G3 Genes Genomes Genetics, Journal Year: 2024, Volume and Issue: 14(12)
Published: Dec. 1, 2024
Language: Английский
Published: Nov. 11, 2024
The aye-aye (
Language: Английский
Citations
8
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
ABSTRACT The distribution of fitness effects (DFE) characterizes the range selection coefficients from which new mutations are sampled, and thus holds a fundamentally important role in evolutionary genomics. To date, DFE inference primates has been largely restricted to haplorrhines, with limited data availability leaving other suborder primates, strepsirrhines, under-explored. advance our understanding population genetics this taxonomic group, we here map exonic divergence aye-ayes ( Daubentonia madagascariensis ) – only extant member Daubentoniidae family Strepsirrhini suborder. We further infer highly-endangered species, utilizing recently published high-quality annotated reference genome, well-supported model demographic history, as well both direct indirect estimates underlying mutation recombination rates. inferred is generally characterized by greater proportion deleterious relative humans, providing evidence larger long-term effective size. In addition however, immune-related sensory-related genes were found be amongst most rapidly evolving aye-aye genome.
Language: Английский
Citations
1
Molecular Biology and Evolution, Journal Year: 2025, Volume and Issue: 42(3)
Published: March 1, 2025
Given the many levels of biological variation in mutation rates observed to date primates-spanning from species individuals genomic regions-future steps our understanding rate evolution will not only be aided by a greater breadth coverage across primate clade but also depth as afforded an evaluation multiple trios within individual species. In order help bridge these gaps, we here present analysis representing one most basal splits on tree (aye-ayes), combining whole-genome sequencing seven parent-offspring three-generation pedigree with novel computational pipeline that takes advantage recently developed pan-genome graphs, thereby circumventing application (highly subjective) quality metrics has previously been shown result notable differences detection de novo mutations and ultimately estimates rates. This deep sampling enabled both detailed picture parental age effects sex dependency rates, which compare studied primates, provided unique insights into nature genetic endangered primates planet.
Language: Английский
Citations
1
Published: Nov. 11, 2024
Gaining a better understanding of rates and patterns meiotic recombination is crucial for improving evolutionary genomic modelling, with applications ranging from demographic to selective inference. Although previous research has provided important insights into the landscape crossovers in humans other haplorrhines, our both considerably more common outcome (i.e., non-crossovers) as well landscapes distantly-related primates strepsirrhines) remains limited owing difficulties associated identification non-crossover tracts species sampling. Thus, order elucidate this under-studied branch primate clade, we here characterize crossover aye-ayes utilizing whole-genome sequencing data six three-generation pedigrees three two-generation multi-sibling families, so doing provide novel process shaping diversity one world's most critically endangered species.
Language: Английский
Citations
7
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 11, 2024
Given the many levels of biological variation in mutation rates observed to date primates - spanning from species individuals genomic regions future steps our understanding rate evolution will be aided by both a greater breadth coverage across primate clade, but also depth as afforded an evaluation multiple trios within individual species. In order help bridge these gaps, we here present analysis representing one most basal splits on tree (aye-ayes), combining whole-genome sequencing seven parent-offspring three-generation pedigree with novel computational pipeline that takes advantage recently developed pan-genome graphs, thereby circumventing application (highly subjective) quality metrics has previously been shown result notable differences detection
Language: Английский
Citations
7
Published: Nov. 11, 2024
The nocturnal aye-aye,
Language: Английский
Citations
7
Published: Nov. 11, 2024
Aye-ayes (
Language: Английский
Citations
7
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 28, 2024
The rate of input new genetic mutations, and the at which that variation is reshuffled, are key evolutionary processes shaping genomic diversity. Importantly, these rates vary not just across populations species, but also individual genomes. Despite previous studies having demonstrated failing to account for heterogeneity genome can bias inference both selective neutral population processes, mutation recombination maps have date only been generated a relatively small number organisms. Here, we infer such fine-scale aye-aye ( Daubentonia madagascariensis ) - highly endangered strepsirrhine represents one earliest splits in primate clade, thus stands as an important outgroup more commonly-studied haplorrhines utilizing recently released fully-annotated combined with high-quality sequencing data. We compare our indirectly inferred pedigree-based estimates, finding further evidence low aye-ayes compared other primates.
Language: Английский
Citations
2
G3 Genes Genomes Genetics, Journal Year: 2024, Volume and Issue: 14(12)
Published: Dec. 1, 2024
Language: Английский
Citations
1