NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse populations DOI Creative Commons
Monica Driscoll, Christine A. Sedore, Brian Onken

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

A core facet of the National Institute on Aging's mission is to identify pharmacological interventions that can promote human healthy aging and long life. As part comprehensive effort toward goal, NIA Division Biology Aging established Caenorhabditis Intervention Testing Program (CITP) in 2013. The C. elegans model (with an ~ 21 day lifespan) has led field dissection longevity genetics offers features allow for relatively rapid testing potential elaboration biological mechanisms engaged by candidate geroprotectants. CITP builds this foundation utilizing a genetically diverse set intervention test strains so "subjects" represent genetic diversity akin between mouse humans. Another distinctive aspect dedicated focus reproducibility outcomes as labs at three independent sites confirm positive outcomes. overall goal robust reproducible pro-longevity affecting cohorts genus. strong Data Collection Center supports data collection dissemination. Pharmacological tested be nominated general public, directed in-house screens, or supported published scientific literature. December 2024, > 75 compounds conducted 725,000 animal assays over 891 trials. We identified 12 confer ≥ 20% increase median lifespan reproducibly robustly extend across multiple labs. Five these have impact reported literature (most are not yet mouse). celebration 50th Anniversary NIA, we review development history accomplishments program, comment translation promise advancing understanding fundamental biology includes intervention/health interface.

Language: Английский

Hallmarks of aging: middle-aging hypovascularity, tissue perfusion and nitric oxide perspective on healthspan DOI Creative Commons

Teow J. Phua

Frontiers in Aging, Journal Year: 2025, Volume and Issue: 5

Published: Jan. 7, 2025

Aging is a complex process marked by various changes at both cellular and systemic levels, impacting the functioning lifespan of organisms. Over time, researchers have pinpointed several significant hallmarks aging that lead to gradual deterioration tissue function, regulation, homeostasis associated with in humans. Despite this, intricate interactions cumulative effects these are still mostly uncharted territory. Understanding this web major challenge Geroscience, yet it crucial for developing effective strategies promote healthy aging, reduce medical costs, ensure sustainability health systems. Gaining insights area essential creating interventions can slow process, enhance healthspan, decrease likelihood age-related diseases. The integration knowledge from fields concerning middle-aging nitric oxide (NO)-mediated hypovascularity hypoxia hemodynamic hypothesis points systems-based approach biological aging. Key evidence suggests connection between endocrine system (specifically sex hormones), endogenous NO deficiency, vascular system, which serves as network microvascular structures perfusion functions level. These processes also involve oxidative stress inflammation triggered hypoxia.

Language: Английский

Citations

0
NIA Caenorhabditis Intervention Testing Program: identification of robust and reproducible pharmacological interventions that promote longevity across experimentally accessible, genetically diverse populations DOI Creative Commons
Monica Driscoll, Christine A. Sedore, Brian Onken

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

A core facet of the National Institute on Aging's mission is to identify pharmacological interventions that can promote human healthy aging and long life. As part comprehensive effort toward goal, NIA Division Biology Aging established Caenorhabditis Intervention Testing Program (CITP) in 2013. The C. elegans model (with an ~ 21 day lifespan) has led field dissection longevity genetics offers features allow for relatively rapid testing potential elaboration biological mechanisms engaged by candidate geroprotectants. CITP builds this foundation utilizing a genetically diverse set intervention test strains so "subjects" represent genetic diversity akin between mouse humans. Another distinctive aspect dedicated focus reproducibility outcomes as labs at three independent sites confirm positive outcomes. overall goal robust reproducible pro-longevity affecting cohorts genus. strong Data Collection Center supports data collection dissemination. Pharmacological tested be nominated general public, directed in-house screens, or supported published scientific literature. December 2024, > 75 compounds conducted 725,000 animal assays over 891 trials. We identified 12 confer ≥ 20% increase median lifespan reproducibly robustly extend across multiple labs. Five these have impact reported literature (most are not yet mouse). celebration 50th Anniversary NIA, we review development history accomplishments program, comment translation promise advancing understanding fundamental biology includes intervention/health interface.

Language: Английский

Citations

0