Genetic basis of resistance in hosts facing alternative infection strategies by a virulent bacterial pathogen DOI Creative Commons
Eglantine Mathieu‐Bégné, Sabrina Gattis, Dieter Ebert

et al.

G3 Genes Genomes Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 21, 2024

Abstract Having alternative infection routes is thought to help parasites circumvent host resistance, provided that these are associated with different resistance loci. This study tests this postulate by examining whether alternate of the parasite Pasteuria ramosa linked distinct loci in its crustacean host, Daphnia magna. We focus on P. isolate P15, which can attach and penetrate through either hindgut or foregut. Using a global panel 174 D. magna genotypes supplemented breeding experiments, we analyzed patterns for each routes. Our findings confirm our hypothesis: magna, attachment determined D locus, while foregut controlled newly identified G locus. established gene model locus indicated Mendelian segregation epistatic interaction at least one other ramosa, C genomic Pool-sequencing data, localized within known Resistance Complex chromosome 4 whereas 7. Two candidate genes belonging Glycosyltransferase family, were identified. sheds new light host–parasite coevolution enhances understanding how evolve strategies.

Language: Английский

Genetic basis of resistance in hosts facing alternative infection strategies by a virulent bacterial pathogen DOI Creative Commons
Eglantine Mathieu‐Bégné, Sabrina Gattis, Dieter Ebert

et al.

G3 Genes Genomes Genetics, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 21, 2024

Abstract Having alternative infection routes is thought to help parasites circumvent host resistance, provided that these are associated with different resistance loci. This study tests this postulate by examining whether alternate of the parasite Pasteuria ramosa linked distinct loci in its crustacean host, Daphnia magna. We focus on P. isolate P15, which can attach and penetrate through either hindgut or foregut. Using a global panel 174 D. magna genotypes supplemented breeding experiments, we analyzed patterns for each routes. Our findings confirm our hypothesis: magna, attachment determined D locus, while foregut controlled newly identified G locus. established gene model locus indicated Mendelian segregation epistatic interaction at least one other ramosa, C genomic Pool-sequencing data, localized within known Resistance Complex chromosome 4 whereas 7. Two candidate genes belonging Glycosyltransferase family, were identified. sheds new light host–parasite coevolution enhances understanding how evolve strategies.

Language: Английский

Citations

0