Behavioral adaptations of Caenorhabditis elegans against pathogenic threats DOI Creative Commons
Xin Zhao, Xinyu Li, Jiayi Gao

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19294 - e19294

Published: April 14, 2025

This review examines the behavioral adaptation mechanisms of Caenorhabditis elegans in response to pathogenic bacterial threats, emphasizing their ecological significance. It systematically explores how such as avoidance behavior, transgenerational learning, and forgetting enable C. optimize its survival reproductive strategies within dynamic microbial environments. detects harmful signals through chemosensation initiates behaviors. Simultaneously, it manages environmental energy allocation memory forgetting, allowing cope with selective pressures from fluctuations. In contrast, bacteria Pseudomonas aeruginosa Salmonella influence behavior toxin release biofilm formation, highlighting complex co-evolutionary dynamics between hosts pathogens. Additionally, these pathogens employ “Trojan Horse-like” “Worm Star” kill , further complicating host-pathogen interactions. These processes are driven by adaptations, biochemical signaling, evolutionary pressures, which emphasize niche ecosystems. serves a valuable model for studying study provides crucial theoretical insights into adaptive evolution ecosystem dynamics, offering guidance development biocontrol effective management

Language: Английский

Impact of mercury on fitness and interactions of soil nematodes Rhabditis sp. and Cephalobus sp. in microcosms DOI
Julius Kevin Cura, Juan Gabriel Martínez

International Journal of Environmental Science and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Language: Английский

Citations

0
Berberine Extends Lifespan in C. elegans Through Multi-Target Synergistic Antioxidant Effects DOI Creative Commons

Yingshuo Bei,

Ting Wang, Shuwen Guan

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 450 - 450

Published: April 9, 2025

Aging is a process of gradual functional decline in complex physiological systems and closely related to the occurrence various diseases. Berberine, bioactive alkaloid derived from Coptis chinensis (Huanglian), has emerged as promising candidate for anti-aging interventions. This study comprehensively investigated lifespan-extending effects molecular mechanisms berberine C. elegans through integrated approaches including lifespan assays, locomotor activity analysis, oxidative stress challenges, transcriptomic profiling. Furthermore, genetic models mutant transgenic worms were employed delineate their interactions with insulin/IGF-1 signaling (IIS) pathway. Our results demonstrate that extended mean wild-type by 27%. By activating transcription factors such DAF-16/FOXO, HSF-1, SKN-1/NRF2, upregulated antioxidant enzyme expression, reduced lipofuscin accumulation, improved resistance. Transcriptomic analysis revealed significant changes lipid metabolism-related genes, particularly pathways involving fatty acid synthesis, degradation, sphingolipid metabolism. These findings establish exerts multi-target coordinated activation stress-responsive metabolic optimization, providing mechanistic insights developing natural product-based geroprotective strategies.

Language: Английский

Citations

0
Behavioral adaptations of Caenorhabditis elegans against pathogenic threats DOI Creative Commons
Xin Zhao, Xinyu Li, Jiayi Gao

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19294 - e19294

Published: April 14, 2025

This review examines the behavioral adaptation mechanisms of Caenorhabditis elegans in response to pathogenic bacterial threats, emphasizing their ecological significance. It systematically explores how such as avoidance behavior, transgenerational learning, and forgetting enable C. optimize its survival reproductive strategies within dynamic microbial environments. detects harmful signals through chemosensation initiates behaviors. Simultaneously, it manages environmental energy allocation memory forgetting, allowing cope with selective pressures from fluctuations. In contrast, bacteria Pseudomonas aeruginosa Salmonella influence behavior toxin release biofilm formation, highlighting complex co-evolutionary dynamics between hosts pathogens. Additionally, these pathogens employ “Trojan Horse-like” “Worm Star” kill , further complicating host-pathogen interactions. These processes are driven by adaptations, biochemical signaling, evolutionary pressures, which emphasize niche ecosystems. serves a valuable model for studying study provides crucial theoretical insights into adaptive evolution ecosystem dynamics, offering guidance development biocontrol effective management

Language: Английский

Citations

0