomic exposomic liabilities for schizophrenia with distressing psychotic experiences (PEs) their persistence in early adolescence. The Adolescent Brain Cognitive Development Study data from children European ancestry were used ( N = 5122). primary outcome was past-month PEs at 3-year follow-up. Secondary outcomes varying cutoffs persistence. Multilevel logistic regression models test binary modes (>75th percentile) polygenic risk score (PRS-SCZ 75 ) exposome (ES-SCZ on outcomes. Relative excess due interaction (RERI) calculation indicated additive interaction. When analyzed independently, PRS-SCZ not significantly associated but lifetime (OR 1.29 [95% CI 1.08, 1.53]) repeating ≥2 waves 1.34 1.65]); whereas, ES-SCZ consistently all outcomes, increasing strength association as a function (one wave: OR 2.77 2.31, 3.31]; two waves: 3.16 2.54, 3.93]; three 3.93 2.86, 5.40]; four 3.65 2.34, 5.70]). considered jointly, did additively interact predict showed significant interactions (RERI 1.26 [95%CI 0.14, 2.38]) 1.79 0.35, 3.23]). Genomic independently jointly

Language: Английский

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Beyond Discrete Classifications: A Computational Approach to the Continuum of Cognition and Behavior in Children

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Abstract Psychiatry is undergoing a shift toward precision medicine, demanding personalized approaches that capture the complexity of cognition and behavior. Here, we introduce novel referential four robust, replicable, generalizable cognitive behavioral profiles. These were derived from most prominent pediatric cohort (n=10,843) validated in two independent cohorts (n=195 n=271). We demonstrate profiles’ longitudinal stability consistency with clinical diagnoses while exposing critical discrepancies across parent-reported, youth-reported, expert-derived diagnoses. Beyond validation, showcase real-world utility our approach by linking profiles to environmental factors, revealing associations between parental influences youths’ Our fuzzy profiling framework moves beyond discrete classification, offering powerful tool refine psychiatric evaluation intervention. provide an open-source framework, enabling researchers clinicians fast-track implementation foster data-driven, domain-based diagnosis. findings advocate for broadening scope assessment.

Language: Английский

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Mediating role of trauma connecting psychiatric family history and adolescent mental health

Biological Psychiatry Global Open Science, Journal Year: 2025, Volume and Issue: unknown, P. 100525 - 100525

Published: May 1, 2025

Language: Английский

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Probing the digital exposome: associations of social media use patterns with youth mental health

NPP—Digital Psychiatry and Neuroscience, Journal Year: 2024, Volume and Issue: 2(1)

Published: April 23, 2024

Abstract Recently, the U.S. Surgeon General issued an advisory highlighting lack of knowledge about safety ubiquitous social media use on adolescent mental health. For many youths, can become excessive and contribute to frequent exposure adverse peer interactions (e.g., cyberbullying, hate speech). Nonetheless, is complex, although there are clear challenges, it also create critical new avenues for connection, particularly among marginalized youth. In current project, we leverage a large nationally diverse sample adolescents from Adolescent Brain Cognitive Development (ABCD) Study assessed between 2019–2020 ( N = 10,147, M age 12.0, 48% assigned female at birth, 20% Black, Hispanic) test associations specific facets type apps used, time spent, addictive patterns use) overall Specifically, data-driven exposome-wide association was applied generate digital exposomic risk scores that aggregate cumulative burden exposure. This included general usage, having secret accounts, problematic/addictive behavior, other factors. validation models, explained substantial variance in child-reported psychopathology, history suicide attempt, over above sociodemographics, non-social screentime, non-digital adversity abuse, poverty). Furthermore, differences shed insight into health disparities, youth color sexual gender minority Our work using approach supports notion exposures, particular use, US adolescents.

Language: Английский

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