Pervasive tissue-, genetic background-, and allele-specific gene expression effects in Drosophila melanogaster DOI Creative Commons
Amanda Glaser‐Schmitt, Marion Lemoine, Martin Kaltenpoth

et al.

PLoS Genetics, Journal Year: 2024, Volume and Issue: 20(8), P. e1011257 - e1011257

Published: Aug. 23, 2024

The pervasiveness of gene expression variation and its contribution to phenotypic evolution is well known. This context dependent, with differences in regulatory architecture often associated intrinsic environmental factors, modulated by elements that can act cis (linked) or trans (unlinked) relative the genes they affect. So far, little known about how this genetic affects among closely related tissues during population divergence. To address question, we analyzed midgut, hindgut, Malpighian tubule as microbiome composition two gut four Drosophila melanogaster strains their F1 hybrids from divergent populations: one derived, European range ancestral, African range. In both transcriptome data, detected extensive tissue- background-specific effects, including effects background on overall tissue specificity. Tissue-specific were typically stronger than although not more similar each other tubules. An examination allele specific revealed that, while tissue-specific expressed differentially between populations conserved expression, effects. Despite there being highly variable architecture, observation was robust across backgrounds, suggesting be spatially fine-tuned better divergence yielding new insights into evolution.

Language: Английский

Pervasive tissue-, genetic background-, and allele-specific gene expression effects inDrosophila melanogaster DOI Creative Commons
Amanda Glaser‐Schmitt, Marion Lemoine, Martin Kaltenpoth

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 20, 2024

Abstract The pervasiveness of gene expression variation and its contribution to phenotypic evolution is well known. This context dependent, with differences in regulatory architecture often associated intrinsic environmental factors, modulated by elements that can act cis (linked) or trans (unlinked) relative the genes they affect. So far, little known about how this genetic affects among closely related tissues during population divergence. To address question, we analyzed midgut, hindgut, Malpighian tubule as microbiome composition two gut four Drosophila melanogaster strains their F1 hybrids from divergent populations: one derived, European range ancestral, African range. In both transcriptome data, detected extensive tissue- background-specific effects, including effects background on overall tissue specificity. Tissue-specific were typically stronger than although not more similar each other tubules. An examination allele specific revealed that, while tissue-specific expressed differentially between populations conserved expression, effects. Despite there being highly variable architecture, observation was robust across backgrounds, suggesting be spatially fine-tuned better divergence yielding new insights into evolution. Author Summary Genetic variants regulating affect are thought important adaptation because temporally fine-tune expression. study, used fruit fly compare inbred parental offspring order characterize basis regulation inheritance. We examined three (midgut, tubule) backgrounds stemming Europe ancestral Africa. Additionally, characterized bacterial community tissues. composition, Genes those These results suggest (or than) diverge another. Our study yields novel insight

Language: Английский

Citations

0
Pervasive tissue-, genetic background-, and allele-specific gene expression effects in Drosophila melanogaster DOI Creative Commons
Amanda Glaser‐Schmitt, Marion Lemoine, Martin Kaltenpoth

et al.

PLoS Genetics, Journal Year: 2024, Volume and Issue: 20(8), P. e1011257 - e1011257

Published: Aug. 23, 2024

The pervasiveness of gene expression variation and its contribution to phenotypic evolution is well known. This context dependent, with differences in regulatory architecture often associated intrinsic environmental factors, modulated by elements that can act cis (linked) or trans (unlinked) relative the genes they affect. So far, little known about how this genetic affects among closely related tissues during population divergence. To address question, we analyzed midgut, hindgut, Malpighian tubule as microbiome composition two gut four Drosophila melanogaster strains their F1 hybrids from divergent populations: one derived, European range ancestral, African range. In both transcriptome data, detected extensive tissue- background-specific effects, including effects background on overall tissue specificity. Tissue-specific were typically stronger than although not more similar each other tubules. An examination allele specific revealed that, while tissue-specific expressed differentially between populations conserved expression, effects. Despite there being highly variable architecture, observation was robust across backgrounds, suggesting be spatially fine-tuned better divergence yielding new insights into evolution.

Language: Английский

Citations

0