Convergent pathways of reductive mitochondrial evolution characterised with hypercubic inference DOI Creative Commons
Robert C. Glastad, Iain G. Johnston

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: May 4, 2025

Abstract For a striking example of mitochondrial behaviour beyond ATP generation, consider mitochondrion-related organelles (MROs). Hydrogenosomes, mitosomes, and other reduced forms have evolved through the loss physical functional features, from individual ETC complexes to oxidative phosphorylaytion very ability produce (and further). Reduction mitochondria is dramatic convergent evolution, occuring in every eukaryotic kingdom many parallel times. Here, we use hypercubic inference, class methods evolutionary accumulation modelling (EvAM), explore pathways reduction across eukaryotes. We find that most MRO diversity can be explained by small variations on two distinct pathways, starting with either Complex I or Complexes III/IV, which tend proceed over different characteristic timescales. show clades, including ciliates apicomplexans, reflect particular instances these pathways. Using metabolic modelling, connect structure impact changes involved, suggesting plausible explanation for dramatically nature reductive evolution. discuss this approach connection related theory genetic organisms.

Language: Английский

Convergent pathways of reductive mitochondrial evolution characterised with hypercubic inference DOI Creative Commons
Robert C. Glastad, Iain G. Johnston

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: May 4, 2025

Abstract For a striking example of mitochondrial behaviour beyond ATP generation, consider mitochondrion-related organelles (MROs). Hydrogenosomes, mitosomes, and other reduced forms have evolved through the loss physical functional features, from individual ETC complexes to oxidative phosphorylaytion very ability produce (and further). Reduction mitochondria is dramatic convergent evolution, occuring in every eukaryotic kingdom many parallel times. Here, we use hypercubic inference, class methods evolutionary accumulation modelling (EvAM), explore pathways reduction across eukaryotes. We find that most MRO diversity can be explained by small variations on two distinct pathways, starting with either Complex I or Complexes III/IV, which tend proceed over different characteristic timescales. show clades, including ciliates apicomplexans, reflect particular instances these pathways. Using metabolic modelling, connect structure impact changes involved, suggesting plausible explanation for dramatically nature reductive evolution. discuss this approach connection related theory genetic organisms.

Language: Английский

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