Glycosaminoglycans, Instructive Biomolecules That Regulate Cellular Activity and Synaptic Neuronal Control of Specific Tissue Functional Properties
International Journal of Molecular Sciences,
Journal Year:
2025,
Volume and Issue:
26(6), P. 2554 - 2554
Published: March 12, 2025
Glycosaminoglycans
(GAGs)
are
a
diverse
family
of
ancient
biomolecules
that
evolved
over
millennia
as
key
components
in
the
glycocalyx
surrounds
all
cells.
GAGs
have
molecular
recognition
and
cell
instructive
properties
when
attached
to
surface
extracellular
matrix
(ECM)
proteoglycans
(PGs),
which
act
effector
molecules
regulate
cellular
behavior.
The
perception
mechanical
cues
arise
from
perturbations
ECM
microenvironment
allow
undertake
appropriate
biosynthetic
responses
maintain
composition
tissue
function.
PGs
substituted
with
provide
structural
support
weight-bearing
tissues
an
ability
withstand
shear
forces
some
contexts.
This
review
outlines
complexity
functional
they
convey
PGs.
important
roles
cartilaginous
fibrocartilages
subject
tension
high
also
vascular
neural
tissues.
Specific
synaptic
stabilization
specificity
plasticity
regulation
neurophysiological
CNS/PNS
control
A
better
understanding
GAG
instructional
behavior
may
be
insightful
for
development
GAG-based
biotherapeutics
designed
treat
dysfunction
disease
processes
novel
repair
strategies
following
trauma.
significant
level
sophistication
many
contexts,
needs
fully
deciphered
order
achieve
useful
therapeutic
product.
offers
exciting
opportunities
modern
glycomics
arena.
Language: Английский
Lumican, a Multifunctional Cell Instructive Biomarker Proteoglycan Has Novel Roles as a Marker of the Hypercoagulative State of Long Covid Disease
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(5), P. 2825 - 2825
Published: Feb. 29, 2024
This
study
has
reviewed
the
many
roles
of
lumican
as
a
biomarker
tissue
pathology
in
health
and
disease.
Lumican
is
structure
regulatory
proteoglycan
collagen-rich
tissues,
with
cell
instructive
properties
through
interactions
number
surface
receptors
repair,
thereby
regulating
proliferation,
differentiation,
inflammation
innate
humoral
immune
systems
to
combat
infection.
The
exponential
increase
publications
last
decade
dealing
testify
its
role
pleiotropic
protein.
Recent
findings
show
novel
hypercoagulative
state
that
occurs
SARS
CoV-2
infections;
thus,
it
may
also
prove
useful
delineation
complex
changes
characterize
COVID-19
be
prognostic
diagnostic
long
COVID
disease
sequelae.
Language: Английский