The genetics of mammalian circadian order and disorder: implications for physiology and disease

Nature Reviews Genetics, Journal Year: 2008, Volume and Issue: 9(10), P. 764 - 775

Published: Sept. 18, 2008

Language: Английский

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Molecular architecture of the mammalian circadian clock

Trends in Cell Biology, Journal Year: 2013, Volume and Issue: 24(2), P. 90 - 99

Published: Aug. 1, 2013

Language: Английский

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Circadian Typology: A Comprehensive Review

Chronobiology International, Journal Year: 2012, Volume and Issue: 29(9), P. 1153 - 1175

Published: Sept. 24, 2012

The interest in the systematic study of circadian typology (CT) is relatively recent and has developed rapidly two last decades.All existing data suggest that this individual difference affects our biological psychological functioning, not only health, but also disease.In present study, we review current literature concerning psychometric properties validity CT measures as well individual, environmental genetic factors influence CT.We a brief overview markers are used to define differences between groups (sleep-wake cycle, body temperature, cortisol, melatonin), assess implications for adjustment shift work jet-lag.We terms cognitive abilities, personality traits incidence psychiatric disorders.When necessary, have emphasized methodological limitations exist today suggested some future avenues order overcome these.This new field professionals many different areas (research, labor, academic, clinical) provides state art discussion allow integrate chronobiological aspects human behavior into their daily practice.

Language: Английский

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JTK_CYCLE: An Efficient Nonparametric Algorithm for Detecting Rhythmic Components in Genome-Scale Data Sets

Journal of Biological Rhythms, Journal Year: 2010, Volume and Issue: 25(5), P. 372 - 380

Published: Sept. 28, 2010

Circadian rhythms are oscillations of physiology, behavior, and metabolism that have period lengths near 24 hours. In several model organisms humans, circadian clock genes been characterized found to be transcription factors. Because this, researchers used microarrays characterize global regulation gene expression algorithmic approaches detect cycling. This article presents a new algorithm, JTK_CYCLE, designed efficiently identify cycling variables in large data sets. Compared with COSOPT the Fisher’s G test, two commonly methods for detecting transcripts, JTK_CYCLE distinguishes between rhythmic nonrhythmic transcripts more reliably efficiently. JTK_CYCLE’s increased resistance outliers results considerably greater sensitivity specificity. Moreover, accurately measures period, phase, amplitude facilitating downstream analyses. Finally, is orders magnitude faster than COSOPT, making it ideal large-scale was analyze legacy sets including NIH3T3 cells, which comparatively low oscillations. improved power led identification novel cluster RNA-interacting whose abundance under clear regulation. These suggest an tool identifying characterizing genome-scale

Language: Английский

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Physiological significance of a peripheral tissue circadian clock

Proceedings of the National Academy of Sciences, Journal Year: 2008, Volume and Issue: 105(39), P. 15172 - 15177

Published: Sept. 9, 2008

Mammals have circadian clocks in peripheral tissues, but there is no direct evidence of their physiological importance. Unlike the suprachiasmatic nucleus clock that set by light and drives rest-activity fasting-feeding cycles, are daily feeding, suggesting at least some contribute metabolic regulation. The liver plays a well known role glucose homeostasis, we report here mice with liver-specific deletion Bmal1, an essential component, exhibited hypoglycemia restricted to fasting phase feeding cycle, exaggerated clearance, loss rhythmic expression hepatic regulatory genes. We conclude important for buffering circulating time-of-day-dependent manner. Our findings suggest contributes homeostasis driving rhythm export counterbalances cycle ingestion resulting from cycle.

Language: Английский

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Physiology of Circadian Entrainment

Physiological Reviews, Journal Year: 2010, Volume and Issue: 90(3), P. 1063 - 1102

Published: July 1, 2010

Mammalian circadian rhythms are controlled by endogenous biological oscillators, including a master clock located in the hypothalamic suprachiasmatic nuclei (SCN). Since period of this oscillation is ∼24 h, to keep synchrony with environment, need be entrained daily means Zeitgeber (“time giver”) signals, such as light-dark cycle. Recent advances neurophysiology and molecular biology rhythmicity allow better understanding synchronization. In review we cover several aspects mechanisms for photic entrainment mammalian rhythms, retinal sensitivity light novel photopigments well variations retina that contribute regulation physiology. Downstream from retina, examine retinohypothalamic communication through neurotransmitter (glutamate, aspartate, pituitary adenylate cyclase-activating polypeptide) interaction SCN receptors resulting signal transduction pathways neurons, putative neuron-glia interactions. Finally, describe analyze gene expression its importance mechanisms, disorders or diseases related deficits, experimental clinical treatments.

Language: Английский

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Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease

Nature reviews. Neuroscience, Journal Year: 2010, Volume and Issue: 11(8), P. 589 - 599

Published: July 14, 2010

Language: Английский

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Mania-like behavior induced by disruption of CLOCK

Proceedings of the National Academy of Sciences, Journal Year: 2007, Volume and Issue: 104(15), P. 6406 - 6411

Published: March 23, 2007

Circadian rhythms and the genes that make up molecular clock have long been implicated in bipolar disorder. Genetic evidence patients suggests central transcriptional activator of rhythms, CLOCK, may be particularly important. However, exact role this gene development disorder remains unclear. Here we show mice carrying a mutation Clock display an overall behavioral profile is strikingly similar to human mania, including hyperactivity, decreased sleep, lowered depression-like behavior, lower anxiety, increase reward value for cocaine, sucrose, medial forebrain bundle stimulation. Chronic administration mood stabilizer lithium returns many these responses wild-type levels. In addition, mutant dopaminergic activity ventral tegmental area, their abnormalities are rescued by expressing functional CLOCK protein via viral-mediated transfer specifically area. These findings establish as previously unrecognized model mania reveal important system regulating behavior mood.

Language: Английский

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The Cryptochromes: Blue Light Photoreceptors in Plants and Animals

Annual Review of Plant Biology, Journal Year: 2011, Volume and Issue: 62(1), P. 335 - 364

Published: March 3, 2011

Cryptochromes are flavoprotein photoreceptors first identified in Arabidopsis thaliana, where they play key roles growth and development. Subsequently prokaryotes, archaea, many eukaryotes, cryptochromes function the animal circadian clock proposed as magnetoreceptors migratory birds. closely structurally related to photolyases, evolutionarily ancient flavoproteins that catalyze light-dependent DNA repair. Here, we review structural, photochemical, molecular properties of cry-DASH, plant, relation biological signaling mechanisms uncover common features may contribute better understanding diverse systems including man.

Language: Английский

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Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

Nature, Journal Year: 2012, Volume and Issue: 485(7396), P. 62 - 68

Published: March 29, 2012

Language: Английский

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