Inversions Can Accumulate Balanced Sexual Antagonism: Evidence from Simulations and Drosophila Experiments DOI Creative Commons
Christopher S McAllester, John E. Pool

eLife, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 28, 2023

Chromosomal inversion polymorphisms can be common, but the causes of their persistence are often unclear. We propose a model for maintenance polymorphism, which requires that some variants contribute antagonistically to two phenotypes, one has negative frequency-dependent fitness. These conditions yield form disruptive selection, favoring predominant haplotypes segregating alleles favor opposing antagonistic phenotypes. An associated with haplotype reduce fitness load incurred by generating recombinant offspring, reinforcing its linkage and enabling both accumulate more than expected otherwise. develop apply forward simulator examine these dynamics under tradeoff between survival male display. simulations indeed generate inversion-associated sex-specific effects. Antagonism strengthens time, ultimately karyotypes at surprisingly predictable frequencies, striking genotype frequency differences sexes developmental stages. To test whether this may well-studied yet enigmatic in Drosophila melanogaster , we track frequencies laboratory crosses they influence reproductive success or survival. find four tested inversions show significant evidence examined, In(3R)K In(3L)Ok reproduction. In line apparent effects implied those inversions, was also found less costly viability and/or longevity males females, whereas beneficial female Based on work, expect balancing selection pleiotropic traits provide underappreciated contribution natural polymorphism.

Language: Английский

Inversions Can Accumulate Balanced Sexual Antagonism: Evidence from Simulations and Drosophila Experiments DOI Open Access
Christopher S McAllester, John E. Pool

Published: Jan. 23, 2025

Chromosomal inversion polymorphisms can be common, but the causes of their persistence are often unclear. We propose a model for maintenance polymorphism, which requires that some variants contribute antagonistically to two phenotypes, one has negative frequency-dependent fitness. These conditions yield form disruptive selection, favoring predominant haplotypes segregating alleles favor opposing antagonistic phenotypes. An associated with haplotype reduce fitness load incurred by generating recombinant offspring, reinforcing its linkage and enabling both accumulate more than expected otherwise. develop apply forward simulator examine these dynamics under tradeoff between survival male display. simulations indeed generate inversion-associated sex-specific effects. Antagonism strengthens time, ultimately karyotypes at surprisingly predictable frequencies, striking genotype frequency differences sexes developmental stages. To test whether this may well-studied yet enigmatic in Drosophila melanogaster , we track frequencies laboratory crosses they influence reproductive success or survival. find four tested inversions show significant evidence examined, In(3R)K In(3L)Ok reproduction. In line apparent effects implied those inversions, was also found less costly viability and/or longevity males females, whereas beneficial female Based on work, expect balancing selection pleiotropic traits provide underappreciated contribution natural polymorphism.

Language: Английский

Citations

0
Incomplete recombination suppression fuels extensive haplotype diversity in a butterfly colour pattern supergene DOI Creative Commons
Rishi De‐Kayne, I. Gordon, Reinier F. Terblanche

et al.

PLoS Biology, Journal Year: 2025, Volume and Issue: 23(2), P. e3003043 - e3003043

Published: Feb. 28, 2025

Supergenes can evolve when recombination-suppressing mechanisms like inversions promote co-inheritance of alleles at two or more polymorphic loci that affect a complex trait. Theory shows such genetic architectures be favoured under balancing selection local adaptation in the face gene flow, but they also bring costs associated with reduced opportunities for recombination. These may turn offset by rare ‘gene flux’ between inverted and ancestral haplotypes, range possible outcomes. We aimed to shed light on these processes investigating BC supergene, large genomic region comprising multiple rearrangements three distinct wing colour morphs Danaus chrysippus , butterfly known as African monarch, queen plain tiger. Using whole-genome resequencing data from 174 individuals, we first confirm effects pattern: background melanism is SNPs promoter yellow within an subregion while forewing tip pattern most likely copy-number variation separate supergene. then show haplotype diversity supergene surprisingly extensive: there are least six divergent groups experience suppressed recombination respect each other. Despite high divergence groups, identify unexpectedly number natural recombinant haplotypes. Several inferred crossovers occurred adjacent inversion ‘modules’, others inversions. Furthermore, new have arisen through pre-existing ones. Specifically, allele dark colouration has recombined into backgrounds occasions. Overall, our findings paint picture dynamic evolution fuelled incomplete suppression.

Language: Английский

Citations

0
The potential of inversions to accumulate balanced sexual antagonism is supported by simulations and Drosophila experiments DOI Creative Commons
Christopher S McAllester, John E. Pool

eLife, Journal Year: 2025, Volume and Issue: 12

Published: April 16, 2025

Chromosomal inversion polymorphisms can be common, but the causes of their persistence are often unclear. We propose a model for maintenance polymorphism, which requires that some variants contribute antagonistically to two phenotypes, one has negative frequency-dependent fitness. These conditions yield form disruptive selection, favoring predominant haplotypes segregating alleles favor opposing antagonistic phenotypes. An associated with haplotype reduce fitness load incurred by generating recombinant offspring, reinforcing its linkage and enabling both accumulate more than expected otherwise. develop apply forward simulator examine these dynamics under tradeoff between survival male display. simulations indeed generate inversion-associated sex-specific effects. Antagonism strengthens time, ultimately karyotypes at surprisingly predictable frequencies, striking genotype frequency differences sexes developmental stages. To test whether this may well-studied yet enigmatic in Drosophila melanogaster , we track frequencies laboratory crosses they influence reproductive success or survival. find four tested inversions show significant evidence examined, In(3 R)K L)Ok reproduction. In line apparent effects implied those inversions, was also found less costly viability and/or longevity males females, whereas beneficial female Based on work, expect balancing selection pleiotropic traits provide underappreciated contribution natural polymorphism.

Language: Английский

Citations

0
Extensive haplotype diversity in a butterfly colour pattern supergene is fuelled by incomplete recombination suppression DOI Creative Commons
Rishi De‐Kayne, I. Gordon, Reinier F. Terblanche

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: July 26, 2024

Abstract Supergenes can evolve when recombination-suppressing mechanisms like inversions promote co-inheritance of alleles at two or more polymorphic loci that affect a complex trait. Theory shows such genetic architectures be favoured under balancing selection local adaptation in the face gene flow, but they also bring costs associated with reduced opportunities for recombination. These may turn offset by rare ‘gene flux’ between inverted and ancestral haplotypes, range possible outcomes. We aimed to shed light on these processes investigating BC supergene, which underlies three distinct wing colour morphs Danaus chrysippus , butterfly known as African monarch, queen plain tiger. Using whole-genome resequencing data from 174 individuals, we first confirm effects pattern: background coloration is SNPs promoter region yellow within an inversionted part while forewing tip pattern most likely copy-number-variable same supergene. then show haplotype diversity supergene surprisingly extensive: there are least six divergent groups experience suppressed recombination respect each other. Despite high divergence groups, identify unexpectedly large number natural recombinant haplotypes. evidently arose through crossovers adjacent inversion ‘modules’ well double inversions. Furthermore, one established probably pre-existing ones. Moreover, occasions, have led transfer dark colouration onto different background. Overall, our findings paint picture dynamic evolution fuelled incomplete suppression.

Language: Английский

Citations

1
Inversions Can Accumulate Balanced Sexual Antagonism: Evidence from Simulations and Drosophila Experiments DOI Open Access
Christopher S McAllester, John E. Pool

Published: Aug. 27, 2024

Chromosomal inversion polymorphisms can be common, but the causes of their persistence are often unclear. We propose a model for maintenance polymorphism, which requires that some variants contribute antagonistically to two phenotypes, one has negative frequency-dependent fitness. These conditions yield form disruptive selection, favoring predominant haplotypes segregating alleles favor opposing antagonistic phenotypes. An associated with haplotype reduce fitness load incurred by generating recombinant offspring, reinforcing its linkage and enabling both accumulate more than expected otherwise. develop apply forward simulator examine these dynamics under tradeoff between survival male display. simulations indeed generate inversion-associated sex-specific effects. Antagonism strengthens time, ultimately karyotypes at surprisingly predictable frequencies, striking genotype frequency differences sexes developmental stages. To test whether this may well-studied yet enigmatic in Drosophila melanogaster , we track frequencies laboratory crosses they influence reproductive success or survival. find four tested inversions show significant evidence examined, In(3R)K In(3L)Ok reproduction. In line apparent effects implied those inversions, was also found less costly viability and/or longevity males females, whereas beneficial female Based on work, expect balancing selection pleiotropic traits provide underappreciated contribution natural polymorphism.

Language: Английский

Citations

0
Inversions Can Accumulate Balanced Sexual Antagonism: Evidence from Simulations and Drosophila Experiments DOI Creative Commons
Christopher S McAllester, John E. Pool

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 3, 2023

Abstract Chromosomal inversion polymorphisms can be common, but the causes of their persistence are often unclear. We propose a model for maintenance polymorphism, which requires that some variants contribute antagonistically to two phenotypes, one has negative frequency-dependent fitness. These conditions yield form disruptive selection, favoring predominant haplotypes segregating alleles favor opposing antagonistic phenotypes. An associated with haplotype reduce fitness load incurred by generating recombinant offspring, reinforcing its linkage and enabling both accumulate more than expected otherwise. develop apply forward simulator examine these dynamics under tradeoff between survival male display. simulations indeed generate inversion-associated sex-specific effects. Antagonism strengthens time, ultimately karyotypes at surprisingly predictable frequencies, striking genotype frequency differences sexes developmental stages. To test whether this may well-studied yet enigmatic in Drosophila melanogaster , we track frequencies laboratory crosses they influence reproductive success or survival. find four tested inversions show significant evidence examined, In(3R)K In(3L)Ok reproduction. In line apparent effects implied those inversions, was also found less costly viability and/or longevity males females, whereas beneficial female Based on work, expect balancing selection pleiotropic traits provide underappreciated contribution natural polymorphism.

Language: Английский

Citations

0
Inversions Can Accumulate Balanced Sexual Antagonism: Evidence from Simulations and Drosophila Experiments DOI Creative Commons
Christopher S McAllester, John E. Pool

eLife, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 28, 2023

Chromosomal inversion polymorphisms can be common, but the causes of their persistence are often unclear. We propose a model for maintenance polymorphism, which requires that some variants contribute antagonistically to two phenotypes, one has negative frequency-dependent fitness. These conditions yield form disruptive selection, favoring predominant haplotypes segregating alleles favor opposing antagonistic phenotypes. An associated with haplotype reduce fitness load incurred by generating recombinant offspring, reinforcing its linkage and enabling both accumulate more than expected otherwise. develop apply forward simulator examine these dynamics under tradeoff between survival male display. simulations indeed generate inversion-associated sex-specific effects. Antagonism strengthens time, ultimately karyotypes at surprisingly predictable frequencies, striking genotype frequency differences sexes developmental stages. To test whether this may well-studied yet enigmatic in Drosophila melanogaster , we track frequencies laboratory crosses they influence reproductive success or survival. find four tested inversions show significant evidence examined, In(3R)K In(3L)Ok reproduction. In line apparent effects implied those inversions, was also found less costly viability and/or longevity males females, whereas beneficial female Based on work, expect balancing selection pleiotropic traits provide underappreciated contribution natural polymorphism.

Language: Английский

Citations

0