A meiotic driver hijacks an epigenetic reader to disrupt mitosis in noncarrier offspring

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(45)

Published: Nov. 1, 2024

Killer meiotic drivers (KMDs) are selfish genetic elements that distort Mendelian inheritance by selectively killing products lacking the KMD element, thereby promoting their own propagation. Although KMDs have been found in diverse eukaryotes, only a limited number of them characterized at molecular level, and mechanisms remain largely unknown. In this study, we identify gene previously deemed essential for cell survival fission yeast

Language: Английский

Functional and evolutionary constraints ofwtfkiller meiotic drivers

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 27, 2024

Killer meiotic drivers are selfish DNA loci that sabotage the gametes do not inherit them from a driver+/driver- heterozygote. These often employ toxic proteins target essential cellular functions to cause destruction of driver- gametes. Identifying mechanisms can expand our understanding infertility and reveal novel insights about targeted by drivers. In this work, we explore molecular underlying

Language: Английский