Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 31, 2024
Some individuals show intact cognition despite the presence of neuropathological hallmarks Alzheimer's disease (AD). The plasticity parvalbumin (PV)-containing interneurons might contribute to resilience. Perineuronal nets (PNNs), that is, extracellular matrix structures around neurons, modulate PV neuron function. We hypothesize PNNs play a role in resilience AD.
Language: Английский
Cells, Journal Year: 2025, Volume and Issue: 14(5), P. 321 - 321
Published: Feb. 20, 2025
Perineuronal nets (PNNs) are specialized extracellular matrix structures that predominantly surround inhibitory neurons in the central nervous system (CNS). They have been identified as crucial regulators of synaptic plasticity and neuronal excitability. This literature review aims to summarize current state knowledge about PNNs, their molecular composition structure, well functional roles involvement neurological diseases. Furthermore, future directions PNN research proposed, therapeutic potential targeting PNNs develop novel treatment options for various disorders is explored. emphasizes importance CNS physiology pathology underscores need further this area.
Language: Английский
Citations
0
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 25, 2025
Sharp wave ripple (SWR) events, present in diverse species, spontaneously occur the hippocampus during quiescent restfulness and slow-wave sleep. SWRs comprise a negative deflection, sharp (SW) event with an often-superimposed (R) are neural correlates of memory consolidation recall. The Anterodorsolateral lobe (ADL) (zebrafish hippocampal homologue) exhibits SW SWR since SWs initiate SWRs, their abundance typically shows same directionality. In previous work, we observed matrix metalloproteinase-9 (MMP-9)-dependent effects on depression-relevant behaviors, perineuronal net (PNN) levels, adult rodent hippocampus. Here, investigate MMP-2/9-dependent biochemical, behavioral, neurophysiological endpoints juvenile zebrafish at transition from late period to early adulthood. With MMP-2/9 inhibition, showed reduced amplitude together increased fear retention sociability. Juvenile also percentage longer-duration events. Except for reduction amplitude, these changes were not These accompanied by levels chondroitin sulfate (CS) proteoglycan 4- O -sulfation, which modulates PNNs excitatory-to-inhibitory (E/I) balance. Discontinuation inhibition normalized deficits ADL Together, findings show that significantly influences E/I balance learning highly plastic zebrafish. Findings have relevance emerging appreciation PNN may contribute altered neuronal oscillations mood or cognition.
Language: Английский
Citations
0
Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown
Published: May 2, 2025
Language: Английский
Citations
0
Biomolecules, Journal Year: 2024, Volume and Issue: 14(9), P. 1087 - 1087
Published: Aug. 30, 2024
The extracellular matrix plays a key role in synapse formation and the modulation of synaptic function central nervous system. Recent investigations have revealed that microglia, resident immune cells brain, are involved remodeling under both physiological pathological conditions. Moreover, dysregulation innate responses has been documented stress-related psychopathologies as well relation to early-life stress. However, dynamics microglial regulation ECM how it can be impacted by adversity understudied. This brief review provides an overview recent literature on this topic, drawing from animal model human post mortem studies. Direct indirect mechanisms through which microglia may regulate matrix-including perineuronal nets-are presented discussed light interactions with other cell types.
Language: Английский
Citations
3
Journal of the American Society for Mass Spectrometry, Journal Year: 2025, Volume and Issue: unknown
Published: March 3, 2025
Chondroitin sulfate (CS) is a type of glycosaminoglycan (GAG) that abundant in cartilage and perineural networks (PNNs). Changes the CS signature PNNs have been implicated several neurological diseases. Most CS-GAGs contain labile groups, which can be lost during ionization events deposit large amounts internal energy. Infrared matrix-assisted laser desorption electrospray (IR-MALDESI) soft technique used for mass spectrometry imaging. In this work, we determine spatial distribution CS-GAG disaccharides within rodent brain using IR-MALDESI MSI. Non-, mono-, disulfated were detected with various adducts. All colocalized to PNNs, are most cortex hippocampus regions brain. This first MSI study spatially resolve brain, paving way measure GAGs
Language: Английский
Citations
0
Somatosensory & Motor Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16
Published: March 11, 2025
Perineuronal nets (PNNs) are specialised extracellular matrix structures of the central nervous system that predominantly surround inhibitory interneurons. The development PNNs is activity dependent and relies on sensory input to mature an adult expression pattern, coinciding with crysallization synaptic circuitry following closure developmental critical period. Our results a neocortical characterisation demonstrate density in neocortex Long Evans rat was consistent across animals but varied as function cortical region. Utilising non-biased random effect model, it shown retrosplenial granular cortex had highest PNN intermediate endopiriform lowest. Given importance mystacial vibrissae behaviour rodents, we further analysed laminar distribution within primary somatosensory (S1). revealed layer IV, 'barrel' region, contained PNNs. Within S1, all subregions. S1 significantly higher compared motor (M1) cortex, levels did not show lateralisation either M1 or S1. Independent location, observed novel class relatively large, brightly stained neurons ensheathed by PNNs, which were present exclusively along VI-white matter border. A better understanding their can assist our how manipulation affect neurological conditions such schizophrenia, epilepsy, stroke, injuries, degenerative processes.
Language: Английский
Citations
0
Neurobiology of Stress, Journal Year: 2024, Volume and Issue: 33, P. 100692 - 100692
Published: Nov. 1, 2024
Perineuronal nets (PNNs) are a special form of central nervous system extracellular matrix enriched in hyaluronan, chondroitin sulfate proteoglycans, tenascins, and link proteins that regulate synaptic plasticity. Most PNNs the brain surround parvalbumin-expressing inhibitory interneurons, which tightly excitatory/inhibitory balance activity associated with optimal cognitive functioning. Alterations have been observed neurological diseases psychiatric disorders, suggesting they may be key contributors to neuropathological progression behavioral changes these diseases. Alcohol use disorder (AUD), major depressive (MDD), chronic pain highly comorbid conditions, animal models as well postmortem tissue from individuals diagnosed AUD MDD. This review focuses on literature describing stress-, alcohol-, pain-induced adaptations PNNs, potential cellular altered role behaviors related disorders. Medicines can restore non-pathological state novel therapeutic approach treating pain, AUD,
Language: Английский
Citations
0
Alzheimer s & Dementia, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 31, 2024
Some individuals show intact cognition despite the presence of neuropathological hallmarks Alzheimer's disease (AD). The plasticity parvalbumin (PV)-containing interneurons might contribute to resilience. Perineuronal nets (PNNs), that is, extracellular matrix structures around neurons, modulate PV neuron function. We hypothesize PNNs play a role in resilience AD.
Language: Английский
Citations
0